Sentences with phrase «preclinical phases»

The most rational framework with which to discover interventions that prevent or delay the initial onset of symptoms is a biologically based definition of the disease that encompasses both the clinical and the preclinical phases.

The American Heart Association / American College of Cardiology (AHA / ACC) has categorized HF into three stages (A, B, C / D) with A and B being preclinical phases, meaning they are characterized by elevated risk of HF without the actual condition.

In favorable cases, this will result in short - circuiting of the preclinical phase of the drug development [3, 4].

In the preclinical phase, metabolic profiling helps predict drug effects, while in clinical phases it can be used to establish personalized treatment strategies.

Treatment timing was in the preclinical phase (no outward symptoms and Stage B2 heart disease) instead of clinical phase (patients exhibiting clinical signs and at Stage C heart disease); and

Not exact matches

Targacept needs to succeed in only two of its phase III trials to gain approval, says Merouane Bencherif, head of preclinical research at the company.

Past studies have suggested depression and other neuropsychiatric symptoms may be predictors of AD's progression during its «preclinical» phase, during which time brain deposits of fibrillar amyloid and pathological tau accumulate in a patient's brain.

Independent of these preclinical studies, Clementia Pharmaceuticals is currently conducting phase 2 clinical trials in individuals with FOP, based on the 2011 preclinical results published by Pacifici and Iwamoto.

In his current role, he combines population research and functional genomics strategies to inform drug development from preclinical through phase 3 trials.

Since eye and vision research can be conducted noninvasively, advancement of trials from the preclinical to the clinical phase could be relatively fast.

Based on these preclinical findings, CRI provides a seed grant for a phase I clinical trial to test the strategy in patients with metastatic renal cell carcinoma.

She is CEO of PsychoGenics Inc., a profitable preclinical CNS service company, CEO of PGI Drug Discovery LLC, a company engaged in psychiatric drug discovery with three partnered Phase II clinical programs and Adjunct Associate Professor of Neuroscience at Mount Sinai School of Medicine, Dr. Leahy has more than 25 years of experience in drug discovery, clinical develop and business development for pharmaceutical and biotechnology companies, including extensive knowledge of technology assessment, licensing, mergers and acquisitions, and strategic planning.

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy - refractory, advanced colorectal cancer.

The Wake Forest Institute of Regenerative Medicine (WFIRM) has a unique infrastructure that provides facilities and expertise for translational studies, from basic preclinical findings all the way through Phase 2 clinical trials.

This has involved preclinical and clinical evaluation in Phase I and Phase I / II studies that have characterized tumor antigen expression and immune responses in patients.

Together with the research and clinical resources of the nation's leading cancer hospital, we have the ability to take a program from a research hypothesis all the way to a clinical candidate supported by robust preclinical data, and into early phase clinical studies in well - defined patient populations.

It is currently being evaluated for safety and efficacy in preclinical models with a Phase I trial expected to begin in 2019.

«The initiation of the NPT088 Phase 1b trial is supported by a substantial preclinical development program and the recent successful completion of a Phase 1a study in healthy volunteers.

Roche (SIX: RO, ROG; OTCQX: RHHBY) and Prothena Corporation plc (NASDAQ: PRTA), announced today that they have entered into a worldwide collaboration to develop and commercialize antibodies that target alpha - synuclein, including PRX002... which is currently in preclinical development and is expected to enter Phase 1 clinical trials in patients with Parkinson's disease in 2014.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

So far, JQ1 has been relatively well tolerated in both preclinical studies and in early phase clinical trials for cancer patients.

In his role as IDRI's Chief Medical Officer, Corey is developing and leading all clinical trial programs for IDRI from preclinical to Phase III, including oversight and management of data functions.

Overall, SR - Tiget represents a multi-disciplinary research environment, which provides a unique blend of scientific expertise in the development of innovative gene and cell therapy strategies, access to relevant preclinical models to evaluate their efficacy and safety, as well as competence in conducting early phase clinical trials.

Oral medications can be initiated in the preclinical (asymptomatic) phase of dilated cardiomyopathy and in some cases, these medications can delay the progression of the disease to the development of congestive heart failure.

AGTC plans to use the net proceeds of the offering to fund preclinical investigation and Phase 1/2 trials of potential product candidates for treatment of wet AMD; to expand its manufacturing capabilities and create a pilot manufacturing group; to in - license, acquire or invest in complementary gene therapy, technologies, products or assets; and for working capital and other general corporate purposes.