It is currently being evaluated for safety and efficacy in
preclinical models with a Phase I trial expected to begin in 2019.
Dr. Norman Karin, a biologist at PNNL, has identified a lipid growth factor called lysophosphatidic acid (LPA) that promotes bone healing in
preclinical models with no apparent toxicity.
Not exact matches
In
preclinical studies using cell
models that mimicked liver cells of patients
with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.
Furthermore, the team found that ONA inhibited the pro-tumor functions of myeloid derived suppressor cells (MDSC), which are closely associated
with the suppression of the anti-tumor immune response of host lymphocytes, by using
preclinical sarcoma
model.
In multiple
preclinical models, OMP - 54F28 (FZD8 - Fc) has shown its effectiveness in reducing CSC populations, leading to associated anti-tumor activity, either as a single agent or when combined
with chemotherapy.
Currently, Deng's laboratory is conducting additional
preclinical studies using the human - derived stem cells from Down syndrome patients and mouse
models to determine whether cellular and behavioral abnormalities can be improved
with minocycline therapy and other candidate drugs.
Solving these problems in
preclinical models is much more cost effective, but requires a multidisciplinary team that includes formulation experts, polymer scientists, and biologists who can interface
with diverse scientists who don't normally talk to one another.
With this new understanding of how Del - 1 can inhibit periodontal bone loss — both by reducing inflammation and by restraining the activity of osteoclasts that resorb bone tissue — the researchers tested it, in a
preclinical model of periodontitis observing that Del - 1 significantly reduced inflammation and tissue damage and that there was significantly less bone loss.
Combining their strategy
with an existing immunotherapy treatment that works by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival in
preclinical models for melanoma.
The other study — Combination therapy
with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in
preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.
«The
model for
preclinical studies to predict
with great accuracy which drugs would work in the clinic was developed a decade ago,» says Dr. Chesi.
Using all the existing data that was available, Andrechek, along
with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different
preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.
Researchers suggested that other classes of inhibitors be tested in combination
with ERK5 inhibitors in human colorectal cancer cells in
preclinical mouse
models before any patient trial can begin.
Currently, Doody is testing in
preclinical models whether combining this agent
with other, known rheumatoid arthritis treatments results in more efficacious therapies.
According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and
with low cell toxicity on in vitro tests - and broaden
preclinical studies
with laboratory animal
models.
«Stem cell - based therapy for targeting skin - to - brain cancer: Stem cells loaded
with oncolytic viruses show promising results in
preclinical models for targeting skin cancer metastases in the brain.»
Our scientists engage
with you in the design and execution of your
preclinical drug development program using our AAALAC approved animal facilities, proprietary animal
models, and extensive capabilities.
She has identified novel immune - modulating activities associated
with targeted cancer drugs in
preclinical models, and developed synergistic immunotherapy combinations.
A major asset of the OMC platform is the tight integration of
preclinical scientists
with physicians, who work side by side to comparatively assess pathogenic, diagnostic and therapeutic issues raised in patients
with the mouse
model counterpart.
W. Bogers: PhD in immunology and 20 years of experience
with NHP
models for the
preclinical evaluation of HIV vaccine candidates as well as testing antivirals.
Other humanized mice have no spontaneous phenotype and can be combined
with either genetic spontaneous or inducible
models of chronic inflammatory diseases yielding
preclinical efficacy evaluation platforms for Rheumatoid Arthritis, Intestinal Inflammation, Psoriasis and Multiple Sclerosis.
iTeos is now developing EOS200271 which is a synthetic, small molecule inhibitor of indoleamine 2,3 - dioxygenase (IDO1), which has demonstrated the same anti-tumour activity in multiple
preclinical tumour
models in combination
with immune checkpoint inhibitors as competitors, but also has demonstrated superior brain penetration.
She has collaborated
with interdisciplinary groups to investigate how nutritional supplements (phytochemicals and omega - 6 and omega - 3 fatty acids) affect menopause - associated metabolic disturbances and breast cancer in
preclinical models (cell and mouse) and clinical settings.
Having a strong R&D department
with great experience and expertise in drug development, animal
model and assay development and
preclinical efficacy evaluation, the contribution of Biomedcode has been greatly valued by our partners, as documented by our participation in several collaborative research projects.
This included 7 genes
with renal function which have never been analysed in a
preclinical model before.
Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer),
with the aim to collaborate in a structured way
with French oncology groups, research teams as well as pharmaceutical industry, by providing
preclinical models and guidance on standard operating procedures for ancillary or future studies in identified population at risk.
EOS200271 has demonstrated anti-tumor activity in multiple
preclinical tumor
models in monotherapy and in combination
with immune checkpoint inhibitors.
M1: Passive transfer studies in
preclinical model performed; Report on protection by passive therapy
with human immune IgG
Hu H, Gomero E, Bonten E, Gray JT Allay J, Wu Y, Wu J, Calabrese C, Nienhuis A, d'Azzo A.
Preclinical dose - finding study
with a liver - tropic, recombinant AAV - 2 / 8 vector in the mouse
model of galactosialidosis.
Both recent experience
with immunotherapy for clearance of Aβ in AD, and their own (and Prothena's) experience
with AS - clearing immunotherapies in animal
models, indicate that in order to be effective as disease - modifying agents when administered alone, therapies that remove proteinaceous aggregates from the brain must be initiated in the early clinical or even
preclinical stages of the disease, before the burden of other forms of aging damage becomes entrenched.
AFF 1:
Preclinical Efficacy Data AFF 1 was then tested for preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to L
Preclinical Efficacy Data AFF 1 was then tested for
preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to L
preclinical efficacy in two
models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a
model with closer neuropathological and metabolic resemblance to LBD than PD.
The phenotyping department of PHENOMIN - ICS is advancing a technical platform for functional characterization of
preclinical models of human diseases
with respect to both genetic understanding of pathophysiological mechanisms and the assessment of drug therapies.
We have recently identified which cells are uniquely responsible for the metastasis formation in OSCC, and they exhibit the following characteristics: i) they are exclusive in their ability to generate metastases; ii) they express the fatty acid translocase CD36, and express a unique lipid metabolic signature; iii) they directly link metastasis predisposition to dietary fat content; iv) they increase their metastatic initiation potency when treated
with palmitic acid; v) they are highly sensitive to CD36 inhibition, which almost completely abolishes their metastatic potential in
preclinical models (Pascual et al., Nature 2016).
With our anti-TIGIT antibody program, we saw anti-tumor efficacy and reactivation of T - cells in
preclinical models which is encouraging for the potential of this product as a monotherapy
PHILADELPHIA — In
preclinical studies using cell
models that mimicked liver cells of patients
with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS One from the Perelman School of Medicine at the University of Pennsylvania.
Standardized exploration of physiological functions, scientific and ethical considerations, study design, analysis and data management, alternative imaging method tests /
Preclinical approaches
with mouse
models, a first step toward the man, interest and limits
and affinity of antibody ACI - 5400 were characterized by a panel of methods: (i) measuring the selectivity for a specific phospho - Tau epitope known to be associated
with tauopathy, (ii) performing a combination of peptide and protein binding assays, (iii) staining of brain sections from mouse
preclinical tauopathy
models and from human subjects representing six different tauopathies, and (iv) evaluating the selective binding to pathological epitopes on extracts from tauopathy brains in non-denaturing sandwich assays.
The goal of this Center of Excellence is to better define thrombus development in patients
with cancer, test the efficacy of novel therapies, develop new
preclinical models, and create and expand biorepositories to provide a valuable resource to researchers across Cleveland Clinic.
The lab used MRS in a
preclinical study of SAPAP3 knockout mice — which
model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans
with OCRD.
«Using our
preclinical model, we will determine what existing chemotherapies can be combined
with this novel drug type to produce the best therapeutic effects,» he said.
Here we report the development and
preclinical characterization of a novel CD123 - targeting ADC, IMGN632, which utilizes a highly potent DNA - alkylating payload, resulting in an ADC
with robust
preclinical activity in multiple
models of AML.
His research group actively collaborates
with several pharmaceutical companies to provide valuable
preclinical data in animal
models for their targeted drugs.
At Sanofi I worked in a
preclinical group, working
with a team to develop a novel mouse
model.
However, ADCs that use derivatives of calicheamicin, which promotes double - stranded DNA breaks, such as GO and inotuzumab ozogamicin, 40,41 have limited activity in cells
with high multidrug resistance protein activity, a phenotype found in a significant fraction of AML patients.42 Another ADC, SGN - CD123A, comprising an engineered form of the CD123 - targeting 7G3 antibody conjugated to a synthetic pyrrolobenzodiazepine dimer, which acts via DNA crosslinking, has entered clinical trials after showing robust activity in
preclinical models of AML, including those
with multidrug resistance.33