Sentences with phrase «preclinical studies as»

ABSTRACT: Craving, defined as the subjective experience of an urge or desire to use substances, has been identified in clinical, laboratory, and preclinical studies as a significant predictor of substance use, substance use disorder, and relapse following treatment for a substance use disorder.

Not exact matches

«[A.I.] can help analyze large data sets from sources such as clinical trials, health records, genetic profiles, and preclinical studies; within this data, it can recognize patterns and trends and develop hypotheses at a much faster rate than researchers alone,» says Deloitte.

Results from a preclinical study conducted in collaboration with researchers at Beth Israel Deaconess Medical Center evaluating the combination of a proprietary investigational oral toll - like receptor 7 agonist, GS - 9620, and a proprietary investigational broadly neutralizing antibody, as part of an HIV eradication strategy.

In preclinical studies, oncolytic herpes simplex viruses seemed especially promising, as they naturally infect dividing brain cells.

«These results provide the basis for the potential implementation of 5 - LO - inhibitors as stem cell therapeutic agents for a sustained AML cure, although this must be investigated further in preclinical and clinical studies in humans,» explains Dr. Ruthardt.

Researcher Omkar Patkar said the preclinical study is the first step towards fast tracking pindolol into human clinical studies as a treatment option for AUDs.

A preclinical study in mice published by Cell Press January 16th in the journal Cell reveals that drugs known as histone deacetylase inhibitors (HDACis) can enhance the brain's ability to permanently replace old traumatic memories with new memories, opening promising avenues for the treatment of posttraumatic stress disorder (PTSD) and other anxiety disorders.

Of note, nearly 38 percent of people between ages 65 to 75 years and 43 percent of those older than age 75 years had evidence of preclinical HF stage B. Additionally, 32 percent of people less than 55 years of ages were classified as stage A HF,» explained corresponding author Vanessa Xanthakis, PhD, assistant professor of medicine and biostatistics at BUSM and an Investigator for the Framingham Heart Study.

«The next step is to perform preclinical studies with specific inhibitors of HDAC11 alone and in tandem with other existing immunotherapies, such as anti-PD1 / anti-PDL1 antibodies, in order to find the most potent combination.

As an established, recognized research facility, AGI has assisted our partners in conducting preclinical primate research studies in a variety of areas.

Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in multiple mouse tumor models.

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

Previosly in a preclinical study BRAF inhibitor - resistant mutated BRAF melanoma cells were developed as an experimental model system to mimic BRAF inhibitor - resistant melanoma patients and to study the mechanisms of resistance.

It enables scientists at Moderna's ventures and New Venture Labs, as well as our biopharma partners, to digitally design and order mRNA constructs for use in discovery research and preclinical studies through an encrypted and secure portal.

Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer), with the aim to collaborate in a structured way with French oncology groups, research teams as well as pharmaceutical industry, by providing preclinical models and guidance on standard operating procedures for ancillary or future studies in identified population at risk.

The Institute's phenotyping platforms are adapted for the study of mutant mice and genetic reference populations but can also be used for preclinical studies including the validation of therapeutic targets as well as pharmacological and toxicological studies in the mouse.

[13] Highlighting this risk in the PD / AS context, a preclinical study using a nitrated AS species similar to one found in patient LB as an active vaccine antigen developed worrisome autoimmunitAS context, a preclinical study using a nitrated AS species similar to one found in patient LB as an active vaccine antigen developed worrisome autoimmunitAS species similar to one found in patient LB as an active vaccine antigen developed worrisome autoimmunitas an active vaccine antigen developed worrisome autoimmunity.

The phenotyping platforms of PHENOMIN - ICS area, adapted to study genetically modified mouse models, can also be used for preclinical studies, including the validation of therapeutic targets, as well as pharmaceutical and toxicological studies in mice.

Such features as its actual target antigen were revealed only inconsistently and through secondary sources (such as a series of Michael J Fox Foundation blog posts and a third - party review article [14]-RRB-, and only hints of their preclinical studies with the agent were disclosed (mostly [9,11]-RRB-.

As the Global HIV Vaccine Product Manager for the US Army, Dr. Ake advances the development of HIV vaccine candidates in preclinical and early clinical studies.

Trials such as the Anti-Amyloid in Asymptomatic Alzheimer's Study, or A4 Study, are now focusing on enrolling cognitively normal participants who have biomarkers suggestive of «preclinical AD,» in order to delay the onset of cognitive impairments.

Ward et al. highlight results from molecular and preclinical studies, discuss clinical trial results to date, describe ongoing investigations, and assess novel approaches for the enhancement of MSC based cardiac regeneration, such as genetic modification.

Performs genome - wide profiling of vector integration sites as readout of cell growth at clonal level, in basic research studies and technology development, in preclinical safety studies and in gene therapy treated patients.

Juhani Eskola's areas of expertise can be summarised as follows: Public health, Vaccinology, Immunology, pharmaceutical industry, Preclinical toxicology studies, Clinical trials.

«We are encouraged by the preclinical data emerging on SRK - 015, including the effects upon fast - twitch muscle fibers that are particularly relevant for SMA as well as its selectivity profile, which may be very important when considering chronic therapy in children,» said Karen S. Chen, PhD, Chief Scientific Officer of the SMA Foundation and a co-author of the study being presented at the Cure SMA Annual Conference.

Duke s research will use patented multielectrode technology to directly measure the activity of hundreds of neurons to study brain dynamics in unique preclinical models of diseases such as Parkinson s and schizophrenia.

The in vivo - like pathophysiology observed in this system suggests that it might serve as a useful tool for evaluating human - relevant renal toxicity in preclinical safety studies.

He was introduced to radiopharmaceutical development as a postdoctoral research associate and then as a staff scientist in the department of radiology at Washington University School of Medicine, where he developed several preclinical imaging agents to study brain tumors, atherosclerosis and Alzheimer's disease.

The study investigated the effect of dietary fat (classified as total, saturated, monounsaturated, polyunsaturated, omega 6, omega 3 and trans) on a range of preclinical and clinical outcomes in women having IVF.

These reference standards and limited feeding trials are, like the basic pharmacology and preclinical testing of pharmaceuticals, not perfect, and it is certainly likely that advances in our understanding of dogs» nutritional needs as well as epidemiologic studies of dogs fed commercial diets will uncover changes that need to be made in the formulations of commercial diets.

Consistent with preclinical studies, adults with depression have been reported to have multiple alterations of the hypothalamic pituitary adrenal axis (9), increased cerebrospinal fluid corticotropin - releasing hormone (10), elevated cerebrospinal fluid norepinephrine concentration (11), decreased cortical γ - aminobutyric acid measured in vivo using proton magnetic resonance spectroscopy (12), and multiple indicators of altered serotonin (5 - HT) functioning (13), including reduced serotonin transporter (5 - HTT) availability as evidenced by reduced [123I] β - CIT spect binding (14).