Sentences with phrase «preclinical studies through»

It enables scientists at Moderna's ventures and New Venture Labs, as well as our biopharma partners, to digitally design and order mRNA constructs for use in discovery research and preclinical studies through an encrypted and secure portal.

Not exact matches

Through a rigorous pharmaceutical approach, Gnosis carries out a seamless flow of operations, from product concept to research and development, preclinical and clinical studies, regulatory filing and Intellectual properties, manufacturing and distribution standing alongside customers.

«We are at a point in our research where we have validated the efficacy of this combination treatment approach in preclinical animal models, and we now need to define its safety through toxicology and pharmacology studies,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Medicine.

Through these endeavors and my current research program, I am actively engaged in fostering collaborations with academic, non-profit and industry partners to conduct large - scale rodent behavioral evaluations and preclinical studies.

PHILADELPHIA --(July 11, 2017)-- Researchers at The Wistar Institute, an international leader in biomedical research in the fields of cancer, immunology and infectious diseases, with collaborators at Indiana University Melvin and Bren Simon Cancer Center and Syndax Pharmaceuticals, Inc., (Nasdaq: SNDX) announce the results of a preclinical study demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

Through the collaboration, Lysogene, UMMS and AU will develop IND - supporting preclinical studies in GM1 - gangliosidosis using AAV gene therapy technology.

These potential indications are currently being evaluated through preclinical studies.

The Wake Forest Institute of Regenerative Medicine (WFIRM) has a unique infrastructure that provides facilities and expertise for translational studies, from basic preclinical findings all the way through Phase 2 clinical trials.

Such features as its actual target antigen were revealed only inconsistently and through secondary sources (such as a series of Michael J Fox Foundation blog posts and a third - party review article [14]-RRB-, and only hints of their preclinical studies with the agent were disclosed (mostly [9,11]-RRB-.

Host: Dr. Tim Murphy Speaker: Dr. Leonard Khiroug, Neurotar Title: In vivo two - photon imaging of fluorescently - labeled macromolecule penetration through blood - brain barrier: applications in Pharma preclinical studies

The endocannabinoid system regulates energy homeostasis through G protein — coupled cannabinoid - 1 receptors5, 6 located in the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorders.

These encouraging results led us to believe that pimobendan could be effective in preclinical mitral valve disease and that the investigation of this through the EPIC Study was useful and worthwhile.