Amino acid profiles in term and
preterm human milk through lactation: a systematic review.
Studies comparing human milk from preterm mothers with that from term mothers suggest that these immunologic benefits may be even greater for preterm infants because secretory immunoglobulin A (IgA), lysozyme, lactoferrin, and interferon are found in greater concentrations in
preterm human milk compared with term milk.2 — 4 Very low birth weight (VLBW) infants do not benefit from the transplacental transfer of maternal immunoglobulins that occurs primarily after 34 weeks of gestation.5 These infants are exposed to abundant pathogenic organisms during neonatal intensive care unit (NICU) hospitalization and may benefit from the host defense factors present in
preterm human milk.6 — 9
Not exact matches
In March, the American Academy of Pediatrics — citing studies that showed that premature babies fed solely with breast milk have 77 percent reduced rate of NEC — stated unequivocally that all
preterm infants should receive
human breast milk.
Very - low - birth - weight infants who can not be fed mother's own milk or donor
human milk should be given
preterm infant formula if they fail to gain weight despite adequate feeding with standard infant formula.
Endogenous
Human Milk Peptide Release Is Greater after
Preterm Birth than Term Birth.
Nutritional composition of
human milk and
preterm formula for the premature infant.
G. Putet et al., «Nutrient balance, energy utilization, and composition of weight gain in very - low - birth - weight infants fed pooled
human milk or a
preterm formula,» J Pediatr 105, no. 1 (Jul 1984): 79 — 85.
One of the three major classes of immunoglobulin occurring in
human colostrum and milk, secretory IgA, has been found in significantly higher concentrations in the milk of mothers of
preterm infants compared with milk from mothers of term infants.3Skin - to - skin contact between mothers and
preterm infants in this sample may have promoted maternal production of protective antibodies specific to the nosocomial flora of the NICU.9 The provision of
human milk may enable
preterm, VLBW infants to compensate for their inherently immature immune status.
S.J. Gross, «Growth and biochemical response of
preterm infants fed
human milk or modified infant formula,» N Engl J Med 308, no. 5 (Feb 3 1983): 237 — 41.
A. Lucas et al., «A randomised multicentre study of
human milk versus formula and later development in
preterm infants,» Arch Dis Child Fetal Neonatal Ed (England) 70, no. 2 (Mar 1994): F141 — 6.
A. Lucas et al., «Randomized outcome trial of
human milk fortification and developmental outcome in
preterm infants,» Am J Clin Nutr (England) 64, no. 2 (Aug 1996): 142 — 51.
R.J. Schanler et al., «Bone mineralization outcomes in
human milk - fed
preterm infants,» Pediatr Res 31, no. 6 (Jun 1992): 583 — 6.
S.J. Gross, «Bone mineralization in
preterm infants fed
human milk with and without mineral supplementation,» J Pediatr 111, no. 3 (Sep 1987): 450 — 8.
It would also be great if you could explain why medical associations such as ESPGHAN recommend
human milk fortification for
preterm infants if that was so unnecesary as you state in your book.
Schanler R.J., Lau, C., Hurst, N.M., & Smith, E.O. Randomized trial of donor
human milk versus
preterm formula as substitutes for mothers» own milk in the feeding of extremely premature infants.
Although multi-functional, other proteins in
human milk, including secretory IgA, lactoferrin and lysozyme — and macrophages and free fatty acids — act as anti-infective agents, which are essential for the
preterm infant.
For
preterm infants,
human milk feeding, in particular the woman's own milk, is associated with a reduced risk of necrotizing enterocolitis (18) and other infectious morbidity.
This overview of Medela's NICU feeding solutions is an entry point to more detailed materials and initiatives dedicated to
human milk and to breastfeeding
preterm infants.
Effect of Added Calcium, Phosphorus, and Infant Formula on Calcium and Phosphorus Dialyzability in
Preterm Donor
Human Milk
The abundant proteins in
human milk have been well characterized and are known to provide nutritional, protective, and developmental advantages to both term and
preterm...
Medela helps NICU professionals find the optimal solution for each situation while feeding
human milk to
preterms.
The 2012 policy on
human milk and breastfeeding issued by the American Academy of Pediatrics states that they recommend the use of
human milk for all
preterm infants, whether mother's milk or pasteurized donor milk, when mother's milk is unavailable.
Additionally, a Johns Hopkins Children's Center study recently showed that extremely premature babies fed
human donor milk are less likely to develop NEC, than babies fed a standard premature formula (often referred to as
preterm infant formula) derived from cow's milk.
The study was the first of its kind to compare the risk of developing NEC and requiring NEC surgery among premature infants on an exclusively
human milk diet versus those fed
preterm infant formula derived from cow's milk (http://www.hopkinschildrens.org/
Human-Donor-Milk-Lower-Risk-for-Premature-Babies.aspx).
This presentation aims to focus mainly on the benefits deriving from the use of donor
human milk in feeding
preterm infants:
Human milk from mothers who delivered
preterm has a higher nutrient content during the first weeks of lactation.
While NEC continues to be a significant cause of mortality and morbidity in extreme
preterm infants, the increased use of
human breast milk and implementation of standardized feeding protocols have helped to reduce its incidence.
A major field of research is
human milk for
preterm infants: measurement of its composition, optimization of the fortification, best way to pasteurize
human milk to preserve its quality.
The aim of the present organization is to provide most
preterm infants with pasteurized donor
human milk when mother's milk is not available.
The third and last part of the presentation will be dedicated to the proven beneficial effects of donor
human milk on health outcomes in
preterm infants.
The guidelines should also lay down clearly the order in which infants may receive milk from
human milk banks to ensure that newborns who are critically ill or
preterm babies are on top of the list.
To compare the immune proteome of breast milk from term and
preterm mothers, since a majority of milk donated to the Dutch
Human Milk Bank comes from term mothers, and to determine the effect of pasteurization.
Human cytomegalovirus reactivation during lactation and mother - to - child transmission in
preterm infants.
In addition,
human milk - fed premature infants receive significant benefits with respect to host protection and improved developmental outcomes compared with formula - fed premature infants.13 — 22 From studies in
preterm and term infants, the following outcomes have been documented.
infants, there is insufficient mother's milk, and a supplement of pasteurized donor
human milk (donor milk) or
preterm formula is required.
The name «
human milk fortifiers» was certainly given in attempt to set them apart from the negative study findings associated with
preterm formulas.
[Teens born prematurely had less atherosclerosis if fed donor
human milk rather than
preterm formula.]
In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In
human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in
preterm infants, 32 decreases heart rate variability in
preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.
Feeding premature infants with
human milk or
preterm milk formula.
It follows that to feed most
preterm, sick or low birthweight infants with
human milk, some system of
human milk banking needs to be set up.
This type of inflammation between 18 and 32 weeks of gestation in
humans has been linked to
preterm birth as well as an imbalance of immune cells in the brain of the offspring and even death of nerve cells in the brains of those children.
Both the KUDOS (Kansas DHA Outcome Study), directed by Carlson and Colombo, and the DOMinO (DHA to Optimize Mother Infant Outcome) study directed by Maria Makrides, professor of
human nutrition and Healthy Mothers, Babies and Children theme leader for the South Australian Health & Medical Research Institute, and Robert Gibson, professor of functional food science at the University of Adelaide, saw a small overall increase in gestation length, but this increase was found to be related to a decrease in deliveries at higher risk for early
preterm birth.
«In
human infants, this includes the third trimester, when many
preterm infants spend time in a neonatal intensive care unit.
A 2011 statement released by the National Institute of Child Health and
Human Development (NICHD) indicated that available evidence did not support the routine use of iNO in
preterm neonates and discouraged the use of this expensive therapy in
preterm neonates.
UIC researchers, led by Barbara McFarlin, professor of nursing, have received a five - year $ 2.84 million grant from the National Institute of Child Health and
Human Development to develop techniques to accurately predict
preterm birth.
Won Soon Park, MD, PhD, and colleagues from Samsung Medical Center and Biomedical Research Institute, Seoul, Republic of Korea, conducted a phase I, single - center trial of intratracheal transplantation of
human umbilical cord blood - derived mesenchymal stem cells to nine very
preterm infants (24 - 26 weeks gestational age) who were at high risk of developing BPD.
«
Human milk feeding potentially plays a strong role in protecting very
preterm newborns from any - stage ROP and severe ROP,» the international team of study authors wrote.
The studies included more than 2,200
preterm infants, comparing how often babies had been fed
human milk or formula, and whether or not they developed ROP.
The first of its kind, a study by Greiger et al entitled Preconception Dietary Patterns in
Human Pregnancies Are Associated with
Preterm Delivery has attempted to quantify the potential negative impact of poor dietary choices before pregnancy on pregnancy outcomes.
It finds that in 2010, about 2.7 million
preterm births globally — or 18 % of all pre-term births — were associated with outdoor exposure to fine particulate matter (PM2.5 is especially harmful to
human health, as it can penetrate deep inside the lungs).