Sentences with phrase «previously known genes»

Not exact matches

Interestingly, as many as nine of the genes have been previously associated with some vascular disease and four more are known to be involved in the regulation of vascular tone, supporting the importance of blood vessels in migraine attacks.

The less adept mice, Rubin's team found, carry extra copies of a previously known human gene called DYRK; a mutated version of an almost identical gene in fruit flies, called minibrain, causes neurological defects.

In a 2006 study published in Cell, Vidal and Huda Zoghbi, a neurobiologist at Baylor College of Medicine in Houston, Texas, teamed up to show previously unsuspected interactions among the proteins produced by mutated genes in several of the movement disorders known as ataxias.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

Over half of these genes had no previously known role, and the remaining genes were poorly understood.

Although that marker, called IL21, had not previously been associated with autoimmune diseases, the gene that produces it sits right in the stretch of DNA known to make these mice vulnerable to diabetes, suggesting that IL21 might make a drug target, says Sarvetnick.Furthermore, by giving the animals a shot of dead bacteria — similar to an immunization in humans — when they were newborns, Sarvetnick and her colleagues prevented a surfeit of CD4 + and CD8 + cells.

As an example, the current study identified and provided insight into the function of several genes, not previously known to be involved in the taste system, related to cell motility.

In a study led by Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research member Dr. Julian Martinez - Agosto, UCLA scientists have shown that two genes not previously known to be involved with the immune system play a crucial role in how progenitor stem cells are activated to fight infection.

Previously, only four genes were known to be linked to Alzheimer's, which affects an estimated 5 million Americans.

If, on the other hand, what you hear about is experiments in which previously known modules like genes are swapped around, then expect a more dismal, softwarelike biotechnology.

The two genes were previously known to cause Lynch syndrome, an inherited condition that raises the risk of colorectal, ovarian, stomach, and endometrial cancer.

Previously known mutations in the gene encoding SLC25A3 are responsible for poorly understood genetic disorders involving dysfunctional heart and muscle fibers, leading to enlarged hearts and low muscle tone.

This technique pointed out particular versions of 22 genes, half of which were not previously known to have a role in intellectual ability.

In back - to - back papers published online July 28 in Science, researchers from the Broad Institute, Dana - Farber Cancer Institute, Johns Hopkins Kimmel Cancer Center, the University of Pittsburgh, and the University of Texas MD Anderson Cancer Center have confirmed genetic abnormalities previously suspected in head and neck cancer, including defects in the tumor suppressor gene known as p53.

Abeliovich and her partner Herve Rhinn, assistant professor of clinical pathology at Columbia University, knew that TMEM106B and another gene called GRN were previously found to be associated with frontotemporal dementia, which is a rare, devastating neurodegenerative disorder.

This newly discovered gene has the same developmental role as an unrelated, previously - known gene which appears to have been lost or altered in certain fly families during evolution.

Scientists know that muscle cells turn on some genes that only work in muscle, but it has not been previously possible to examine the regulatory elements that control that process.

Importantly, for the maintenance of healthy plaque pH, gene transcription activity of known and previously unrecognized pH - neutralizing pathways was associated with the genera Lactobacillus, Veillonella and Streptococcus during the pH recovery phase.

All of the significant regions had been previously reported / validated; they included or were proximal to a number of well - known cancer genes including EGFR, CCND1, KRAS, MDM2, PDGFRA, and others.

Some of the identified genes are previously known to be involved in the development of oyster shells, but the study also presents novel gene candidates.

The human T cell receptor beta (TRB, previously known as TCRB) gene locus on chromosome 7 (7q34) includes 65 Vb (variable) gene segments, followed by two separate clusters of genes each containing a Db (diversity) gene, several Jb (joining) genes, and a Cb (constant) region spread over 685 kilobases.

We use three sources of information to update the homology - based immune catalog in Nasonia: a previously published catalog of antimicrobial peptides [35], homology to characterized Dipteran immune proteins based on reciprocal best blastp hits to D. melanogaster, and profile hidden Markov models (HMMs) of known immune - related gene families derived from ImmunoDB [11](see methods for details).

In this study, using whole - genome DNA sequencing (WGS) and confirmation by Sanger sequencing, we observed mutations identified in several genes not previously known to be recurrently altered in SMZL.

Mutations in one of these genes, NF1 — a known tumor suppressor gene that regulates the RTK / RAS / RAF pathway — had previously been reported in lung cancer.

BLASTing the 15 - bp PORE sequence revealed a large cohort of genes potentially regulated by such a mechanism (although osteopontin, the one target gene previously known to be regulated by a PORE sequence, was not identified in this analysis).

The results from this study also revealed an association between the presence of XMRV and patients known to be homozygous for the R462Q variant of RNAse L, a gene previously linked to the hereditary prostate cancer 1 locus [4].

Previously, scientists knew about only 13 genes that influenced hair color.

Of these, 126 genes were orthologous to protein - coding genes in the human genome (hereafter, human BC susceptibility genes, hBCSGs), 70 % of which are previously reported cancer - associated genes, and ∼ 16 % are known BC suppressor genes.

«Although we knew that the EAAT2 gene has a crucial role to play in neurological processes in human and potentially in the development of migraine, until now, no genetic link has been identified to suggest that glutamate accumulation in the brain could play a role in common migraine,» says co-senior author of the study Professor Christian Kubisch of University of Ulm, Germany (previously at the University of Cologne where he conducted his research for this study.)

Sharp's screenplays are marked by a narrative complexity and situations gravid with implication and doom.1 Take the moment in the Arthur Penn - helmed Night Moves where broken - down P.I. Harry Moseby (Gene Hackman, reuniting with Penn for the first time since Bonnie and Clyde), after discovering a body in a sunken wreck off the coast of Florida, watches as his two sleazeball hosts (John Crawford and Jennifer Warren)-- who've previously exchanged an odd nod and a knowing glance in which something is silently decided about how to handle this new, inquisitive element dropped in their midst — break into a broken tango to a tune on the radio.

He is NOT the same Gene we knew previously - he is full of (mostly) sound advice for Don.

February 2009: Previously EPI was suspected to be caused by autosomal recessive genes, but that is no longer thought to be the case.

Although known to have neuronal cell functions STK38L has not previously been associated with abnormal photoreceptor function; being associated with such a disease in dogs establishes this gene as a potential candidate for similar diseases in other species, including man.

This led to the eventual identification of a single nucleotide substitution in the second codon of a previously unknown gene that is now known to be the cause of PRCD in at least 18 different breeds [23].