The term
"preclinical phase" refers to the initial stage of testing new medical treatments or drugs. During this phase, experiments are conducted in laboratories and with animals to gather information on the new treatment's safety and effectiveness before it is tested on humans.
Full definition
The American Heart Association / American College of Cardiology (AHA / ACC) has categorized HF into three stages (A, B, C / D) with A and B being
preclinical phases, meaning they are characterized by elevated risk of HF without the actual condition.
In favorable cases, this will result in short - circuiting of
the preclinical phase of the drug development [3, 4].
In
the preclinical phase, metabolic profiling helps predict drug effects, while in clinical phases it can be used to establish personalized treatment strategies.
Of the other candidates, one is in Phase 1 and the remaining three are in
the preclinical phase.
Treatment timing was in
the preclinical phase (no outward symptoms and Stage B2 heart disease) instead of clinical phase (patients exhibiting clinical signs and at Stage C heart disease); and