Sentences with phrase «preclinical mouse»

Previously we reported the development of liposome - based vaccines and their efficacy and safety in preclinical mouse models for tauopathy.

Finally, we show that addition of small molecule inhibitors of eIF2α dephosphorylation to muscle stem cell cultures permits their ex vivo expansion and engraftment into a preclinical mouse model of Duchenne muscular dystrophy.

Dr. Pham is presently investigating cell therapy using a transgenic and preclinical mouse model.

Researchers suggested that other classes of inhibitors be tested in combination with ERK5 inhibitors in human colorectal cancer cells in preclinical mouse models before any patient trial can begin.

Not exact matches

«We have developed a drug candidate, a next - generation biologic medical product, and are now publishing the fantastic results from the preclinical part where wound healing was strongly accelerated in mice,» says Mia Phillipson, Professor at the Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University.

In preclinical experiments, the team injected mice with antibiotics to see if it would mitigate the effect of the bacteria.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

«The new compounds would need to work effectively in mice and pass preclinical benchmarks before they can be tried in humans,» Zimmerman said.

As reported in Nature this week, preclinical tests showed promising immune responses in both mice and monkeys.

Study leader Robert Darnell, a Howard Hughes Medical Institute (HHMI) investigator at the Rockefeller University, calls the findings «an exciting step toward a different kind of treatment approach,» but cautions that the results, from studies of mice, are preclinical.

Now, a preclinical study, from the lab of Olivier Berton, PhD, an assistant professor in the department of Psychiatry, in collaboration with Sheryl Beck, PhD, a professor in the department of Anesthesiology at Children's Hospital of Philadelphia, found that bullying and other social stresses triggered symptoms of depression in mice by activating GABA neurons, in a never - before - seen direct relationship between social stimuli and this neural circuitry.

Several research institutions and companies have vaccine and drug candidates nearly ready to test, but until now a mouse model — a critical stage in preclinical testing — has not been available.

Research in recent years has covered both preclinical basic research and the transfer of the results generated from studies of mouse models to clinically applicable techniques for treating female infertility.

The preclinical study looked at the effect of DHA on lupus lesions in the lungs and kidneys of female mice that were already genetically predisposed to the disease.

A preclinical study in mice published by Cell Press January 16th in the journal Cell reveals that drugs known as histone deacetylase inhibitors (HDACis) can enhance the brain's ability to permanently replace old traumatic memories with new memories, opening promising avenues for the treatment of posttraumatic stress disorder (PTSD) and other anxiety disorders.

Using their previously established sporadic PD mouse model, the researchers conducted both prevention and intervention preclinical studies.

The laboratory's Oncology Preclinical Services team, which offers preclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under hisPreclinical Services team, which offers preclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under hispreclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under his direction.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

Preclinical studies in mice and human cells suggested that the removal of SnCs significantly reduced the development of post-traumatic OA and related pain and created a prochondrogenic environment for new cartilage to grow and repair joints.

Mice and rats will likely always be used in preclinical trials of cancer drugs and do offer some significant advantages, Fan said.

The article, «Retrobulbar Inflammation, Adipogenesis and Acute Orbital Congestion in a Preclinical Female Mouse Model of Graves» Orbitopathy Induced by Thyrotropin Receptor Plasmid - in Vivo Electroporation,» will be published in the September issue of Endocrinology.

Fan also addressed the strengths and limitations of using mice and rats in preclinical trials of cancer drugs.

37 experts, whose European speakers involved in INFRAFRONTIER Mouse clinics, will share with you all the new approaches that will profoundly change the basic, preclinical and biopharmaceuticals researches.

A major asset of the OMC platform is the tight integration of preclinical scientists with physicians, who work side by side to comparatively assess pathogenic, diagnostic and therapeutic issues raised in patients with the mouse model counterpart.

Other humanized mice have no spontaneous phenotype and can be combined with either genetic spontaneous or inducible models of chronic inflammatory diseases yielding preclinical efficacy evaluation platforms for Rheumatoid Arthritis, Intestinal Inflammation, Psoriasis and Multiple Sclerosis.

The generation, characterization and use of transgenic mice for the preclinical efficacy evaluation of therapeutics constitute one of the main R&D activities of Biomedcode.

Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in multiple mouse tumor models.

Osimertinib showed preclinical evidence of concentrations in mouse brain tissue 5 - to 25-fold higher than in plasma, [16] and has shown greater penetration of the BBB in mouse models than gefitinib, rociletinib, or afatinib.

She has collaborated with interdisciplinary groups to investigate how nutritional supplements (phytochemicals and omega - 6 and omega - 3 fatty acids) affect menopause - associated metabolic disturbances and breast cancer in preclinical models (cell and mouse) and clinical settings.

Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.

Hu H, Gomero E, Bonten E, Gray JT Allay J, Wu Y, Wu J, Calabrese C, Nienhuis A, d'Azzo A. Preclinical dose - finding study with a liver - tropic, recombinant AAV - 2 / 8 vector in the mouse model of galactosialidosis.

The Institute's phenotyping platforms are adapted for the study of mutant mice and genetic reference populations but can also be used for preclinical studies including the validation of therapeutic targets as well as pharmacological and toxicological studies in the mouse.

To test the efficacy of J147 in a much more rigorous preclinical AD model, we treated mice using a therapeutic strategy more accurately reflecting the human symptomatic stage.

To test the efficacy of J147 in a much more rigorous preclinical Alzheimer's model, the Salk team treated mice using a therapeutic strategy that they say more accurately reflects the human symptomatic stage of Alzheimer's.

Another mouse preclinical screening trial targeted the symptomatic stage (between 9 and 11 months)[44] and a study with a plant extract [99] used 23 - to 24 - month - old mice, but to our knowledge no chemically defined AD drug candidate has been tried at the more pathologically advanced stage used in this study.

The phenotyping platforms of PHENOMIN - ICS area, adapted to study genetically modified mouse models, can also be used for preclinical studies, including the validation of therapeutic targets, as well as pharmaceutical and toxicological studies in mice.

AFF 1: Preclinical Efficacy Data AFF 1 was then tested for preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to LPreclinical Efficacy Data AFF 1 was then tested for preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to Lpreclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to LBD than PD.

Today our rich collection of arthritis mouse models is widely used for the preclinical evaluation of the efficacy of anti-arthritic pharmaceuticals and offer an ideal platform for establishing proof of concept for novel technological advances.

Collagen Antibody Induced Arthritis (CAIA) is a simple mouse model of rheumatoid arthritis that can be used for the fast preclinical efficacy evaluation of candidate therapeutic agents targeting pathogenic mechanisms and inflammatory processes of arthritis.

Title: A PET tracer for brain a2C - adrenoceptors, [11C] ORM - 13070: radiosynthesis and preclinical evaluation in rats and knock - out mice Author: E. Arponen et al..

«We have developed a drug candidate, a next - generation biologic medical product, and are now publishing the fantastic results from the preclinical part where wound healing was strongly accelerated in mice,» says Mia Phillipson.

Biomedcode is a Contract Research Organisation (CRO) providing full preclinical drug evaluation services to the pharmaceutical industry using a unique collection of mouse models of human inflammatory diseases.

Standardized exploration of physiological functions, scientific and ethical considerations, study design, analysis and data management, alternative imaging method tests / Preclinical approaches with mouse models, a first step toward the man, interest and limits

Both induced and natural Tregs were shown to reduce GVHD in mice or preclinical models (7 — 10).

Her research involves preclinical immunology and efficacy of vaccines against H5N1 pandemic influenza, malaria, and Mycobacterium tuberculosis using mouse, ferret and guinea pig models.

Biomedcode offers preclinical testing using complex mouse models closely recapitulating the complexity of human disease as they also exhibit co-developing pathologies also observed in human patients.

and affinity of antibody ACI - 5400 were characterized by a panel of methods: (i) measuring the selectivity for a specific phospho - Tau epitope known to be associated with tauopathy, (ii) performing a combination of peptide and protein binding assays, (iii) staining of brain sections from mouse preclinical tauopathy models and from human subjects representing six different tauopathies, and (iv) evaluating the selective binding to pathological epitopes on extracts from tauopathy brains in non-denaturing sandwich assays.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.

Antagonistic analogs of growth hormone - releasing hormone increase the efficacy of treatment of triple negative breast cancer in nude mice with doxorubicin; A preclinical study

A preclinical study in mice, published earlier this week in Nature, showed that a single dose of ZPIV generated an immune response, which protected the mice against subsequent Zika challenge with a Brazilian strain of the virus.