Sentences with phrase «prevented graft»

In pre-clinical studies conducted by the researchers, a one - time, local injection of the hydrogel - drug combo prevented graft rejection for more than 100 days compared to 35.5 days for recipients receiving only tacrolimus and 11 days for recipients without treatment or only receiving hydrogel.

«Finding the optimal conditions to avoid interfering with immune cells working to eradicate cancer while preventing graft rejection and GVHD is the holy grail of bone marrow transplant,» says Leo Luznik, M.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center.

Results of a Johns Hopkins study may explain why a chemotherapy drug called cyclophosphamide prevents graft - versus - host (GVHD) disease in people who receive bone marrow transplants.

«Preventing graft - versus - host disease and relapse after transplant requires a difficult balance of eliminating the bad, overactive effector T cells, without suppressing the good, regulatory T cells,» said Kean, who is also an associate professor of pediatrics at the University of Washington School of Medicine and a member of the Fred Hutchinson Cancer Research Center.

«Protection for the gut barrier: New approach may prevent graft - versus - host disease: Activating signal paths could protect patients from dangerous immune reactions after stem cell transplantations.»

«This is an entirely new approach to preventing graft - vs.

But U-M researchers, led by senior study author Pavan Reddy, M.D., found in laboratory studies that the drug had anti-inflammatory effects as well — which they hypothesized could be useful in preventing graft - vs.

That's what's potentially great about using it to prevent graft - vs.

Antiviral strategies are urgently needed which target hepatitis C virus in its initial phases for preventing graft re-infection and improving long term outcomes for sufferers.

Not exact matches

«It is on record that when anti graft agencies sent invitation letters to judges suspected of corruption, they had rushed to the Federal High Court to obtain interlocutory injunctions to prevent their arrest, investigation and prosecution.

Johns Hopkins Kimmel Cancer Center scientists first used cyclophosphamide to prevent severe graft - versus - host disease (GVHD) after bone marrow transplant involving haploidentical or «half - matched» transplants, a treatment first used in 2000 at the Cancer Center to treat leukemias and other blood cancers.

Grafting skin to cover burn wounds is also important for preventing infections, which can be a source of complications.

Fay hopes that if future studies are successful, PAI - 039 or similar drugs could be used to prevent blockages in arteries and bypass grafts.

The researchers found that PAI - 039 inhibited the migration of cultured human coronary artery smooth muscle cells, and prevented the development of blockages in arteries and bypass grafts in mice.

«Inflammation is important in an injury because it helps to kill off bugs and prevent infection, but during a skin graft inflammation is a problem and can cause rejection of the new skin,» explains Dr Haycock.

Following a tissue graft transplant — such as that of the face, hand, arm or leg — it is standard for doctors to immediately give transplant recipients immunosuppressant drugs to prevent their body's immune system from rejecting and attacking the new body part.

Placement of a sheet of PTFE between the graft and surrounding structures can also help to prevent erosion.

Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft - versus - host disease (GvHD) after therapeutic bone marrow transplants.

MSC - induced Tregs were donor - specific since adoptive transfer of splenocytes from tolerant mice prevented the rejection of fully MHC - mismatched donor - specific secondary allografts but not of third - party grafts.

Low - dose donor CD8 + cells in the CD4 - depleted graft prevent allogeneic marrow graft rejection and severe graft - versus - host disease for chronic myeloid leukemia patients in first chronic phase.

Individual grafts, one - cell - thick and 1.2 to 3.2 square feet in area, were gently applied to prepared «wound beds,» where the natural bacterial residents had been removed and thread - like fibrin protein laid down, which prevents shrinkage before dissolving.

The researchers are trying to reproduce large quantities of T - regulatory cells outside of the body with the hope that by infusing more T - regulatory cells could prevent or treat graft - vs.

Scientists grafted genetically edited human skin cells to treat type - 2 diabetes and prevent obesity in mice.