Unfortunately, the treatment did not improve the specific memory and thinking tests that were
the primary outcome of the study, nor did it decrease the chances of progressing to full dementia symptoms.
[5]
The primary outcome of the study was safety and tolerability, with immunological response to the vaccine as a secondary outcome.
Instruments with established construct validity and reliability were used to measure
the primary outcomes of the study.
The primary outcome of the study will be general psychopathology as measured by the Strengths and Difficulties Questionnaire.
The level of child emotional and behavioral problems was
the primary outcome of this study.
Not exact matches
«While we are disappointed CheckMate - 026 did not meet its
primary endpoint in this broad patient population, we remain committed to improving patient
outcomes through our comprehensive development program, including the ongoing Phase III CheckMate - 227
study exploring the potential
of the combination
of Opdivo plus [our other cancer immunotherapy] Yervoy for PD - L1 positive patients, and Opdivo plus Yervoy, or Opdivo plus chemotherapy in PD - L1 negative patients,» he added.
Of the 31 new studies included in this update, 21 provided data for one or more of the primary outcome
Of the 31 new
studies included in this update, 21 provided data for one or more
of the primary outcome
of the
primary outcomes.
The definition
of low risk used in the cohort
study was based on criteria contained in the NICE Intrapartum Care Guidelines.11 The
primary clinical
outcome was a composite measure
of adverse perinatal
outcomes encompassing perinatal mortality and specified neonatal morbidities (box).
We scored risk
of bias related to random sequence generation, allocation concealment, and selective reporting as unclear for the majority
of the
studies due to lack
of information.Our
primary outcome was pain.
Six models showed favourable effects on
primary outcome measures (e.g., standardized measures
of child development
outcomes and reduction in behaviour problems).13 Only
studies with
outcomes using direct observation, direct assessment, or administrative records were included.
In future updates
of this review, if appropriate, for our
primary outcomes, we will temporarily remove
studies at high or unclear risk
of bias (using the allocation concealment domain) to examine whether this has an impact on results.
Funnel plot analyses conducted for the
primary outcomes all show marked asymmetry, with each suggesting that smaller
studies showing a less beneficial effect
of the intervention may be missing.
high risk
of bias (where not all the
study's prespecified
outcomes have been reported; one or more reported
primary outcomes were not prespecified;
outcomes of interest are reported incompletely and so can not be used;
study fails to include results
of a key
outcome that would have been expected to have been reported);
«We saw significant, worse prognoses and
outcomes for women with a pregnancy - associated melanoma, compared to a control group
of non-pregnant women,» said Brian Gastman, M.D., a plastic surgeon, director
of melanoma surgery at Cleveland Clinic, and
primary investigator on the
study.
In the new
study, patients receiving angioplasty with the new stents had a 47 percent higher risk
of one
of the
outcomes identified as a
primary endpoint in the
study: death, heart attack and subsequent procedure to clear blocked arteries, as compared to patients who received bypass.
Lauren Theilen, M.D. one
of the
primary researchers
of the
study and the presenter
of the research at the upcoming SMFM annual meeting, explained, «Importantly, we are unable to say whether the hypertensive disease
of pregnancy plays a causal role here, but we feel that further
study is warranted to determine whether interventions such as early screening for chronic disease may improve long - term health
outcomes among these women.»
The
primary outcome studied was the total length
of active labor.
The
study's
primary outcomes measure was the rate
of exacerbation, defined as the number
of exacerbation events per participant year.
The effects were similar to the results
of meta - analysis
of all
studies, whether nausea and vomiting was evaluated as a
primary or secondary
outcome.
Meta - analysis
of these
primary outcome studies showed reduced rates
of nausea and vomiting for patients receiving gabapentin before surgery.
«By reducing bleeding with comparable rates
of MACCE and stent thrombosis, bivalirudin significantly improved overall 30 - day and one year
outcomes, compared with both heparin alone and heparin plus tirofiban in patients with AMI undergoing
primary PCI,» said Gregg W. Stone, MD, the
study's senior author.
The recommendations may also fail to find sufficient proof that routine screenings work because they're only looking at research done in
primary care, not
studies of outcomes from evaluations done by vision specialists, noted Dr. David Parke II, chief executive
of the American Academy
of Ophthalmology in San Francisco and author
of an editorial in JAMA Ophthalmology March 1.
In the JBJS
study, researchers reviewed the BMI, comorbidities, complications,
outcomes and cost
of care
of 8,129 patients who had undergone 6,475
primary TKRs and 1,654 revision TKRs at a major medical center between Jan. 1, 2000 and Sept. 30, 2008.
The
study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The
study also reports a predominant effect on neurodegenerative rather than inflammatory
outcomes, suggesting a novel mechanism
of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3
studies to measure the effect
of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and
primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials
of progressive disease.»
The researchers report long - term
outcomes from the Qidong Hepatitis B intervention
Study (QHBIS), a randomized controlled trial
of neonatal HBV vaccination that was conducted between 1983 and 1990 in Qidong County, a rural area in China with a high incidence
of HBV - related
primary liver cancer (PLC) and other liver diseases.
The two
primary outcomes in this
study evaluating adjunctive brivaracetam in the treatment
of partial - onset seizures in adults with epilepsy were statistically significant and clinically relevant,» said Dr. Pavel Klein, director, Mid-Atlantic Epilepsy and Sleep Center.
The duration
of mechanical ventilation, the
primary outcome for the
study, was not different between the 2 groups (intervention: median, 6.5 days vs control: median, 6.5 days).
Studies have consistently shown that providing the
primary care physician with a team - based infrastructure
of specialized, non-physician caregivers whose role is to provide a continuous framework
of monitoring and management, improves adherence to quality measures and yields superior
outcomes, cost, and patient satisfaction.
The
primary measured
outcome was carbon monoxide - confirmed self - reported 7 - day point - prevalence abstinence (the proportion
of the
study population abstinent at a specific point in time) at 26 weeks.
The
study's
primary limitation is that the sample was not large enough to detect differences in the components
of the
primary endpoint, only a composite
of these
outcomes.
The
primary outcome was safety, measured as 1) occurrence
of solicited symptoms during a 7 - day follow - up period after immunization (day
of immunization and days 1, 2, 3 and 7 after immunization); 2) occurrence
of unsolicited symptoms during a 30 - day follow - up period after each immunization (day
of immunization and 29 subsequent days); and 3) occurrence
of serious adverse events (SAE) during the
study period.
Potential cardioprotection was based on generally supportive data on lipid levels in intermediate
outcome clinical trials, trials in nonhuman primates, and a large body
of observational
studies suggesting a 40 % to 50 % reduction in risk among users
of either estrogen alone or, less frequently, combined estrogen and progestin.2 - 5 Hip fracture was designated as a secondary
outcome, supported by observational data as well as clinical trials showing benefit for bone mineral density.6, 7 Invasive breast cancer was designated as a
primary adverse
outcome based on observational data.3, 8 Additional clinical
outcomes chosen as secondary
outcomes that may plausibly be affected by hormone therapy include other cardiovascular diseases; endometrial, colorectal, and other cancers; and other fractures.3, 6,9
We also performed subgroup meta - analyses by type
of prevention (
primary v secondary: in this
study, trials involving healthy populations or patients with any specific disease except for cardiovascular disease were classified as
primary prevention trials, and trials involving patients with cardiovascular disease were classified as secondary prevention trials), type
of supplement by quality and dose (each supplement, vitamins only, antioxidants only, or antioxidants excluding vitamins), type
of outcome (cardiovascular death, angina, fatal or non-fatal myocardial infarction, stroke, or transient ischaemic attack), type
of outcome in each supplement, type
of study design (randomised, double blind, placebo controlled trial v open label, randomised controlled trial), methodological quality (high v low), duration
of treatment (< 5 years v ≥ 5 years), funding source (pharmaceutical industry v independent organisation), provider
of supplements (pharmaceutical industry v not pharmaceutical industry), type
of control (placebo v no placebo), number
of participants (≥ 10000 v < 10000), and supplements given singly or in combination with other vitamin or antioxidant supplements by quality.
While many trials have reported reliability regarding their methods as part
of the
study protocol, few investigations have made reliability the
primary outcome.
The
primary outcome of the HEALTHY
study was the combined prevalence
of overweight and obese students at the end
of the
study.
This
study evaluated a new set
of cardiac patients for the
primary outcome of diabetes, which was not significantly associated with fasting (after multiple - comparisons correction) in the first
study (37) and, thus, required additional evaluation as the
primary hypothesis test (38).
The prespecified
outcomes of the
primary study were the percentage changes in FEV1 and forced vital capacity (FVC) during the treatment period.
Australian parents decide which
primary school is best for their child based personal factors that go beyond academic
outcomes, according to new research by the Australian Institute
of Family
Studies.
Various opportunities to develop the students understanding
of using
primary and secondary sources to produce individual
outcomes and artistic
studies.
«Based on their
study, English and King recommend that in the
primary years, teachers should spend more time with the class «unpacking the
outcomes»
of the initial design (in this case the first test flight) and engage and scaffold students in discussions regarding areas for improvement before students move onto redesign,» Rosicka says.
The
primary aims
of this
study are to document the process
of moving towards new, integrated systems in each
of these cities; to highlight which strategies moved the cities forward in creating these systems and what barriers the cities encountered; to examine how these cities incorporated the needs
of students with disabilities, English language learners, and students from different economic backgrounds into their system designs; to understand how students, teachers, and parents, and others experience elements
of the new system and how these experiences differed for students with special needs; and to document quantitative
outcomes on a range
of measures, disaggregated by student subgroup.
As to the
primary question
of the
study, time spent on instructional leadership was NOT associated with student learning
outcomes.
evaluating Intellectual Development under subject headings for language arts, mathematics, social
studies and science, although the
Primary Program document also lists learning
outcomes from the personal planning and fine arts curricula under this area
of development
The Conservatives first proposed the end
of UIFSMs after the Institute
of Fiscal
Studies and the Education Endowment Foundation conducted research to show that free breakfasts for
primary pupils were more effective for learning
outcomes, and less expensive, than free lunches for pupils in their first three years
of school.
This
study analyzed the predictive relationship between reading fluency and school
outcomes across school levels (
primary, secondary, and high school), after controlling on the effect
of reading
The
primary outcome measure for the
study was the Test
of Early Mathematics Ability — Third Edition (TEMA — 3), a broad measure
of student proficiency in mathematics.
Loretta Ford and Henry Silver established the first NP training program in 1965, which then led to the emergence
of similar programs nationwide.3 While there was strong opposition to the establishment
of the profession from both nursing and physician communities, NPs were able to document increased availability
of primary care, satisfaction
of both nurses and physicians in collaborating, and equal competency and patient
outcomes when compared with physicians through a series
of published articles and
studies.
But actually, the
primary outcome variable in the
study is one that assesses quality
of reasoning — how dismissive as opposed to engaged people were w / climate evidence.
(1) Conducting quality assessment and improvement activities, including
outcomes evaluation and development
of clinical guidelines, provided that the obtaining
of generalizable knowledge is not the
primary purpose
of any
studies resulting from such activities; population - based activities relating to improving health or reducing health care costs, protocol development, case management and care coordination, contacting
of health care providers and patients with information about treatment alternatives; and related functions that do not include treatment;
Studies have shown that one
of the
primary reasons health
outcomes are not as good as they should be is because patients do not understand what the physician is telling them.