In a next step the efficacy of the vaccine will be tested in a non-human
primate challenge model.
Not exact matches
To tackle the
challenge of identifying valid biomarkers the group created a multi-organ, computational
model that tracks infection dynamics in lungs, blood, and lymph nodes using the extensive non-human
primate datasets that were available.
Taken together the findings
challenge the «relationship
model» theory that, like other
primates, chimps engage in grooming on the basis of prior social interactions.
This experiment was conducted to verify the findings in the initial experiment of a hypersensitivity immunopathologic - like reaction after SARS - CoV
challenge of vaccinated animals, to determine if a higher dosage of the S protein vaccine (SV) would suppress infection and still exhibit a similar reaction, and whether the original β propiolactone inactivated whole virus vaccine (BPV) that had shown an immunopathologic - like reaction after
challenge of vaccinated ferrets and nonhuman
primates exhibited a similar immunopathologic reaction in the mouse
model [13], [14].
Weiner's team was the first to show that a DNA - based approach could impact an HIV
model challenge in nonhuman
primates.
More specifically, epigenetic programming of cells would allow them to show more pronounced inflammatory responses when exposed to
challenge (Miller et al., 2011a), an effect that has been observed in
primate models (Cole et al., 2012), as well as in humans (Irwin and Cole, 2011).