Sentences with phrase «precursor cell transplantation»

The major gains in behavioral recovery and neuronal survival achieved by pre-differentiation of glial precursors to specific, beneficial astrocytic cell types prior to transplantation stresses the need to consider such manipulations as a critical component in the optimization of stem / precursor cell transplantation based therapies.

While it may be that precursor cell transplantation is of potential use in astrocyte replacement in neurological disorders such as ALS [56], our results demonstrate the importance of determining whether direct transplantation of astrocytes themselves provides greater benefit.

Not exact matches

In light of the modest benefits obtained with transplantation of rodent astrocytes isolated directly from the immature CNS [49]--[53], however, our present and earlier studies [14], [57] suggest that it is necessary instead to transplant astrocytes generated from precursor cells in vitro in order to optimize benefit.

One of the striking differences in outcome between our studies and work on oligodendrocyte and oligodendrocyte - precursor replacement lies in the finding that differentiation of precursor cells into a specific astrocyte subtype prior to transplantation provides a much greater level of benefit than transplantation of the precursor cells themselves.

These results provide a defined population of human astrocytes suitable for further pre-clinical development for treatment of SCI, and demonstrate that pre-differentiation into astrocytes prior to transplantation provides a much greater functional recovery than transplantation of precursor cells themselves.

Subretinal transplantation of MACS purified photoreceptor precursor cells into the adult mouse retina.