Sentences with phrase «prevent activation»

These treatments prevent the activation of many cells involved in inflammation.

Low progesterone can prevent activation of GABA, the neurotransmitter that promotes relaxation.

As mentioned above, nutrient deficiencies may prevent activation of your T4 into T3.

11β - hydroxysteroid dehydrogenase II (11β - HSD II) is found in salivary glands and aldosterone - selective tissues, e.g. kidneys, where it oxidizes cortisol to cortisone to prevent activation of the mineralocorticoid receptor.

Sprouting begins germination, which increases the enzymatic activity in foods and inactivates substances called enzyme inhibitors.1 These enzyme inhibitors prevent the activation of the enzymes present in the food and, therefore, may hinder optimal digestion and absorption.

We are currently studying viral and host 2», 5» - phosphodiesterases that prevent activation of RNase L, thus allowing virus replication and viral pathogenesis.

«Navire's compounds potently bind SHP2 and prevent activation of the protein, blocking its ability to promote tumor growth,» said Virani.

«We have found that 10 % of colon and stomach tumors present the loss of a molecule called TP53TG1, whose function in healthy cells is to prevent activation of YBX1 protein.

The drug worked in neurons incubating in a dish to prevent activation of phospholipase Cγ1 via TrkB.

In the future, the scientists plan to use this system to study the effect of these and other compounds that may prevent the activation of HIV - 1 in the brain.

«These results identify drug candidates that may prevent activation of latent viruses in astrocytes,» Schneider concluded.

If, because of extended separation, these hormones are not soothed by contact with the mother, the baby can go into psychological shock, which, according to author Joseph Chilton Pearce, will prevent the activation of specific brain functions that is nature's blueprint for this time.

A low - fat diet in combination with limited caloric consumption prevents activation of the brain's immune cells — called microglia — in aging mice, shows research published today in Frontiers in Molecular Neuroscience.

The experiments have shown that the inhibition of endosomal acidification prevents the activation of P45 - IKKα and specifically inhibits the growth of cancer cells with mutant BRAF, both in vitro and in vivo.

Whitehead Institute scientists report that the gene mutated in the rare hereditary disorder known as Birt - Hogg - Dubé cancer syndrome prevents activation of mTORC1, a critical nutrient - sensing and growth - regulating cellular pathway.

This prevents activation of genes, so this is therefore an exclusion type regulation where insulin signaling leads to prevention of gene activation by Fox01.

«By re-directing the immune responses, our vaccine not only suppresses the response but prevents the activation of cells that would initiate allergic reactions.

By inhibiting c - Src activation, α - tocotrienol also prevents activation of 12 - Lox, suppressing arachidonic acid metabolism.

The system prevented activation of the passenger airbag if a special Mercedes child seat with transponder was fitted.

Not exact matches

In a statement, Apple said that its kill switch software, Activation Lock, was aimed at preventing unauthorized access to users» iPhones and iPads.

Cell Metabolism: Activation of TRPV1 by Dietary Capsaicin Improves Endothelium - Dependent Vasorelaxation and Prevents Hypertension

Telomerase Activation Sciences, CEO claimed two products could treat or prevent a range of age - related conditions.

«Drink OR Drive» is just one of many U.S. activations, which includes the Health Alliance on Alcohol, a national public initiative to prevent underage drinking.

We have previously described studies of pacing strategy using various experimental interventions, including faster and slower starts, higher temperatures, hypoxia, hyperoxia and altered energy substrate availability.1 We have proposed the presence of a complex, regulatory system that mediates changes to skeletal muscle motor unit activation and work rate in order both to optimise performance and prevent potentially harmful changes to homeostasis.

A three second delay start in the power button helps prevent unintentional activation.

β - Arrestin 1 or β - arrestin 2 depletion prevented the localization of Smo to primary cilia and the Smo - dependent activation of Gli.

Frequent, low - dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the murine study «Metronomic chemotherapy prevents therapy - induced stromal activation and induction of tumor - initiating cells,» which will be published online November 23 in The Journal of Experimental Medicine.

Researchers at CSHL have discovered a new fail - safe mechanism that prevents transposon activation even when the inactivating marks have been erased.

Different drug molecules make it possible to affect the function of these receptors and, consequently, to prevent cell activation and mediator release.

«Caloric restriction in combination with low - fat diet helps protect aging mouse brains: Low - fat diet plus limited caloric intake prevented aging - induced inflammatory activation of microglia; exercise was significantly less effective than caloric restriction in preventing these changes.»

«Aging - induced inflammatory activation of microglia could only be prevented when mice were fed a low - fat diet in combination with limited caloric intake,» says Eggen.

«Because of the important role of UPR in regulating cell life / death decisions, it is critical that mechanisms are in place to prevent unnecessary UPR activation in response to innocuous or low - level stimuli,» said Wilkinson.

Specifically, they discovered that NMD prevents inappropriate activation of the UPR and also promotes its timely termination to protect cells from prolonged ER stress.

Extrapolating to intact airways, these results suggest OR1D2 activation would constrict the bronchi, whereas stimulating OR2AG1 might help prevent airways from closing in response to pathological triggers.

His laboratory already has shown that by inhibiting calcium channels in T - cells, they were able to prevent T - cell activation in animal models of autoimmune diseases like multiple sclerosis and colitis.

«Activation of these cell receptors appear to prevent brain cells from cleaning out the trash — the toxic buildup of proteins, such as alpha - synuclein, tau and amyloid, common in neurodegenerative diseases,» says the study's senior author, neurologist Charbel Moussa, MBBS, PhD, director of Georgetown's Laboratory for Dementia and Parkinsonism, and scientific and clinical research director of the GUMC Translational Neurotherapeutics Program.

In rheumatoid arthritis, abatacept inhibits T - cell activation and prevents the chain of events that lead to debilitating joint inflammation.

«Combination therapies using BRAF inhibitors and other inhibitors are being considered to prevent paradoxical activation of MAPK pathways.»

To test this idea, the scientists applied glutamate blockers to mixed cultures, which indeed prevented Nrf2 activation.

In a follow - on project to be conducted in collaboration with MedUni Vienna's Institute of Pharmacology and Center for Addiction Research and Science (AddRess) and, in particular, with drug and dopamine expert Harald Sitte, amongst others, the objective is now to find out whether, and, if so, how, activation of DeltaFosB can be prevented and how this highly promising starting point can be used to treat the onset of addictive behaviour.

These designer proteins bind tightly to CGRP molecules or their receptors on trigeminal nerve cells, preventing cell activation.

You may lower the load, you may even prevent disease progression and eliminate need for antiretrovirals, but you will still have chronic immune activation and the problems caused by that.»

It can take military space watchers weeks to sort out each CubeSat's orbit, he says, and failure to be able to track and identify objects can prevent operators from being able to perform key activation tasks and result in the loss of a satellite.

«While there are clearly other factors that can cause these types of abnormalities, including genetic vulnerabilities, demonstrating that immune activation alone can produce these effects offers new hope for treatments that might reduce their severity, or prevent them altogether, in certain individuals.»

Since baclofen and similar medications reduce these effects in laboratory animals, we wanted to examine whether it could prevent drug - cue induced activation in the human brain.»

In PKA, because the R - and C - subunits are in separate molecules, they diffuse away upon activation, preventing possible reassociation that may cause unnecessary inhibition.

The next step would be immunosuppressive therapy, which could slow down viral replication by limiting the T cell activation and prevent the CD4 + T cells from committing suicide.

In cell cultures and in mice LPA prevented signaling within cells, the appearance of molecules associated with T - cell activation, and proliferation of the T cells.

While this study did not lead to new drugs to prevent the suppression of Pax3 or the activation of p53, «it gives us a better understanding at the molecular level of why [certain] defects occur,» said Dr. Loeken.

Cardiac thromboxane A2 receptor activation does not directly induce cardiomyocyte hypertrophy but does cause cell death that is prevented with gentamicin and 2 - APB.