Sentences with phrase «primary tumour»

Figure 2: Ternary plots of relative sensitivities to targeted kinase inhibitors for a cohort of primary tumour samples of chronic lymphocytic leukaemia (CLL).

«Brain metastases are a secondary brain tumour, which means they are caused by cancer cells that escape from primary tumours like lung, breast or melanoma, and travel to the brain,» said Mohini Singh, the study's primary author and a PhD candidate in biochemistry at the Michael G. DeGroote School of Medicine at McMaster.

The researchers found that, in every patient, the brain metastasis and primary tumour shared some of their genetics, but there were also key differences.

In the new study, scientists at King's College London, led by Dr Anita Grigoriadis from the Breast Cancer Now Research Unit at King's College London, studied lymph node tissue and primary tumour samples from 309 breast cancer patients, who were treated between 1984 and 2002 at Guy's Hospital London.

In the second part of their work, they used primary tumour cells taken directly from 27 patients, the scientists again identified the same cytokines.

The study has been tested in metastatic patients with different primary tumours such as breast, colon and lung cancer.

In addition to primary tumours which start in the brain, the secondary or «metastatic» tumours which originate elsewhere and which migrate to the brain have been the focus of this new study.

The next step will be to test the method on patients with unknown primary tumours.

The pattern of mutations is analysed in a computer program which has been trained to find possible primary tumour localizations.

TCGA has generated vast amounts of data through the analysis of primary tumours from 33 different types of cancer, collecting 7 different data types.

The complex biology of cancer's development from primary tumour to metastases was excellently described in your story (22 June, p...

The sub analysis presented at ESMO 2017 Congress included the 826 patients in MINDACT with a primary tumour size of less than 1 cm (pT1abpN0).

Brain metastases often manifest years after the primary tumour.

This means that when we rely on analysis of a primary tumour we may miss mutations in the brain metastases that we could potentially target and treat effectively with drugs.»

Genetic characterisation of even a single brain metastasis may be superior to that of the primary tumour or a lymph node biopsy for selection of a targeted treatment.»

To date, scientists have had limited understanding of how cancers change genetically, or evolve, as they spread from the primary tumour.

«We could not detect these genetic alterations in the biopsy of the primary tumour.

In collaboration with Dr Scott Carter and Dr Gad Getz at the Broad Institute, Cambridge, USA, they analysed the genetics of biopsies taken from the primary tumour, brain metastases and normal tissues in each adult.

It is not enough to rely on the characteristics of the primary tumour because brain metastases have other specific gene alterations and in many patients this gives us better treatment alternatives.»

The genetic changes in brain metastases are independent of any occurring at the same time in the primary tumour, and in metastases elsewhere in the body, the researchers said.

In 56 % of patients, genetic alterations that potentially could be targeted with drugs were found in the brain metastasis but not in the primary tumour.

They concluded that brain metastases and the primary tumour share a common genetic ancestor.

The team examined not only the primary tumour, but also the satellite tumours — called metastases — that had spread throughout the patients» bodies.

«The disease would be defined by the molecular trigger, not the location of the primary tumour,» he says.

It could be used to prevent the return of cancer after surgical removal of the primary tumour.

Breast cancer researchers have mapped early genetic alterations in normal - looking cells at various distances from primary tumours to show how changes along the lining of mammary ducts can lead to disease.

«We therefore looked for patient characteristics that would account for this result; next generation sequencing (NGS) of the genes of interest was performed on the archival tissue samples from the patients» primary tumours,» explained Ciardiello.

Breast cancer cells that spread to other parts of the body break off and leave the primary tumour at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.

Dr Lucy Yates, first author from the Wellcome Trust Sanger Institute and Guys and St Thomas» NHS Trust, said: «As the cells that cause the spread of breast cancer leave relatively late, it means they are still quite similar to the cells in the primary tumour.

It has been controversial whether the breast cancer cells that spread to other parts of the body break off and leave the primary tumour in the breast at early or at late stages of cancer development.

We would not have seen these mutations by sequencing the primary tumour alone.

The most common cause of cancer deaths is not the primary tumour itself but metastases that subsequently form.

The method has been tested on many thousands of samples where the primary tumour was already identified, and it has proven extremely precise.

First a few cells begin to divide out of control and form a primary tumour.

The researchers then conducted experiments to have the hydrogel scaffold form at the surgical site after removal of primary tumours.

Also, the research showed that this localised delivery of combination therapy significantly inhibited the recurrence of cancer after a primary tumour was surgically removed.

So far the results suggest this approach could one day improve therapeutic benefits for patients bearing tumours or after removal of the primary tumours.

Primary tumours were surgically removed under general anaesthesia.

We are investigating how tumour cells can disseminate from the primary tumour and remain alive but clinically undetectable for many years, and how they start expanding into life threatening cancers in some patients.