Sentences with phrase «primary breast tumors»

Patients undergoing surgical resection of primary breast tumors confront a risk for metastatic recurrence that peaks sharply 12 to 18 months after surgery.

In preclinical tests in mice, a team at CSHL was able to dramatically change the character of an aggressive, metastatic primary breast tumor by targeting a single long non-coding RNA called Malat1 with a candidate drug called an antisense oligonucleotide (ASO).

On the other hand, overexpression of miR7 significantly decreased the mammosphere - forming ability of primary breast tumor cells (Fig. 5D).

C, immunohistochemical analysis for KLF4 expression was conducted for primary breast tumors and brain metastatic tumors, and the numbers of nuclear or cytosolic staining were assessed under microscope.

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.

Carriers of the BARD1 variant, with or without the BRCA2 mutation, also had an increased risk of subsequent primary breast tumors after the first breast cancer diagnosis.

ALDH1 - positive cancer stem cells predict engraftment of primary breast tumors and are governed by a common stem cell program.

Since diet can influence insulin activation, the researchers wondered whether diet could impact breast cancer prognosis based on expression of the IGF1 receptor in the primary breast tumor tissue.

«By removing Malat1 — this one, single long non-coding RNA — we made a dramatic impact on the primary breast tumors in these mice.

By means of a non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) xenotransplant assay in combination with specific cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].

A quartet of samples were sequenced in this study — the primary breast tumor, the matched normal tissue, the brain metastasis (from which the patient died), and finally, a mouse xenograft model developed in «humanized» NODSCID mice.