Sentences with phrase «preclinical research at»

He also served as Executive Vice President for Worldwide Discovery and Preclinical Research at Merck & Co..

Over the course of its development, PNP has secured grants from the National Institutes of Health of approximately $ 10 million to support preclinical research at Southern Research Institute and UAB.

Targacept needs to succeed in only two of its phase III trials to gain approval, says Merouane Bencherif, head of preclinical research at the company.

Not exact matches

Looking at sixty - seven recent drug discovery projects based on preclinical cancer biology research, they found that in more than 75 percent of cases the published data did not match up with their in - house attempts to replicate.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

• Changes may be afoot for biomedical scientists as a result of efforts at the National Institutes of Health (NIH) to improve the reproducibility of preclinical research.

The researchers reprogrammed the cells to create induced pluripotent stem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinicalResearch Center; the use of this facility is an important step in the process as preclinical research moves toward human clinicalresearch moves toward human clinical trials.

For example, Matt Krause, director of human resources at CV Therapeutics, says, «Our research programs include multiple, cutting - edge cardiovascular product candidates in various stages of clinical trials and preclinical programs, all of which rely heavily on the contributions from our many B.S. - and M.S. - level scientists.»

«To better understand safety issues, we are making efforts to employ more modern investigational, molecular approaches to safety assessment — and increase our safety testing work force by about 10 percent,» says Phil Bentley, vice president and global head of preclinical safety at Novartis Institutes for BioMedical Research in New York City.

The preclinical study was led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

Recently published in the journal eLife and featured in a poster session at this year's American Association for Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).

The Walter Reed Army Institute of Research (WRAIR) and collaborators at the Beth Israel Deaconess Medical Center and Harvard Medical School have completed a promising preclinical study of two Zika vaccine candidates that suggests that an effective human vaccine will be achievable.

The current study is built on more than 20 years of preclinical research on memory codes led by Sam Deadwyler, Ph.D., professor of physiology and pharmacology at Wake Forest Baptist, along with Hampson, Berger and Song.

Scientists at the University of California at San Diego currently are studying MW108 in preclinical cancer immunology research.

Formerly a research leader at CHOP, High pursued groundbreaking preclinical investigations in hemophilia B gene therapy and provided scientific expertise to previous gene therapy trials in hemophilia and other genetic disorders at CHOP before moving to Spark Therapeutics, which was spun off from CHOP in 2013.

«The pace of preclinical and early clinical development for Zika vaccines is unprecedented,» said Barouch, corresponding author and director of the Center for Virology and Vaccine Research at BIDMC.

«We are at a point in our research where we have validated the efficacy of this combination treatment approach in preclinical animal models, and we now need to define its safety through toxicology and pharmacology studies,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Mresearch where we have validated the efficacy of this combination treatment approach in preclinical animal models, and we now need to define its safety through toxicology and pharmacology studies,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular MResearch and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Mresearch program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Medicine.

The Herbert Irving Comprehensive Cancer Center at NewYork - Presbyterian / Columbia University Medical Center encompasses preclinical and clinical research, treatment, prevention, and education efforts in cancer.

These encouraging preclinical results suggest the compound, known as GS - 5734, should be further developed as a potential treatment, according to research findings to be presented tomorrow at the IDWeek conference.

Explore our specialized research portfolio of unique solutions to clinical and preclinical research problems developed by experts at Wake Forest Baptist Medical Center.

PHILADELPHIA --(July 11, 2017)-- Researchers at The Wistar Institute, an international leader in biomedical research in the fields of cancer, immunology and infectious diseases, with collaborators at Indiana University Melvin and Bren Simon Cancer Center and Syndax Pharmaceuticals, Inc., (Nasdaq: SNDX) announce the results of a preclinical study demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

Katherine W. Klinger, PhD, Senior Vice President for Genetics and Genomics at the Genzyme Corporation, and Assistant Clinical Professor in the Department of Pediatrics at the University of Connecticut School of Medicine suggested that for an orphan disease it may be necessary to use multiple animal models in the preclinical research stage, because one animal model may not fully recapitulate the human disease.

PNP Therapeutics, Inc. — a company based on a gene - therapy technology developed by scientists at Southern Research Institute and the University of Alabama at Birmingham (UAB)-- has found an approach that has abolished otherwise unmanageable human cancers in preclinical rodent studies.

Seres Therapeutics, Inc. (NASDAQ: MCRB) today announced that new preclinical data supporting the development of microbiome therapeutics for immuno - oncology (leveraging gut microbiota to impact tumor immunotherapy) 1 will be presented today by Sceneay et al in the late breaking poster session at the 2018 American Association for Cancer Research Annual Meeting (AACR) in Chicago.

Faulty mitochondria contribute to a range of diseases and a research group working towards the use of mitochondrial donation techniques for women at risk of passing on those diseases to their children have described their preclinical work in the journal Nature.

Dr. Bolen will oversee all aspects of R&D at Moderna, including discovery research, preclinical and clinical development, and clinical operations.

It enables scientists at Moderna's ventures and New Venture Labs, as well as our biopharma partners, to digitally design and order mRNA constructs for use in discovery research and preclinical studies through an encrypted and secure portal.

Under the terms of the partnership, Moderna will sponsor research grants for scientists at both institutions to conduct preclinical research with novel mRNA Therapeutics ™.

Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer), with the aim to collaborate in a structured way with French oncology groups, research teams as well as pharmaceutical industry, by providing preclinical models and guidance on standard operating procedures for ancillary or future studies in identified population at risk.

Gosselies, Belgium - April 3, 2017 - iTeos Therapeutics SA, a biotechnology company developing novel cancer immunotherapies, will present preclinical data for its A2A receptor antagonist, which inhibits the immune suppressive function of adenosine, at the American Association for Cancer Research (AACR) Annual Meeting.

PHILADELPHIA — In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS One from the Perelman School of Medicine at the University of Pennsylvania.

Jesse Erasmus is a postdoctoral scientist in the Preclinical & Translational Research group at IDRI.

Thus, to support and enhance our collaborations with industry partners dedicated to improving the lives of children with nervous system disorders, the Translational Neuroscience Center (TNC) at Boston Children's Hospital has recruited Robin Kleiman, PhD, as the head of preclinical research.

The researchers are reporting preclinical findings for a potential two - treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer at the American Association for Cancer Research Annual...

Performs genome - wide profiling of vector integration sites as readout of cell growth at clonal level, in basic research studies and technology development, in preclinical safety studies and in gene therapy treated patients.

Researchers at the Sanford Consortium for Regenerative Medicine have broad scientific goals in basic and preclinical research, as well as preclinical development of discoveries.

He was introduced to radiopharmaceutical development as a postdoctoral research associate and then as a staff scientist in the department of radiology at Washington University School of Medicine, where he developed several preclinical imaging agents to study brain tumors, atherosclerosis and Alzheimer's disease.

Wake Forest Innovations can help you solve these medical problems by getting you access to the researchers and clinicians at Wake Forest Baptist Medical Center to advance your preclinical or clinical research — from stroke and epilepsy to pain and addiction and everything in between.

The Duke Center for Integrative Health Research (DCIHR) is a multidisciplinary center of innovative preclinical and clinical research aimed at optimizing health and well - being using methodologies based in complementary and integrative medicine, nutrition, fitness, and health behaviorResearch (DCIHR) is a multidisciplinary center of innovative preclinical and clinical research aimed at optimizing health and well - being using methodologies based in complementary and integrative medicine, nutrition, fitness, and health behaviorresearch aimed at optimizing health and well - being using methodologies based in complementary and integrative medicine, nutrition, fitness, and health behavior change.

At Vets Plus, Dr. Ajay leads new product development initiatives, overseeing all preclinical and clinical trials and research.