Sentences with phrase «previous treatment studies»

The Sleep Impairment Index has adequate psychometric properties and has been shown sensitive to changes in previous treatment studies of insomnia.24, 25

Not exact matches

That's striking because the treatment is part of a class called CETP medicines which haven't proven particularly successful in previous studies.

In a previous study where we explored women's preferences for aspects of intrapartum care regarding planned place of birth we reported that women with a preference for a hospital birth — both midwife - led and obstetrician - led — found the possibility of pain relief treatment much more important compared to women with a preference for a home birth [18].

Several clinical centres in the USA and Canada recruited four groups of men with CRPC to a phase II study to receive 2550 mg of galeterone orally once a day: 22 men had CRPC that had not metastasised (spread) and had received no previous treatment; 39 men had metastatic CRPC and no previous treatment with abiraterone or enzalutamide; 37 and nine men had metastatic CRPC and had failed treatment with abiraterone and enzalutamide respectively.

This recommendation comes from the Valence study where high SVR rates were seen in those who had no previous HCV treatment history, without or with scarring of the liver, known as cirrhosis (93 % and 92 %, respectively).

«Although radiosurgery has been shown to be an effective post-surgical treatment for metastatic brain tumors, previous studies did not compare patient outcomes from a single hospital over the same period of time,» said N. Scott Litofsky, M.D., chief of the Division of Neurological Surgery at the MU School of Medicine and senior author of the study.

Previous studies also demonstrate that moderate hypo - fractionated radiation therapy (HRT), consisting of daily treatment for one month using a larger dose per treatment, provides a similar low risk of recurrence, and may even be lower with HRT than CRT.

Previous studies have suggested that various forms of meditation can improve attention and reduce stress, but there have been few randomised controlled trials — the best way of testing a treatment's effectiveness.

The trial, a phase 3 study involving major cancer research institutions in Europe, the United States, Australia and Japan, enrolled 800 patients with metastatic colorectal cancer that was progressing despite previous treatment.

Previous studies suggest that certain groups prefer alternative treatments to traditional pharmacotherapy for health conditions, she said.

«Previous studies had tested the use of rosiglitazone for cancer treatment, but the outcome was not encouraging.

While previous studies have surveyed the genomic characteristics of tumors confined to the prostate gland, the new study is the first to focus on metastatic hormone resistant prostate cancers, which can be difficult to treat because they often develop resistance to standard treatments.

In a previous study more strictly focused on the intensity of emergency care treatments, Doyle also found that higher spending leads to better outcomes.

«However, we believe our study findings, in combination with the previous literature and our clinical experience, are sufficient to support catheter ablation as first - line treatment for AFL,» Marcus said.

After his team first observed hair loss in Treg - deficient mice, Rosenblum learned that the genes associated with alopecia in previous studies are almost all related to Tregs, and treatments that boost Treg function have been shown to be an effective treatment for the disease.

«This study confirms previous research findings that the refusal of patients to receive treatment and their perception of the eating disorder may change during treatment, even in cases of the patient receiving treatment against their initial will.

In a previous study, Nesha Burghardt, then a graduate student at New York University, and her colleagues demonstrated that long - term SSRI treatment impairs fear conditioning in rats.

In a study published in the Journal of Acquired Immune Deficiency Syndrome, Dr. Sean B. Rourke found that in 2011, 87.3 per cent of people in the Ontario study were receiving care (defined as having had one viral load test measuring amount of HIV virus in the blood in the previous year), 77 per cent were on antiretroviral treatment and 76 per cent had a suppressed viral load.

In addition to making a medical diagnosis, the AI platform also generated a referral and treatment recommendation not done in previous studies.

Study findings were consistent with previous research suggesting that elderly women are at high - risk for inadequate surgical treatment of cancer.

«Some previous research has suggested that treating patients with statins after they suffer hemorrhagic stroke may increase their long - term risk of continued bleeding,» said lead author Alexander Flint, MD, PhD, of the Kaiser Permanente Department of Neuroscience in Redwood City, Calif. «Yet the findings of our study suggest that stopping statin treatments for these patients may carry substantial risks.»

Previous studies showed that cognitive remediation — or training programs to reverse cognitive declines, offer potential benefits for people with MS.. But, to ensure maximum benefit, many of these programs require in - person treatment sessions in an outpatient setting multiple times a week for at least an hour.

Results from this study support previous findings that beliefs can alter a drug's effects on craving, providing insight into possible avenues for novel methods of addiction treatments.

Despite findings of previous studies and published guidelines, nearly two - thirds of patients with T4a larynx («voice box») cancer are not receiving a total laryngectomy (surgical removal of the larynx), the recommended form of treatment, and as a result, have significantly worse survival rates versus those treated with a total laryngectomy, a new study published in the International Journal of Radiation Oncology, Biology and Physics by experts at Penn Medicine found.

Previous studies have shown a benefit in adding a second antiplatelet drug like ticagrelor, from a class called P2Y12 inhibitors, but they investigated the additional therapy for only a year, leaving unanswered the question of whether patients would benefit from continuing this treatment longer.

The study adds to previous research by lead investigator Kalyani Sonawane, Ph.D., demonstrating that the drug treatment, which combines two drugs in a single pill, known as fixed - dose combination, has several advantages over other approaches for adjusting blood pressure medication.

This study contributes to our previous research by showing that early detection and treatment among individuals at high risk of type 2 diabetes has the potential to reduce costs.»

In a previous study, investigators at the Cancer Institute showed that using a vaccine treatment for bladder and breast cancer tumors in laboratory models resulted in a reversal of the traditional immune blockade, as well as the development of tumor specific immunity throughout the body.

Previous studies looking at extremely preterm infants - babies born after only 22 to 28 weeks of gestation - typically only look at short periods of time and often use data from specialized centers with the latest technology and treatments, Malloy said.

He adds, «We have shown in a previous study that mindfulness group therapy is just as effective as individual CBT for the treatment of typical depression and anxiety symptoms; something we also observed in the new study.»

No safety concerns were identified in previous studies of pemetrexed and gemcitabine for treatment in children with other cancers.

Doctors» unconscious biases favor whites but do not affect high blood pressure treatment for their minority patients, according to a University of Colorado Boulder study, even though a previous study by the same research group found that doctors» biases are reflected in lower ratings by African - American patients.

«They are gorgeous studies, but they are in mice,» he says, noting that a number of previous promising diabetes treatments that have worked in mice have failed to help human diabetics.

Previous studies show that antibody treatments that inhibit the protein, called programmed cell death 1 (PD - 1), can shrink tumors in humans.

Previous studies conducted with both military members and civilians who have experienced trauma have shown anger in the context of PTSD to be far more than a symptom; it can predict PTSD severity but also interfere with PTSD treatment.

«Despite the limitations of a single arm, non-randomized study, we infer from these data that Interferon ß - 1a treatment is worth further consideration for the treatment of Ebola virus disease,» said Dr. Fish, who is also a Professor in the Department of Immunology at the University of Toronto, noting that the decision to undertake the clinical trial was based on previous preliminary scientific data, and on the fact that no currently approved antivirals exist to treat Ebola.

Given these previous findings in relation to the BDNF pathway following J147 treatment, the effect of J147 on neurotrophic factors was investigated in this AD reversal study.

The study had begun as a comparative study of patients given Gleevec or the previous standard treatment, interferon alfa plus cytarabine.

Participants are being asked to take part in this study because they have advanced or metastatic non-small cell lung cancer that has recurred or progressed after previous chemotherapy (s) including a platinum - based treatment.

A recent phase III study revealed a benefit with pacritinib for patients with myelofibrosis and thrombocytopenia who have experienced treatment failure with previous therapies.

A new animal study involving virally - delivered gene therapies has indicated that high treatment doses might not be as safe as previous human trials have suggested

Because Akt is an important factor in the differentiation and immune function of T cells, and previous studies showed that VPA and other HDAC inhibitors could inhibit Akt activity in cancer cells (41, 42), we examined whether Akt activity was modulated by VPA treatment.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

The study looked at about 700 people in the U.K. who had sought treatment for low back pain over the previous six months.

«Previous animal and human brain imaging studies have suggested that psilocybin may have effects similar to other antidepressant treatments,» explained study senior author David Nutt, also of Imperial College London.

Previous studies suggested that treatment of diabetic patients with the antioxidant alpha - lipoic acid reduce oxidative stress and urinary albumin excretion.

Lexapro, which is in the same class of drugs as Prozac, appeared to be a promising treatment for hot flashes in previous studies, but the results were inconclusive.

In a previous postprandial study (13), each treatment was consumed in the context of a high - fat meal, which may have increased absorption and bioavailability of lipophilic nutrients.

In this study, 27 high - poverty elementary schools (75 — 100 % eligibility for free or reduced - price lunch) were matched by prior reading achievement and poverty level and randomly assigned to one of two implementation conditions: a core treatment condition that directly replicated implementation procedures used in previous experiments, or a core treatment with structured teacher adaptations condition.

Within schools, students were randomly assigned to a control condition or one of two treatment conditions: a basic treatment condition replicating procedures used in the previous studies or an enhanced treatment condition that added teacher calls in the summer.