Not exact matches
Furthermore, the team found that ONA inhibited the pro-tumor functions of myeloid derived suppressor cells (MDSC), which are closely associated with the suppression of the anti-tumor immune response of host lymphocytes,
by using
preclinical sarcoma
model.
With this new understanding of how Del - 1 can inhibit periodontal bone loss — both
by reducing inflammation and
by restraining the activity of osteoclasts that resorb bone tissue — the researchers tested it, in a
preclinical model of periodontitis observing that Del - 1 significantly reduced inflammation and tissue damage and that there was significantly less bone loss.
Combining their strategy with an existing immunotherapy treatment that works
by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival in
preclinical models for melanoma.
In a study of
preclinical models of colorectal cancer, the researchers identified an underlying mechanism for the activation of p53
by FL118.
Published this week in the journal Proceedings of the National Academy of Sciences, the scientists found that inhibiting activin A, activin B and myostatin resulted in skeletal muscle mass increase
by as much as 150 per cent in
preclinical models.
The article, «Retrobulbar Inflammation, Adipogenesis and Acute Orbital Congestion in a
Preclinical Female Mouse
Model of Graves» Orbitopathy Induced
by Thyrotropin Receptor Plasmid - in Vivo Electroporation,» will be published in the September issue of Endocrinology.
A major asset of the OMC platform is the tight integration of
preclinical scientists with physicians, who work side
by side to comparatively assess pathogenic, diagnostic and therapeutic issues raised in patients with the mouse
model counterpart.
NeuroPhage has accumulated extensive
preclinical data on this candidate, demonstrating its efficacy across disease
models of Alzheimer's and Parkinson's disease, tauopathies and other related diseases characterized
by aggregation of amyloid beta, tau, and alpha - synuclein proteins.
A humanized bone
model for
preclinical monitoring of prostate cancer lesions
by intravital multiphoton microscopy.
Having a strong R&D department with great experience and expertise in drug development, animal
model and assay development and
preclinical efficacy evaluation, the contribution of Biomedcode has been greatly valued
by our partners, as documented
by our participation in several collaborative research projects.
Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer), with the aim to collaborate in a structured way with French oncology groups, research teams as well as pharmaceutical industry,
by providing
preclinical models and guidance on standard operating procedures for ancillary or future studies in identified population at risk.
M1: Passive transfer studies in
preclinical model performed; Report on protection
by passive therapy with human immune IgG
«Nutrient scavenging
by autophagy is a process that tumors hijack to meet their energetic requirements and to provide the necessary cellular building blocks for growth in a stressed tumor micro-environment» said White, «
Preclinical models have demonstrated a critical role for autophagy in multiple cancer types.»
The scientific focus of our group is at the crossroads of Immunology, Inflammation, Vascular Medicine and Metabolism; we try to merge Basic Science and Translational Medicine
by engaging
preclinical translational animal
models.
and affinity of antibody ACI - 5400 were characterized
by a panel of methods: (i) measuring the selectivity for a specific phospho - Tau epitope known to be associated with tauopathy, (ii) performing a combination of peptide and protein binding assays, (iii) staining of brain sections from mouse
preclinical tauopathy
models and from human subjects representing six different tauopathies, and (iv) evaluating the selective binding to pathological epitopes on extracts from tauopathy brains in non-denaturing sandwich assays.
Promising compounds are being generated using established high throughput screening
by medicinal chemistry and are being tested in
preclinical animal
models.
The Bancroft laboratory was funded
by TBVAC2020 to provide
preclinical animal
models to evaluate new TB vaccine candidates.
This is achieved
by testing vaccine candidates in
preclinical models.