Sentences with phrase «predictive biomarkers in»

Other areas of research include designing novel therapies based on molecular pathways and identifying predictive biomarkers in patients to design personalized, targeted therapies.

Not exact matches

Adding two blood - borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Institute.

The team's next avenue of research will be focused on identifying a «biomarker» that can identify this distinct suppressive cell elsewhere in the body — for example, in blood or other samples — as a potential predictive clinical tool to determine when these cells are present in patients, which currently can not be done.

«The LSC17 score is the most powerful predictive and prognostic biomarker currently available for AML, and is the first stem cell - based biomarker developed in this way for any human cancer,» says Dr. Wang.

Predictive biomarkers of response are becoming increasingly important in the development of effective clinical trials of targeted therapies.»

In efforts to enhance pre-clinical drug testing, Thomas Gaddy of the University of Southern California, Los Angeles, and colleagues in the research group of Professor Stacey Finley investigated a potential predictive biomarker for a type of cancer drug known as anti-angiogenic therapIn efforts to enhance pre-clinical drug testing, Thomas Gaddy of the University of Southern California, Los Angeles, and colleagues in the research group of Professor Stacey Finley investigated a potential predictive biomarker for a type of cancer drug known as anti-angiogenic therapin the research group of Professor Stacey Finley investigated a potential predictive biomarker for a type of cancer drug known as anti-angiogenic therapy.

In Europe, the legislation for marketing of medicinal products (MP) and IVDs including predictive biomarker - based assays (Companion Diagnostics, CDx) are not directly linked which is challenging for co-development.

The overall goal of this study is to improve knowledge of the mechanism of HPV carcinogenesis and discover potential biomarkers in the vaginal microbiome predictive or protective of persistent HPV infection through interrogation of vaginal microbiota in a well phenotyped, homogenous cohort of Asian women.

BPRC is also involved in the development of assays and biomarkers for the predictive value of animal models in vaccine evaluation.

[30, 31] In developing candidate predictive biomarkers, several issues will make validation and adoption challenging in RCC since we may not know which tissue type (primary or metastatic tissue) to test and how many biopsy cores are needeIn developing candidate predictive biomarkers, several issues will make validation and adoption challenging in RCC since we may not know which tissue type (primary or metastatic tissue) to test and how many biopsy cores are needein RCC since we may not know which tissue type (primary or metastatic tissue) to test and how many biopsy cores are needed.

Sexual dimorphism is also evident in the expression and the predictive value of some fat - related biomarkers (16, 41, 42).

«In the preplanned biomarker analysis, the expression of pSTAT3 detected by immunohistochemistry was both a prognostic marker and a predictive biomarker of benefit from napabucasin,» the researchers wrote.

There are in fact fewer predictive biomarkers actually being used in practice in 2017, than hoped.

Christina's research leverages genome - scale data, coupled with computational modeling and iterative experimentation in order to define the molecular determinants and dynamics of tumor progression and to develop predictive and prognostic biomarkers.

As ER - α is considered a reliable biomarker in immunohistochemical analyses and is already used to guide endocrine treatment it would be a suitable treatment predictive marker for antiangiogenic therapies.

In addition, they integrate their research objectives with those of the Biomarker Sciences Program committees to incorporate predictive / prognostic molecular and imaging biomarkers into therapeutic trials, whenever possible.

In humans, the MC - specific product, chymase, is a predictive biomarker distinguishing dengue fever (DF) and dengue hemorrhagic fever (DHF).

Our approach to achieving this goal focuses on three objectives: (1) to develop a reliable, predictive panel of biomarkers (including both biological and bio-behavioral measures) that can identify children, youth, and parents showing evidence of toxic stress, and that can be collected in pediatric primary care settings; (2) to conduct basic, animal and human research on critical periods in development and individual differences in stress susceptibility, thereby informing the timing and design of a suite of new interventions that address the roots of stress - related diseases early in the life cycle; and (3) to build a strong, community - based infrastructure through which scientists, practitioners, parents, and community leaders can apply new scientific insights and innovative measures to the development of more effective interventions in the first three postnatal years.

Significant improvements in patient care will require identification of new biomarkers that are predictive of clinical behavior.

Batteries of biomarkers that measure allostatic load (also termed allostatic overload to highlight pathophysiology of the extreme)(38) tap into the major mediators of allostasis along with some key secondary outcomes, such as body mass index or waist — hip ratio and glycosylated hemoglobin (39), and provide a broad - based assessment of the dysregulation of these adaptive systems that has turned out to have predictive value in a variety of epidemiologic studies (40).

Molecular biomarkers predictive of sertraline treatment response in young children with fragile X syndrome.