Scientists are forced either to experiment on whole animals, which is expensive, raises ethical issues and may not
predict effects in humans, or to perform tests on microscopic human cells found in tissue cultures, which have been altered to live forever and bear little relation to actual living, breathing people.
This is not only because tests on laboratory animals can cause much suffering, but also because the relevance of the data they provide for
predicting effects in humans or other animals is severely limited by differences among major species.
Not exact matches
But when asked by Sen. Bob Corker (R - TN) if
human activity has contributed to climate change, Tillerson said that «the increase
in the greenhouse gas concentrations
in the atmosphere are having an
effect,» and that «our ability to
predict that
effect is very limited.»
«This study brings into sharp focus the
effects on wheat — one of the largest sources of nutrients for
humans,» says Irakli Loladze of the University of Nebraska
in Lincoln, who
predicted the negative
effects of rising CO2 on micronutrients seven years ago.
In contrast, Kaminski says there was no sign of a «dinner table
effect», «which would
predict that dogs try and look super-cute when they want something from the
humans.»
The findings, if found to hold true
in humans, suggest it may be possible to develop a biological marker to
predict sensitivity to radiation's
effects on the
human brain before deployment to deep space.
Studies
in the 1960s and 1970s showed that rats and
humans who can't
predict a negative
effect (such as a small shock) end up more frazzled than those who can
predict when a zap is coming.
When RNAi therapies weren't delivered to the right tissues, dangerous side
effects showed up
in humans that weren't
predicted through animal models.
«Our work highlights the fact that we need to test the
effects of potential endocrine disrupting chemicals
in both rat and
human cells to be able to accurately
predict the risk,» said Professor Habert.
Consequently,
in the past 20 years his research has evolved from an early focus on prioritizing the
effects that
humans have on coral reefs and the role that marine protected areas play
in conserving biological diversity and ecological processes, to developing theoretical and simulation models of coral reefs that will help
predict and suggest alternatives to reduce detrimental
effects, to developing practical means to restore degraded reefs through manipulation of the food web and management.
Very importantly, DDI types
predicted by DeepDDI are generated
in the form of
human - readable sentences as outputs, which describe changes
in pharmacological
effects and / or the risk of ADEs as a result of the interaction between two drugs
in pair.
The bottom line, according to a group of experts not involved
in any of these studies: Scientists don't know much about how sunlight interacts with our planet, and until they understand it, they can't accurately
predict any possible
effects of
human activity on climate change.
Thus, the data from extensive
in vivo studies
in human subjects show that low - energy sweeteners do not have any of the adverse
effects predicted by
in vitro,
in situ or knockout studies
in animals.
Following on from the 2014 Extinction Marathon which presented environmental and
human crises facing the world today (co-curated with Gustav Metzger) and the 2015 Transformation Marathon, which proposed ways of identifying and
effecting change
in the face of increasing complexity, the 2016 Miracle Marathon focused
in on ritual, repetition and magical thinking to consider ways
in which the imaginary can not only
predict, but also play a part
in affecting long - term futures.
Humans don't just have to worry about the greenhouse - emissions impacts that get nearly all of the attention, such as the hotly debated and hard - to -
predict effects on hurricane activity
in the United States.
Elsewhere
in this thread, I have
predicted that Kevin Trenberth will not focus on the definition of a null hypothesis, but will instead cite climate data as evidence that it is wiser to assume significant
human effects, unless proven otherwise, than to assume the lack of these
effects.
* * * The evidence to support the theory of anthropogenic, or
human - caused, climate change has been mounting since the mid-1950s, when atmospheric models
predicted that growing levels of CO2
in the atmosphere would add to the natural «greenhouse
effect» and lead to warming.
Ocean acidification will fry fish populations directly, too, though scientists aren't yet sure how to
predict the
effects on the stuff we haul out of the ocean to eat; they do know that
in acid waters, oysters and mussels will struggle to grow their shells, and that when the pH of
human blood drops as much as the oceans» pH has over the past generation, it induces seizures, comas, and sudden death.
The claim that «we can not
predict next month's weather
in London, so how
in the world can we
predict the
effect of
human - made greenhouse gases
in 50 years!»
The model will be used to
predict both the monthly and the cumulative
effects of
human activity
in the region - all agriculture, transportation, energy, and industry - related decisions - over the next 20 years.
The Drosophila foraging gene
human orthologue PRKG1
predicts individual differences
in the
effects of early adversity on maternal sensitivity.