This paper was the first report to show that IRF5 is essential for TLR - mediated induction of
pro-inflammatory cytokine genes.
Not exact matches
The signal induces the expression of many innate immune and antiviral
genes and the production of antiviral
gene products,
pro-inflammatory cytokines, chemokines and interferons.
NF - κB is transcription factor that, among other functions, turns on
genes involved in inflammation and immune response, and can be activated in the presence of
pro-inflammatory cytokines.
Researchers have validated4 that, in melancholic depression, bipolar disorder, and postpartum depression, white blood cells called monocytes express
pro-inflammatory genes leading to secretion of
cytokines, while simultaneously leading to decreased cortisol sensitivity, the body's stress hormone and inflammatory buffer — a feedforward cycle.