Sentences with phrase «primary outcome studied»

The primary outcome studied was the total length of active labor.

Meta - analysis of these primary outcome studies showed reduced rates of nausea and vomiting for patients receiving gabapentin before surgery.

Not exact matches

«While we are disappointed CheckMate - 026 did not meet its primary endpoint in this broad patient population, we remain committed to improving patient outcomes through our comprehensive development program, including the ongoing Phase III CheckMate - 227 study exploring the potential of the combination of Opdivo plus [our other cancer immunotherapy] Yervoy for PD - L1 positive patients, and Opdivo plus Yervoy, or Opdivo plus chemotherapy in PD - L1 negative patients,» he added.

Forty - three primary studies on infant health outcomes, 43 primary studies on maternal health outcomes, and 29 systematic reviews or meta - analyses that covered approximately 400 individual studies were included in this review.

Of the 31 new studies included in this update, 21 provided data for one or more of the primary outcomes.

Our study illustrates that a randomized intervention trial with good socioeconomic information can help assess interventions designed to improve population health not only by examining the intervention effects on primary outcomes but also by evaluating the intervention's impact on socioeconomic inequalities.

The definition of low risk used in the cohort study was based on criteria contained in the NICE Intrapartum Care Guidelines.11 The primary clinical outcome was a composite measure of adverse perinatal outcomes encompassing perinatal mortality and specified neonatal morbidities (box).

We scored risk of bias related to random sequence generation, allocation concealment, and selective reporting as unclear for the majority of the studies due to lack of information.Our primary outcome was pain.

Six models showed favourable effects on primary outcome measures (e.g., standardized measures of child development outcomes and reduction in behaviour problems).13 Only studies with outcomes using direct observation, direct assessment, or administrative records were included.

In future updates of this review, if appropriate, for our primary outcomes, we will temporarily remove studies at high or unclear risk of bias (using the allocation concealment domain) to examine whether this has an impact on results.

Primary outcomes were recorded for stopping any or exclusive breastfeeding before four to six weeks and at the last study assessment (up to six months).

Primary prevention fatherhood programs are now common in Head Start centers throughout the U.S., but few have been subjected to outcome studies.

Funnel plot analyses conducted for the primary outcomes all show marked asymmetry, with each suggesting that smaller studies showing a less beneficial effect of the intervention may be missing.

high risk of bias (where not all the study's prespecified outcomes have been reported; one or more reported primary outcomes were not prespecified; outcomes of interest are reported incompletely and so can not be used; study fails to include results of a key outcome that would have been expected to have been reported);

«We saw significant, worse prognoses and outcomes for women with a pregnancy - associated melanoma, compared to a control group of non-pregnant women,» said Brian Gastman, M.D., a plastic surgeon, director of melanoma surgery at Cleveland Clinic, and primary investigator on the study.

In the new study, patients receiving angioplasty with the new stents had a 47 percent higher risk of one of the outcomes identified as a primary endpoint in the study: death, heart attack and subsequent procedure to clear blocked arteries, as compared to patients who received bypass.

Lauren Theilen, M.D. one of the primary researchers of the study and the presenter of the research at the upcoming SMFM annual meeting, explained, «Importantly, we are unable to say whether the hypertensive disease of pregnancy plays a causal role here, but we feel that further study is warranted to determine whether interventions such as early screening for chronic disease may improve long - term health outcomes among these women.»

The study's primary outcomes measure was the rate of exacerbation, defined as the number of exacerbation events per participant year.

The effects were similar to the results of meta - analysis of all studies, whether nausea and vomiting was evaluated as a primary or secondary outcome.

«By reducing bleeding with comparable rates of MACCE and stent thrombosis, bivalirudin significantly improved overall 30 - day and one year outcomes, compared with both heparin alone and heparin plus tirofiban in patients with AMI undergoing primary PCI,» said Gregg W. Stone, MD, the study's senior author.

The recommendations may also fail to find sufficient proof that routine screenings work because they're only looking at research done in primary care, not studies of outcomes from evaluations done by vision specialists, noted Dr. David Parke II, chief executive of the American Academy of Ophthalmology in San Francisco and author of an editorial in JAMA Ophthalmology March 1.

In the JBJS study, researchers reviewed the BMI, comorbidities, complications, outcomes and cost of care of 8,129 patients who had undergone 6,475 primary TKRs and 1,654 revision TKRs at a major medical center between Jan. 1, 2000 and Sept. 30, 2008.

The researchers found that the primary measured outcome, change in peak oxygen uptake (reflects mechanisms by which iron repletion is expected to improve systemic oxygen delivery and use) from study entry to 16 weeks did not significantly differ between the two groups.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

The primary outcome measured for the study was cognitive deterioration among patients who completed assessments at study entry and 3 months.

The primary measured outcome for the study was the difference in maximum treadmill walking distance at 12 months between the groups.

The researchers report long - term outcomes from the Qidong Hepatitis B intervention Study (QHBIS), a randomized controlled trial of neonatal HBV vaccination that was conducted between 1983 and 1990 in Qidong County, a rural area in China with a high incidence of HBV - related primary liver cancer (PLC) and other liver diseases.

The two primary outcomes in this study evaluating adjunctive brivaracetam in the treatment of partial - onset seizures in adults with epilepsy were statistically significant and clinically relevant,» said Dr. Pavel Klein, director, Mid-Atlantic Epilepsy and Sleep Center.

The duration of mechanical ventilation, the primary outcome for the study, was not different between the 2 groups (intervention: median, 6.5 days vs control: median, 6.5 days).

Studies have consistently shown that providing the primary care physician with a team - based infrastructure of specialized, non-physician caregivers whose role is to provide a continuous framework of monitoring and management, improves adherence to quality measures and yields superior outcomes, cost, and patient satisfaction.

The primary measured outcome was carbon monoxide - confirmed self - reported 7 - day point - prevalence abstinence (the proportion of the study population abstinent at a specific point in time) at 26 weeks.

The study's primary limitation is that the sample was not large enough to detect differences in the components of the primary endpoint, only a composite of these outcomes.

The primary outcome was safety, measured as 1) occurrence of solicited symptoms during a 7 - day follow - up period after immunization (day of immunization and days 1, 2, 3 and 7 after immunization); 2) occurrence of unsolicited symptoms during a 30 - day follow - up period after each immunization (day of immunization and 29 subsequent days); and 3) occurrence of serious adverse events (SAE) during the study period.

Unfortunately, the treatment did not improve the specific memory and thinking tests that were the primary outcome of the study, nor did it decrease the chances of progressing to full dementia symptoms.

In one smaller prospective study looking for sex differences as primary outcome, sleep deprivation led to increased food and fat intake; however, males were more susceptible to weight gain based on greater daily caloric intake, especially during night (106).

[5] The primary outcome of the study was safety and tolerability, with immunological response to the vaccine as a secondary outcome.

Potential cardioprotection was based on generally supportive data on lipid levels in intermediate outcome clinical trials, trials in nonhuman primates, and a large body of observational studies suggesting a 40 % to 50 % reduction in risk among users of either estrogen alone or, less frequently, combined estrogen and progestin.2 - 5 Hip fracture was designated as a secondary outcome, supported by observational data as well as clinical trials showing benefit for bone mineral density.6, 7 Invasive breast cancer was designated as a primary adverse outcome based on observational data.3, 8 Additional clinical outcomes chosen as secondary outcomes that may plausibly be affected by hormone therapy include other cardiovascular diseases; endometrial, colorectal, and other cancers; and other fractures.3, 6,9

We also performed subgroup meta - analyses by type of prevention (primary v secondary: in this study, trials involving healthy populations or patients with any specific disease except for cardiovascular disease were classified as primary prevention trials, and trials involving patients with cardiovascular disease were classified as secondary prevention trials), type of supplement by quality and dose (each supplement, vitamins only, antioxidants only, or antioxidants excluding vitamins), type of outcome (cardiovascular death, angina, fatal or non-fatal myocardial infarction, stroke, or transient ischaemic attack), type of outcome in each supplement, type of study design (randomised, double blind, placebo controlled trial v open label, randomised controlled trial), methodological quality (high v low), duration of treatment (< 5 years v ≥ 5 years), funding source (pharmaceutical industry v independent organisation), provider of supplements (pharmaceutical industry v not pharmaceutical industry), type of control (placebo v no placebo), number of participants (≥ 10000 v < 10000), and supplements given singly or in combination with other vitamin or antioxidant supplements by quality.

While many trials have reported reliability regarding their methods as part of the study protocol, few investigations have made reliability the primary outcome.

The primary outcome of the HEALTHY study was the combined prevalence of overweight and obese students at the end of the study.

This study evaluated a new set of cardiac patients for the primary outcome of diabetes, which was not significantly associated with fasting (after multiple - comparisons correction) in the first study (37) and, thus, required additional evaluation as the primary hypothesis test (38).

The prespecified outcomes of the primary study were the percentage changes in FEV1 and forced vital capacity (FVC) during the treatment period.

Australian parents decide which primary school is best for their child based personal factors that go beyond academic outcomes, according to new research by the Australian Institute of Family Studies.

Various opportunities to develop the students understanding of using primary and secondary sources to produce individual outcomes and artistic studies.

«Based on their study, English and King recommend that in the primary years, teachers should spend more time with the class «unpacking the outcomes» of the initial design (in this case the first test flight) and engage and scaffold students in discussions regarding areas for improvement before students move onto redesign,» Rosicka says.

Perfect for any primary age as differentiated by outcome and matches local area study, nature or woodland topics.

The primary educational outcomes for this study were standardized math and reading scores and grade repetition.

The primary aims of this study are to document the process of moving towards new, integrated systems in each of these cities; to highlight which strategies moved the cities forward in creating these systems and what barriers the cities encountered; to examine how these cities incorporated the needs of students with disabilities, English language learners, and students from different economic backgrounds into their system designs; to understand how students, teachers, and parents, and others experience elements of the new system and how these experiences differed for students with special needs; and to document quantitative outcomes on a range of measures, disaggregated by student subgroup.

Related to the study's primary research questions, findings reflect pre-service teacher, elementary school teacher, and school - wide outcomes.

As to the primary question of the study, time spent on instructional leadership was NOT associated with student learning outcomes.