Sentences with phrase «precursor lesions»
The phrase "precursor lesions" refers to abnormal changes or abnormalities in cells or tissues that have the potential to develop into a more serious condition, such as cancer. It is like an early warning sign or a pre-stage before a disease fully develops. Full definition
If a woman is positive for HPV genotypes 16 or 18, which convey the greatest risk of developing cervical cancer precursor lesions in the next three years, she should be referred for a colposcopy (an illuminated, magnified examination of the cervix and other genital tissue for premalignant or malignant lesions).
sciencedaily.com
There is no need to screen more frequently than every three years, since the cumulative occurrence of a cervical cancer precursor lesion called a CIN3 + during the three years after a negative HPV test was less than 1 percent.
In 1983, the scientists identified HPV 16 in precursor lesions of genital cancer, and in 1985, they revealed the genetic organization of HPV DNA in cervical cancer cells and the active transcription of HPV in the same kind of cells.
Additional studies in larger cohorts will be needed to validate these findings, and more biomarkers will be needed to get the completely accurate set needed to screen the general population with the long term goal of identifying precursor lesions before they become malignant.
They then conducted pathology tests on mouse pancreas tissue to determine how many PanIN precursor lesions had developed.
«IPMNs are established precursor lesions to pancreatic cancer that account for approximately half of all asymptomatic pancreatic cysts incidentally detected by computerized tomography (CT) scans or magnetic resonance imaging (MRI) in the U.S. each year.»
Moscat, an authority on p62 and cancer, explains that impaired autophagy can lead to a build up of p62 / SQSTM1, helping precursor lesions advance to full - blown pancreatic cancer through specific molecular steps.
IPMN is one of three classes of pancreatic cancer precursor lesions.
• Women who have a negative HPV test result from their primary screening have a greater reassurance of a very low risk for a future cervical cancer precursor lesion, as compared to women who have a negative Pap smear test in their primary screening.
But precursor lesions that form in the pancreas and its ducts can signal the disease before it strikes, and when caught early enough, they can be prevented from progressing to become cancer.
In a new study, researchers led by a molecular biologist at the University of California, San Francisco (UCSF), report two breakthroughs in understanding those lesions and their role in pancreatic cancer: the development of the first mouse model that simulates a precursor lesion called intraductal papillary mucinous neoplasia (IPMN), and the identification of an enzyme, Brg1, that appears to help cause the formation of IPMN lesions while also suppressing another precursor lesion.
is a translational program whose goal is to integrate prevention, screening, early diagnosis and effective treatment of oral cancer and its precursor lesions into a province - wide seamless network.
KEYWORDS: Ovarian cancer, Genomics / Epigenomics of precursor lesions, Cyclin E, Replication Stress, BRCA1 / 2, DNA Repair, Protein complexes, Biomarkers, Animal models.