Another interesting aspect is that the new protein is unlike
any previously known protein and appears to be present on the red blood cells of other species as well.
Not exact matches
This changes a lot of what scientists thought they
knew about how water bears deal with radiation, as they were
previously thought to have
proteins that repaired damaged DNA, rather than
proteins that halt damage altogether.
The
protein, called SP9, was
known to be important for normal medium spiny neurons, but it had not
previously been associated with Huntington's disease.
Using the same computer - based approach, the team has now been able to target the c - FLIP (cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory)
protein,
known to play a key role in cancer stem cell maintenance and survival, described in
previously published work by the Institute.
Allen
previously discovered a class of
proteins secreted by astrocytes that help neurons form active connections,
known as synapses.
In a 2006 study published in Cell, Vidal and Huda Zoghbi, a neurobiologist at Baylor College of Medicine in Houston, Texas, teamed up to show
previously unsuspected interactions among the
proteins produced by mutated genes in several of the movement disorders
known as ataxias.
Berninger and others have
previously shown that Sox2, Ascl1, and other transcription factors —
proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells»
known as glia to turn into neurons.
Interferon - inducible
protein 6 - 16 (IFI 6 - 16), a
protein not
previously known to be associated with other misfolding diseases but that was uniquely found misfolded in the urine of women with preeclampsia, is
known to help prevent cell death and, in breast cancer cells, is responsible for resistance to treatment.
Herpes virus
proteins are more «spaghetti - like» than
previously thought, which provides a vital clue in the search for an efficient treatment against a type of herpes which causes a form of cancer
known as Kaposi's sarcoma.
Cell biologists
previously didn't
know whether the LppA
protein propped up the cell wall, like pillars prop up a roof, or whether the outer membrane was tethered to the cell wall.
These include many
known DNA repair factors, as well as new
proteins of
previously unknown function.
Gao's team used a form of polymerase chain reaction analysis to scan the cells for signs of various
proteins, including some
previously found in stem cells and some
known to play a role in prostate development.
As a means to better understand such pathogen - plant interactions, Chory's team turned to the well - studied weed Arabidopsis thaliana and, in particular, an enzyme called SOBER1 — which had
previously been reported to suppress the weed's immune response to a bacterial
protein known as AvrBsT.
This succeeded, and we've identified nineteen
proteins that no one
previously knew existed in the venom,» he concludes.
Together with his team, he has discovered that the bacterial
protein EIIAGlc is not only responsible for the uptake of nutrients, which was
previously known, but also plays a central role in Salmonella colonizing the host organism.
Some of these
proteins already have been implicated in diseases such as cancer, but only a minority were
previously known to be «druggable.»
In one example, Dr. Tseng's group
previously had shown that exposing precursor white fat cells to a
protein known as BMP7 helps to spur the creation of brown fat cells.
From the resulting network predictions, the research team discovered
proteins not
previously known to be required for virulence.
It was not
previously known that cancer cells could dispose of the toxic SRC
protein this way.
We use three sources of information to update the homology - based immune catalog in Nasonia: a
previously published catalog of antimicrobial peptides [35], homology to characterized Dipteran immune
proteins based on reciprocal best blastp hits to D. melanogaster, and profile hidden Markov models (HMMs) of
known immune - related gene families derived from ImmunoDB [11](see methods for details).
SAN FRANCISCO, CA — June 27, 2017 —
Protein fragments found in semen, and
previously only
known for their ability to enhance HIV infection, also appear to play an important role in reproductive biology.
A well - studied
protein, AvrPtoB, from the bacterial pathogen Pseudomonas syringae, is
known to suppress the plant immune response, but has a
previously unknown function, according to researchers from the Boyce Thompson Institute, Cornell University and the USDA - Agricultural Research Service.
This agnostic approach has shed light on multiple
proteins and pathways not
previously known to be associated with disease.
More importantly, they also identified a few
proteins that
previously were not
known to be HCC - related, opening possibilities for candidate biomarker development.
Of these, 126 genes were orthologous to
protein - coding genes in the human genome (hereafter, human BC susceptibility genes, hBCSGs), 70 % of which are
previously reported cancer - associated genes, and ∼ 16 % are
known BC suppressor genes.
Too high a
protein intake along with persistent training had
previously kept my metabolism doing what it
knew best, burn and make glucose.