"Preclinical results" refer to the findings and data obtained from scientific experiments conducted on animals or in lab settings before moving on to human clinical trials.
Full definition
These encouraging
preclinical results suggest the compound, known as GS - 5734, should be further developed as a potential treatment, according to research findings to be presented tomorrow at the IDWeek conference.
Independent of these preclinical studies, Clementia Pharmaceuticals is currently conducting phase 2 clinical trials in individuals with FOP, based on the 2011
preclinical results published by Pacifici and Iwamoto.
«On the basis of the promising
preclinical results here, improving outcomes for this deadly malignancy could be achieved simply by supplementing existing therapies that work well against the majority of tumor cells with agents that sensitize the CA125 - negative cells to carboplatin.»
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Preclinical results suggest the «vitamin D brake» is highly efficacious and led us to believe that the time is right to consider a trial in the context of chronic liver disease,» says Evans, a Howard Hughes Medical Institute Investigator and holder of the March of Dimes Chair in Molecular and Developmental Biology.
Based on these
promising preclinical results, Dr. Amaravadi and his team have already launched a clinical trial for patients with advanced BRAF mutant melanoma to see how well - tolerated HCQ is with the BRAF inhibitor vemurafenib.
If
these preclinical results hold true in humans, this would allow for a less frequent dosing regimen and possibly fewer troublesome side effects that plague conventional lithium therapy.
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The preclinical results in our animal models are really exciting and have provided the momentum for me to continue on this project, even after Novartis indicated that it no longer wished to maintain this collaboration.»
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These preclinical results show the potential of our compound to target the inhibition of the A2A receptor in the challenging context of tumor - like adenosine concentrations.