Sentences with phrase «preclinical settings»

An editorial in the same issue of the journal notes that drug - based treatments for liver cancer are limited and that the UT Southwestern study showed «truly remarkable results that should prompt further research under preclinical settings, given its potential to lead to a paradigm shift in treatment.»

The scientists are now trying to identify antibodies that would be effective in humans, and a company has been formed to move the work towards translation and determine which models are most useful in a preclinical setting.

Within a preclinical setting, such imaging allows disease states to be observed and measured non-invasively within the whole animal, bridging the gap between drug discovery and human clinical trials.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

Not exact matches

The first move sets Takeda up to work on development of FIN - 524, a preclinical therapy that contains cultured bacteria strains and which could theoretically be used to treat gut diseases.

«[A.I.] can help analyze large data sets from sources such as clinical trials, health records, genetic profiles, and preclinical studies; within this data, it can recognize patterns and trends and develop hypotheses at a much faster rate than researchers alone,» says Deloitte.

The attendees agreed on a common set of Principles and Guidelines in Reporting Preclinical Research (www.nih.gov/about/reporting-preclinical-research.htm) that list proposed journal policies and author reporting requirements to promote transparency and reproducibility.

Recently published in the journal eLife and featured in a poster session at this year's American Association for Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).

Translational research, which applies findings to a health care setting, accounted for 33.3 per cent of this spend, compared with 1997 - 2010 when funding was almost entirely preclinical.

A division of preclinical innovation will house a $ 44 million set of mostly intramural programs, including small - molecule screening and drug development for rare diseases.

She has collaborated with interdisciplinary groups to investigate how nutritional supplements (phytochemicals and omega - 6 and omega - 3 fatty acids) affect menopause - associated metabolic disturbances and breast cancer in preclinical models (cell and mouse) and clinical settings.

Resources include extensive genomic and drug sensitivity data sets, orthotopic xenografts and preclinical models.

Under an existing collaborative research arrangement, Sanofi and Immune Design have generated a large set of preclinical data demonstrating that certain formulations within GLAAS, when given prophylactically or therapeutically, can shift the immune responses in a way that may result in significant protection and reduction from allergy symptoms.