Sentences with phrase «prevent phosphorylation»

«Now, we need to better understand how this works at the molecular level so we can perhaps design therapeutics to prevent phosphorylation of that site.»

[5,7,9] Flavopiridol also inhibits cdk7 / cyclin H, thus preventing the phosphorylation and subsequent activation of several cdks [6,8] and down - regulates cyclin D1, the cyclin associated with cdks 4 and 6.

Not exact matches

In vitro, Pkn1 — / — Cgcs exhibited deregulated axonal outgrowth, elevated AKT phosphorylation, and higher levels of neuronal differentiation - 2 (NeuroD2), a transcription factor preventing presynaptic maturation.

Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.

Redundant mechanisms prevent mitotic entry following replication arrest in the absence of Cdc25 hyper - phosphorylation in fission yeast.

This activation partly occurs through, for example, phosphorylation of GSK - 3 which prevents its own inhibition of SREBP1c.

AS160 is actually a Rab GAP, and GTP is activating protein, and by phosphorylation it prevents its action.

In the yeast cells, they showed that the more effectively they prevented full aggregation — by adding more sites mimicking phosphorylation — the more robustly colonies of the cells would grow.

Hence, a potential phosphorylation event might be able to prevent formation of one of these conformations while leaving the other homodimer (as well as heterodimer formation potential) intact.

By blocking the enzyme hexokinase, it prevents glucose phosphorylation.

The E3 isoform has been proven to bind to tau (with the same suspected for E2), thus preventing or minimizing its phosphorylation.

Removing acidic processed foods, sugar, flour, high - glycemic foods, coffee, and alcohol can prevent alterations in membrane potential which compromises mitochondrial function by interfering with the electron transport chain integral to oxygen - based oxidative phosphorylation (55, 56).