Sentences with phrase «predicted gene number»

With the substantial increase in predicted gene number and gene quality obtained with the OGSv2 gene set, it is clear that an updated annotation of infection responsive genes would be valuable.

Not exact matches

Standard forms of CRISPR gene drives, as the tools are called, can make tweaked DNA race through a population so easily that a small number of stray animals or plants could spread it to new territory, predicts a...

Standard forms of CRISPR gene drives, as the tools are called, can make tweaked DNA race through a population so easily that a small number of stray animals or plants could spread it to new territory, predicts a computer simulation released November 16 at bioRxiv.org.

That's several times the number of genes predicted by classical genetics experiments.

Using postmortem human brain samples, the researchers found that variations in the number of copies of the C4 gene that people had, and the length of their gene, could predict how active the gene was in the brain.

Laws of population genetics predict that, on a purely theoretical ground, such a high number of genes should translate into an extremely elevated frequency of unaffected carriers of mutations.

They removed all variants from dbSNP 129, but when they limited the scope to only mutations predicted to be «damaging» or «deleterious», the number of genes dropped to zero.

We then compiled a list of 881 predicted mRNA targets that unambiguously mapped to unique Entrez Gene IDs, and performed a number of enrichment analyses using the WebGestalt platform [21] to identify functional categories and pathways overrepresented in this gene lGene IDs, and performed a number of enrichment analyses using the WebGestalt platform [21] to identify functional categories and pathways overrepresented in this gene lgene list.

Over the next decade, he authored key papers predicting the number of genetic markers required for GWAS in humans, and pioneered the field of genetics of global gene expression (eQTL analysis).

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.