Sentences with phrase «preclinical work with»

Not exact matches

«What we discovered in our preclinical work is evidence of how groups of neurons coordinate and cooperate with each other in a very particular way that gives us deeper insight into how the brain is controlling the arm,» Shenoy said.

«Even though they're inactivating the virus, it's still there,» says Ross, whose laboratory worked with Novavax during its preclinical studies, when the start - up was in need of laboratory facilities.

Combining their strategy with an existing immunotherapy treatment that works by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival in preclinical models for melanoma.

But in preclinical research — work with animals and cells — the preference for males has remained steadfast.

«The model for preclinical studies to predict with great accuracy which drugs would work in the clinic was developed a decade ago,» says Dr. Chesi.

The group plans to continue exploring the mechanics of SF3B1 while also pushing forward with the preclinical work needed to form the rational basis for targeting this gene in patients with advanced mucosal melanoma.

We didn't have $ 20,000, which is what we needed to do the preclinical studies required for working with people.

Hua's extensive work in Krainer's lab, in collaboration with Ionis, led to the identification and preclinical development of nusinersen, a snippet of modified RNA called an antisense oligonucleotide that intervenes in the splicing process to ensure that SMN2 expresses the full - length SMN protein.

Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms in younger children.

A major asset of the OMC platform is the tight integration of preclinical scientists with physicians, who work side by side to comparatively assess pathogenic, diagnostic and therapeutic issues raised in patients with the mouse model counterpart.

The $ 1 million grant will be used for preclinical trial work with the goal of submitting an Investigational New Drug application to the FDA to begin clinical trials.

Our group is specifically working on improvement of islet isolation and transplantation protocols in clinical practice and the development of novel therapeutic options in the field of beta cell replacement with a clear translational «bench to bedside» approach by linking experimental research with preclinical and clinical work:

Our researcher received a proof - of - concept grant from the Washington Life Sciences Discovery Fund, and worked with Washington State University and Malignext to conduct preclinical trials that produced results that will be helpful in future preclinical and clinical trials.

«We are excited to support the preclinical and clinical development work with the PEC - Direct product candidate, given its potential to help the type 1 diabetes patients with the most urgent medical need, those at high risk of life - threatening acute complications.

Preclinical work on the vaccine is being conducted with long - term HIV vaccine collaborators at the Beth Israel Deaconess Medical Center, Harvard Medical School.

This preclinical work led to the development of a novel anti-androgen ARN - 509, a small - molecule inhibitor discovered in collaboration with UCLA chemist Michael Jung, which targets the increased levels of androgen receptor found in hormone - refractory disease.

New UC developments will contribute to the three categories of research CIRM hopes to establish: basic stem cell research and discovery, preclinical and clinical research, and preclinical development; centers of excellence which will work with any duel combination of stem cell discovery, clinical research and preclinical development; and special programs which will work with specialized research programs.

The Delaney Collaboratory to Cure HIV - 1 Infection by Combination Immunotherapy (BEAT - HIV Collaboratory) is a consortium of more than 30 top HIV researchers from leading academic research institutions working with government, nonprofit organizations, and industry partners to test combinations of several novel immunotherapies under new preclinical research and clinical trials.

At Sanofi I worked in a preclinical group, working with a team to develop a novel mouse model.

The past century has unveiled a plethora of preclinical data that has suggested the potential of a ketogenic diet as an aid in cancer treatment.7, 8 The benefits of a ketogenic diet, and dietary manipulation in general, may be a potent adjunct to current cancer treatments by synergistically working with chemotherapy and radiation therapy to starve cancer cells, leaving them more susceptible to damage from these treatments.7 - 10