IFN - γ production is one of
the primary effector functions of activated CD8 T cells in response to LCMV infection, and has been shown to be a key component of mortality in the naive mouse model of FHL2 (8).
To examine the functional role of Smad1 and Smad5 in GDF5 - induced neurite length,
primary cultures were transfected by microporation with siRNAs targeting the co-Smad4 (required for nuclear translocation of Smad1 / 5 transcriptional complex [33]-RRB- or the Smad1 and Smad5
effectors proteins, which are known targets of miR - 181a (Table 2).