She joined the Pillai lab as a post-doctoral research fellow in 2016 and continues to enjoy her work both treating patients with primary immunodeficiency in the clinic and studying the bridging gap between human
primary immunodeficiency disorders and the development of autoimmune disease pathology in the lab.
This increased incidence was driven by specific
primary immunodeficiency disorders predisposing to specific cancers, particularly lymphoma.
The USIDNET registry gathers variables including clinical, laboratory and outcome data, which together provide a health survey of the relatively small number of patients affected by
primary immunodeficiency disorders.
«This study found that patients with
primary immunodeficiency disorders have a modest increase in overall cancer incidence.
Similarly, my interest in
primary immunodeficiency disorders led me to read papers from outside my field, including papers on HIV / AIDS, which causes similar symptoms.
Additionally, men with
a primary immunodeficiency disorder were more likely to be diagnosed with skin and thyroid cancer; women with
a primary immunodeficiency disorder were more likely to be diagnosed with skin and stomach cancer.
Not exact matches
Our physicians also provide outpatient evaluation and treatment of adults with allergic and immune
disorders, particularly
primary immunodeficiency, and consults for these patients who are admitted to Stanford University Medical Center.
Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian
disorders.
• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human
immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding
disorder, dialysis, or coexisting cancer that is distinct in
primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study
Studies to improve the knowledge of genetic diseases include the natural history study for MLD, advanced diagnosis and natural history of
primary immunodeficiencies and immunedysregulatory
disorder, and immune reconstitution after hematopoietic stem cell transplantation for genetic
disorders.
For many SID
disorders treatment of the
primary condition will lead to resolution of the
immunodeficiency.
Primary immunodeficiency (PID)-- inherited immune
disorders resulting from genetic mutations, usually present at birth and diagnosed in childhood.
Abstract: Dogs with antimicrobial resistant, unresponsive, or unusual infections are due to a
primary hereditary
immunodeficiency disorder.