(6) Following this initial test of abrogating the early,
age - related rise in p16Ink4a - expressing cell burden, the investigators probed the effects of leaving BubR1H / H; INK - ATTAC to undergo 5 months of rapid «
premature aging» (and thus, to the attendant accumulation of high levels of p16Ink4a - positive cells and onset of «early -
aging»
phenotypes), and only then inducing ablation of senescent cells with the INK - ATTAC drug - activated system (see Figure 2 (g) below).