Sentences with phrase «predict gene function»

This makes them ideal to predict gene function, by transferring known functional annotations from orthologs in model organisms.

Not exact matches

«To address this problem, our lab has developed new methods to predict gene and protein functions.»

The alteration is predicted to result in the production of a shortened ETV6 protein that can not fulfill its normal function of binding to DNA and regulating the expression of other genes.

They looked at whether a chemical change (methylation) in the function of the SKA2 gene measured in blood predicted the thickness of brain cortex (a measure of neuronal health) and psychological symptoms, specifically PTSD and depression.

The researchers predicted that if they removed this viral DNA from the cell, the transcription factors would not function properly, potentially disrupting genes involved in the innate immune response.

With additional information on the functions of these genes, «one could predict a risk of relapse metastasis disease showing up years later and the site at which it would come back,» says Massagué.

They then used the model to predict how autism - linked variants in the NHE9 gene would affect the protein's shape and function.

The gene function clustering in GeneMania was predicted by using the Gaussian field label propagation algorithm.

Through systematic annotation of the resulting movies, we developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling us to predict new functions for previously uncharacterized genes.

His group analyzed the sequence and predicted functions for 3,475 genes.

Genetic testing also can reveal many that have unknown consequences for the function of these genes, so their influence on cancer risk can't be predicted.

Integrating this new information into computational models, my colleagues and I predicted that about 5 percent of HARs function as noncoding RNAs, while most are enhancers that control gene expression during embryonic development.9

Our analysis predicts that the latter participate in the same biological processes as the known genes in the corresponding clusters — thus providing a starting point to study the function of poorly characterized transcripts.

By determining the function of genes on a mouse chromosome, extrapolation leads to predicting function on a human chromosome.

CONCLUSIONS: Early - onset antisocial behavior in a high - risk clinical group is predicted by a specific COMT gene variant previously linked with prefrontal cortical function and birth weight, and those possessing the val / val genotype are more susceptible to the adverse effects of prenatal risk as indexed by lower birth weight.