For prevention studies, they injected mouse α - syn synthetic
preformed fibrils into wild - type, normal mice, as a control, and then immediately treated the mice with Syn303, one of the MAbs used (or IgG, another type of common antibody, for the control mice).
(10) The company's scientists also report that when they then injected
preformed AS
fibrils into the brains of mice, BIIB054 slowed the self - templating spread of AS pathology across the brain (consistent with their cell - culture study), and held much of the ensuing motor dysfunction at bay (9,10)(reducing it «by more than 50 percent» according to a science journalist who was present when they presented results at AD / PD 2017 (11)-RRB-.