Sentences with phrase «predispose patients»

«We're gaining some sense of confidence that there are a certain number of genes that, if adversely affected, predispose patients toward having this problem and possibly not healing well,» Koltun said.

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criteria

A high concentration of bile acids, as seen with a diet high in fat or with excess bile acid reflux into the gastric lumen, is thought to predispose patients to gastric cancer via promotion of gastric mucosal injury.

If, say, an unexpected adverse event pops up in a human trial, the informaticians can then sift animal, lab, and human data to investigate the possibility that certain gene variants or other factors predispose patients to the adverse event.

Some forms of EB can be lethal in infancy, and some predispose patients to an aggressive and deadly skin cancer.

Some Mendelian disorders are known to predispose patients to certain complex diseases, but these co-occurrences have thus far only been studied on a small - scale basis.

«This study may serve as a starting point for future research on how other inflammatory diseases may predispose patients for increased metastasis.»

These findings could include genetic variants that would predispose patients and their family to a variety of conditions including other cancers, Alzheimer's, and cardiovascular disease.

«Acute repeated spikes in blood sugar that you see with each dose of this drug have long - term impacts — and can predispose patients to the development of insulin - resistance Type 2 diabetes and cardiovascular disease,» said David Wright, associate professor in the Department of Human Health and Nutritional Sciences and corresponding author of the paper.

It is characterised by inflammation and scaling of the skin, accompanied by a greater risk of contracting some type of metabolic syndrome, predisposing patients to pathologies, such as obesity, diabetes or cardiovascular diseases.

Researchers found that the one - month duration HRT, was associated with a significant improvement in recurrence compared to the two - month duration CRT and therefore would be reasonable to consider in men with intermediate risk prostate cancer and who do not have risk factors that could predispose the patient to bladder side effects several years after the treatment is complete.

«We speculate that, despite the heterogeneity of patients and delirium, common mechanisms are shared by all patients developing postoperative delirium and that a pre-inflammatory state as reflected by slightly increased levels of CRP even before surgery predisposes patients to a more pronounced inflammatory response upon surgery that increases the likelihood of delirium,» said Libermann.

«What happens is the genetic defect predisposes patients to infections that drive the production of mucus that then blocks the airways and makes it difficult to breath.»

The researchers did not identify any cardiac - specific or cancer - specific features that predisposed patients to these adverse events.

This rare genetic disorder predisposes patients to increased risks for multiple kinds of cancers as well as neurodevelopmental disorders such as autism.

Moreover, intestinal permeability, as assessed by a lactulose - mannitol test, may predispose a patient to the development of food reactions, as increased intestinal permeability is associated with food allergy (Laudat et al., 1994; Andre, 1986).

If the cholesterol and triglycerides are too high, then the patient is returned to the primary care DVM with the aim of reducing the lipids preoperatively as their elevation can predispose the patient to lipemic aqueous syndrome (LAS) which can irreversibly damage an otherwise successful postoperative outcome.

If recurrent, severe FHV - 1 induced disease develops frequently in a cat, then laboratory testing to rule in or rule out various diseases that may decrease a cat's immune competence and as such predispose the patient to frequent recurrences should be considered (e.g., FeLV, FIV, FIP etc).

MPL also predisposes the patient to have a rupture of the cranial cruciate ligament.

Some dogs and cats have both cranial cruciate ligament rupture and patella luxation; in fact having one condition may predispose the patient to developing the other.

Accordingly, partnering with a board - certified veterinary dermatologist may be uniquely helpful to identify an underlying issue that predisposes a patient to anal sac impaction.

Not exact matches

This is especially critical since Andrew Lansley has rightfully placed patient health outcomes at the heart of Government reforms; a pressing imperative given rising public health challenges and an aging population predisposed to long - term conditions (LTCs).

In 1999, a study showed that the toxin can reduce migraines by as much as 50 percent among patients predisposed to them.

Given the brevity of the revised Obsessive Beliefs Questionnaire — and its potential for patients — it could become a useful tool for research as well as treatment of patients and intervention for those who are predisposed toward a number of mental health disorders, Fergus said.

Dr Falsini said elderly patients may be at higher risk because they usually have pre-existing issues that can predispose to delirium such as dementia, visual and hearing impairments, depression, use of psychoactive drugs, infections, or electrolyte disturbances.

Surgical patients given large amounts of the opioid remifentanil have shown signs of hyperalgesia; they have larger areas of soreness around their wounds and seem predisposed to chronic pain following surgery.

The authors anticipate that health care providers will use the early - detection biomarkers to test for their presence and levels in blood from pancreatic cancer patients and blood drawn from individuals with a high risk of developing pancreatic cancer, including those who have a first - degree relative with pancreatic cancer, are genetically predisposed to the disease, or who had a sudden onset of diabetes after the age of 50.

When the researchers transferred gut microbes from the twins into mice predisposed to develop a disease similar to MS, they found that after 12 weeks, three times as many mice receiving bacteria from MS patients developed brain inflammation as those receiving microbes from healthy donors.

Genetic tests could one day indicate if patients are predisposed to high levels of TNF — possibly associated with the newly identified receptor gene variant — helping to identify patients that will respond to antibody therapy.

«As opposed to the normal process of gradually linking up different centers in the brain after a stimulus, chronic pain patients have conditions that predispose them to linking up in an abrupt, explosive manner,» says first author UnCheol Lee, Ph.D., a physicist and assistant professor of anesthesiology at Michigan Medicine.

And for researchers studying the organ, new questions are emerging about how the environment, lifestyle or genetics of this small cohort of patients might predispose them to appendicitis even as it becomes less common.

In patient - derived stem cells carrying a mutation predisposing them to frontotemporal dementia, which accounts for about half of dementia cases before the age of 60, the scientists found a targetable defect that prevents normal neurodevelopment.

In experiments with cancer cell lines, the PIM1 inhibitors killed cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regression.

Yet despite achieving some encouraging results in animal models of MS, drugs that block the activity of TNF tend not work in patients with MS.. In fact, they usually make symptoms worse, and they may even have caused the disease in people predisposed to it, says Fugger.

«Although obesity and alcohol use predispose a person to acid reflux requiring antacid medication, many patients with chronic liver disease take gastric acid suppressive medications without appropriate indication.

The scientists are assembling a bank of thousands of DNA samples from patients and other people whose DNA could be informative — such as elderly individuals who carry predisposing mutations but show no sign of the disease.

«This finding might be due to the fact that those patients lived longer; given their mean age of 70 years, perhaps these patients were predisposed to more cardiac events.»

Last month, a new study found that roughly 70 percent of women who carry cancer - predisposing mutations in the genes BRCA1 and BRCA2 (the main genes included in genetic tests for breast cancer patients) will develop breast cancer, often in early adulthood.

In the next decade, molecular research is going to further develop along five lines: predictive medicine, that investigates the genetic conditions predisposing to tumor risk; early molecular diagnosis; the evaluation of each patient's prognosis based on his / her genetic profile, in other words, the analysis of what kind of mutation affects the DNA of altered cells; the investigation of the individual response to drugs, based on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed cells.»

Secondly, it would be valuable if physicians knew which patients that are predisposed to getting adverse reactions already when prescribing drugs.

While thoughts, beliefs, and feelings that originate in the mind can trigger stress responses in the body that deactivate the body's natural self - healing processes, predisposing the body to illness, the presence of illness does not mean that you've been a bad patient with bad thoughts and you deserve a cosmic spanking.

Patients with a positive glucose breath test and predisposing conditions to SIBO entered into the study, and were randomized to receive rifaximin 1200 mg / day or rifaximin 1200 mg / day plus partially hydrolysed guar gum 5 g / day for 10 days.

Fueled by a passion to determine what really makes people healthy and what really predisposes them to illness, she dug into the medical literature to study how doctors might better care for patients and patients might better care for themselves.

A proprietary nutrient formula containing 36 separate constituents, including chelated minerals, vitamins, and trace elements, may reduce symptoms of mania, depressed mood, and psychosis in bipolar patients when taken alone or used as an adjunct to conventional mood - stabilizing medications.35 - 39 Beneficial clinical outcomes in bipolar disorder may result from correction of hereditary metabolic errors in genetically predisposed individuals when select micronutrients are deficient or absent in the diet.37

Oral allergy syndrome occurs in patients with a history of atopy, and it is thus an important phenomenon to recognize in these predisposed individuals.6, 10,11

As is often the case, immunocompromised patients are predisposed, so if your cat has a condition that weakens her immune system, she's at higher risk.

This condition can be very uncomfortable for the patient, predispose them to corneal ulcerations as well as corneal damage, and cause impaired vision.

Information on a patient's eating habits may reveal early dental disease.1 Rabbits without sufficient roughage in their diet may not be grinding their teeth properly, predisposing them to overgrown teeth and dental disease.1

If testing shows the patient is still predisposed to stone formation, it is necessary to proceed down this list until control is achieved.

Part of the canine pyoderma diagnostic process will be to determine if the patient has any predisposing factors that allowed the pyoderma to take hold.