Sentences with phrase «precursor protein mice»
Aged mutant amyloid precursor protein mice with established disease showed a near complete restoration in levels of synaptic and neuronal proteins after exposure to young blood in parabiosis (synaptophysin P =.02; calbindin P =.02) or following intravenous plasma administration (synaptophysin P <.001; calbindin P =.14).
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The engineered mice contained heightened quantities of RNA, the precursor of protein synthesis, for the cytokines interleukin - 1 beta and tumor necrosis factor alpha.
That's because the boosted mice produced normal — rather than high — levels of the amyloid precursor proteins from which plaques are made.
In the current study, a collaborative team of researchers at the Gladstone Institute and the Baylor College of Medicine in Houston, created a strain of mice that overproduces a precursor of Aβ known as amyloid precursor protein.
Human amyloid precursor protein (hAPP) transgenic mice from line J20, which carry mutations that cause early - onset AD (7), show major deficits in this assay (8).
Synaptotrophic defects in mouse brains lacking amyloid precursor protein (APP) expression can be selectively rescued by the non ‐ amyloidogenic APPsα fragment, for which α7 ‐ nAChRs may constitute a physiological receptor.
The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein (App) gene and contains the HSA21 - homologous genes from App to the telomere.
There exist several dozen lines of transgenic mice that express human amyloid - β protein precursor (AβPP) with Alzheimer's disease (AD)- linked mutations.
Keywords: Alzheimer's disease, amyloid plaque, amyloid - β protein precursor, plaque burden, plaque size, Thioflavin S, transgenic mouse
By Day 42, immunized animals generated plasma Abeta antibodies that labeled Abeta plaques in human, AD transgenic mouse and vervet brains; bound Abeta1 - 7; and recognized monomeric and oligomeric Abeta but not full - length amyloid precursor protein nor its C - terminal fragments.