Sentences with phrase «primordial follicles»
"Primordial follicles" refers to very basic, undeveloped structures found in the ovaries of females. They are the earliest stage of follicles that have the potential to transform into mature eggs for reproduction in the future. Full definition
«Earlier menopause has been reported in women undergoing radioactive iodine treatment, and given the finite number of primordial follicles women start with at birth, radiation injury to germinal cells is not expected to be reversible,» she cautioned.
sciencedaily.com
During the last decade, some researchers have claimed that primordial follicles in adult mouse ovaries turn over and that females use adult germ - line stem cells to constantly resupply the follicle pool and sustain ovulation.
They started with primordial follicles from ovarian tissue and nourished them into a semideveloped state.
Mating; fertility; gestational indices; ovarian primordial follicle counts; estrous cyclicity; precoital interval; gestational length; offspring sex ratios; postnatal survival; nipple / areolae retention in preweanling males; epididymal sperm number, motility, and morphology; daily sperm production; and efficiency of daily sperm production were not affected at any exposure.
In adult female mice, MIS can also be a perpetual snooze button for primordial follicles, Pépin and colleagues, including Mass General and Harvard pediatric surgeon Patricia Donahoe, reported in the Feb. 28 Proceedings of the National Academy of Sciences.
The follicles that had already been growing completed their development, but after that, no new follicles were activated, leaving a collection of sleeping - beauty primordial follicles.
The outer portion of each ovary is filled with the earliest, dormant form of these egg - carrying follicles, called primordial follicles.
In mice given chemotherapy drugs, MIS - treated animals were left with more primordial follicles than untreated animals, the researchers found.
Activation of primordial follicles stopped.
In the ovary of a mouse treated with Müllerian - inhibiting substance, follicle development ceased and only primordial follicles were found (arrows, right).
Chemo can kill off the growing follicles, which means there is no more MIS to stop activation of other primordial follicles.
«A method to target the activation of primordial follicles so you could keep them for later — I think that would be beneficial.»
That ovarian tissue bears clusters of cells known as primordial follicles, which surround immature precursors to egg cells.
The active growers release MIS locally, which limits the number of primordial follicles that wake up.
Primordial follicles, the sacs that house immature eggs, reside in the outermost region of the ovary.
New experimental approaches to birth control aim to keep the primordial follicles dormant, so they can be available later in a woman's life.
But why the alarm clock goes off for one primordial follicle and not another is an open question, says reproductive biologist David Pépin of Massachusetts General Hospital and Harvard Medical School.
Their research showed that primordial follicles are highly stable, and that germ - line stem cell activity can not be detected, even in response to the death of half the existing follicles.
Around the time of birth these germ cells have formed a large reserve of primordial follicles — each containing a single immature egg.
Throughout these reproductive years of our lives, for every one dominant follicle we select, we lose, on average, 1,000 primordial follicles!
By Beth Heller, M.S. «Under such a concept unrecruited oocytes in primordial follicles, however, can not age, as current dogma holds.
At birth, the primordial follicles contain the oocyte surrounded by granulosa cells.
The process of folliculogenesis begins around 375 days before ovulation with the recruitment of primordial follicles that have been dormant since birth.