Sentences with phrase «preventing cell differentiation»
Both conditions are mutually exclusive and act preventing cell differentiation and promoting cell growth.
https://www.sciencedaily.com/
Briefly, ES cells were kept in standard ES cell medium containing leukemia inhibitory factor (LIF) which prevents cell differentiation.
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Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons.
«Together,» explains Dr. Ramiro, «the results indicate that CTCF is important for maintaining the germinal center differentiation program and prevents premature differentiation towards plasma cells.»
Even though STAT3 activity drives the expansion of MDSCs and is involved in immune responses mediated by the cells, they found that high levels of STAT3 activity actually prevent the differentiation of MDSCs to macrophages.
Several studies have also suggested that OX40 signals can directly prevent suppressive activity of nTreg and can inhibit the induction of iTreg which further aid the clonal expansion and differentiation of effector T cells.
Concomitant PLK4OE and p53 deletion (PLK4OE / p53cKO) rescued the differentiation defects, but did not prevent the apoptosis of PLK4OE cells.
Yu et al. (46) used mice deficient for both T - bet and RORγt as T cell donors and showed that blockade of both Th1 and Th17 differentiation is required to prevent acute GVHD.
We show that the fraction of cells present within this state is influenced by factors that both promote and suppress primitive endoderm differentiation, but conditions that support ES cell self - renewal prevent their progression into differentiation and support an equilibrium between this state and at least one other that resembles the Nanog positive inner cell mass of the mammalian blastocysts.
Grant Title: 01759: Disrupting the Differentiation of Cancer Stem Cells to Prevent the Spread of Hemangiosarcoma