Sentences with phrase «preclinical studies with»

Such features as its actual target antigen were revealed only inconsistently and through secondary sources (such as a series of Michael J Fox Foundation blog posts and a third - party review article [14]-RRB-, and only hints of their preclinical studies with the agent were disclosed (mostly [9,11]-RRB-.

«The next step is to perform preclinical studies with specific inhibitors of HDAC11 alone and in tandem with other existing immunotherapies, such as anti-PD1 / anti-PDL1 antibodies, in order to find the most potent combination.

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.

Not exact matches

Results from a preclinical study conducted in collaboration with researchers at Beth Israel Deaconess Medical Center evaluating the combination of a proprietary investigational oral toll - like receptor 7 agonist, GS - 9620, and a proprietary investigational broadly neutralizing antibody, as part of an HIV eradication strategy.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

«Even though they're inactivating the virus, it's still there,» says Ross, whose laboratory worked with Novavax during its preclinical studies, when the start - up was in need of laboratory facilities.

The new data builds off several preclinical studies supporting the use of ibrutinib with CAR therapy.

Independent of these preclinical studies, Clementia Pharmaceuticals is currently conducting phase 2 clinical trials in individuals with FOP, based on the 2011 preclinical results published by Pacifici and Iwamoto.

«In preclinical studies, we've shown that when a MEK inhibitor was combined with an Akt inhibitor, which affects another cancer - related pathway, the results were better than when using MEK alone,» he said.

In preclinical studies, hypothermia and anti-oxidant treatment with N - acetylcysteine (NAC) are neuroprotective following neonatal hypoxic ischemia in females, but less so in males.

Jenkins and her team plan to build upon these results with preclinical and clinical studies aimed at understanding the injury mechanisms underlying hypoxic ischemia and how they differ in males and females.

Now, a preclinical study, from the lab of Olivier Berton, PhD, an assistant professor in the department of Psychiatry, in collaboration with Sheryl Beck, PhD, a professor in the department of Anesthesiology at Children's Hospital of Philadelphia, found that bullying and other social stresses triggered symptoms of depression in mice by activating GABA neurons, in a never - before - seen direct relationship between social stimuli and this neural circuitry.

A preclinical study in mice published by Cell Press January 16th in the journal Cell reveals that drugs known as histone deacetylase inhibitors (HDACis) can enhance the brain's ability to permanently replace old traumatic memories with new memories, opening promising avenues for the treatment of posttraumatic stress disorder (PTSD) and other anxiety disorders.

The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.

«The model for preclinical studies to predict with great accuracy which drugs would work in the clinic was developed a decade ago,» says Dr. Chesi.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

The current study is built on more than 20 years of preclinical research on memory codes led by Sam Deadwyler, Ph.D., professor of physiology and pharmacology at Wake Forest Baptist, along with Hampson, Berger and Song.

«Preclinical studies suggest a possible benefit of estrogen therapy when combined with exercise to increase strength and performance and to prevent the loss of muscle mass, but the role of estrogen in muscle mass is not yet clear for postmenopausal women,» says Dr. JoAnn Pinkerton, executive director of NAMS.

We didn't have $ 20,000, which is what we needed to do the preclinical studies required for working with people.

Through these endeavors and my current research program, I am actively engaged in fostering collaborations with academic, non-profit and industry partners to conduct large - scale rodent behavioral evaluations and preclinical studies.

This, along with preclinical studies showing that D3 receptor antagonists interfere with drug seeking and cue - and stress - induced reinstatement (68), suggest that up - regulated D3 receptor signaling in midbrain might contribute to drug craving and to decreased sensitivity to reward in marijuana abusers (see below).

UNITY has completed a rigorous screening and preclinical testing process of candidate drugs, discovered in this study, and is launching a new clinical trial to assess its first drug, for patients with osteoarthritis of the knee this year.

PHILADELPHIA --(July 11, 2017)-- Researchers at The Wistar Institute, an international leader in biomedical research in the fields of cancer, immunology and infectious diseases, with collaborators at Indiana University Melvin and Bren Simon Cancer Center and Syndax Pharmaceuticals, Inc., (Nasdaq: SNDX) announce the results of a preclinical study demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

An earlier preclinical study found that rhesus monkeys that were vaccinated with ZPIV developed a strong immune response and were protected against two strains of Zika virus.

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

Preclinical studies suggested poor bioavailability with a consequent in vivo ineffectiveness for compound 182a [2, 97], while compound 182b entered clinical trials, unfortunately its development was soon suspended [98, 99].

Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer), with the aim to collaborate in a structured way with French oncology groups, research teams as well as pharmaceutical industry, by providing preclinical models and guidance on standard operating procedures for ancillary or future studies in identified population at risk.

M1: Passive transfer studies in preclinical model performed; Report on protection by passive therapy with human immune IgG

Together with the research and clinical resources of the nation's leading cancer hospital, we have the ability to take a program from a research hypothesis all the way to a clinical candidate supported by robust preclinical data, and into early phase clinical studies in well - defined patient populations.

Hu H, Gomero E, Bonten E, Gray JT Allay J, Wu Y, Wu J, Calabrese C, Nienhuis A, d'Azzo A. Preclinical dose - finding study with a liver - tropic, recombinant AAV - 2 / 8 vector in the mouse model of galactosialidosis.

Moreover, in another study, preclinical diabetic cardiomyopathy was common in diabetic patients, with female sex being the only independent predictor of LV hypertrophy (301).

In collaboration with the University of Massachusetts Medical School (UMMS) and Auburn University (AU), Lysogene is developing IND - supporting preclinical studies using AAV gene therapy technology to translate the initial proof of concept into a viable drug development program to the benefit of patients in urgent need.

This study is a beautiful example of multidisciplinary team science at partnering academic institutions advancing a life - saving therapeutic from the laboratory, to preclinical studies, deftly though complex regulatory pathway, to the clinic and — with final FDA approval — hopefully into the marketplace.

Another mouse preclinical screening trial targeted the symptomatic stage (between 9 and 11 months)[44] and a study with a plant extract [99] used 23 - to 24 - month - old mice, but to our knowledge no chemically defined AD drug candidate has been tried at the more pathologically advanced stage used in this study.

PHILADELPHIA — In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS One from the Perelman School of Medicine at the University of Pennsylvania.

Standardized exploration of physiological functions, scientific and ethical considerations, study design, analysis and data management, alternative imaging method tests / Preclinical approaches with mouse models, a first step toward the man, interest and limits

In 2008, several CRI investigators were part of a multi-institutional preclinical study showing that treatment with the immune activating molecule interleukin 15 (IL - 15), when complexed with its receptor, could trigger rapid regression of established pancreatic cancers and significantly prolong survival.

Moussa conducted the preclinical research that led to the discovery of nilotinib for the treatment of neuro - degenerative diseases, then partnered with Pagan for the clinical study.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.

Antagonistic analogs of growth hormone - releasing hormone increase the efficacy of treatment of triple negative breast cancer in nude mice with doxorubicin; A preclinical study

A preclinical study in mice, published earlier this week in Nature, showed that a single dose of ZPIV generated an immune response, which protected the mice against subsequent Zika challenge with a Brazilian strain of the virus.

«The findings of this preclinical study contribute significantly to our understanding of SMA and provide further evidence suggesting that our strategy to upregulate SMN with small molecules could be effective,» said Loren Eng, President of the SMA Foundation.

The Walter Reed Army Institute of Research (WRAIR), in collaboration with the Beth Israel Deaconess Medical Center (BIDMC), has completed a second round of preclinical studies on a promising Zika... Read More

Preclinical animal studies have shown a reduction in alcohol consumption when with kudzu root isoflavone treatment.

These preclinical studies have led to a clinical trial for patients with glioblastoma multiforme (www.clinicaltrials.gov NCT02046187).

It should also be noted that preclinical and clinical studies provide evidence that six herbal medicines may have beneficial effects for women with polycystic ovarian syndrome symptoms (Arentz 2014), these being:

Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial.

Effect of pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: the EPIC Study - a randomized clinical trial.