Sentences with phrase «prespecified subgroup analysis»
If we identified substantial heterogeneity (above 30 %), we planned to explore it by prespecified subgroup analysis.
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intact perineum (average RR 1.04, 95 % CI 0.95 to 1.13; participants = 13,186; studies = 10)(Analysis 1.5); There was moderate heterogeneity for this outcome (Heterogeneity: Tau ² = 0.01; I ² = 54 %), and this could not be attributed to differences in the prespecified subgroups (see below and Analysis 2.5 and Analysis 3.5).
There were similar results across prespecified subgroups of patients including analyses of PD - L1 expression, which showed hazard ratios in favor of nivolumab.
Graphical depiction of cumulative mortality in full MCE cohort (n = 9423) and prespecified subgroups in 1981 Broste thesis (Broste S. Lifetable Analysis of the Minnesota Coronary Survey.University of Minnesota, 1981.)
Specifically, the paper considers: why and how subgroup findings are important for applied research, the importance of prespecifying subgroups before analyses are conducted, and the importance of using existing theory and prior research to distinguish between subgroups for which study findings are confirmatory, as opposed to exploratory.