Sentences with phrase «process in human disease»
His important discoveries have concerned the biochemical mechanisms and physiological regulation of protein breakdown in cells and the importance of this process in human disease.
https://warrenalpert.org/
«We're applying physics — and crystallography is filled with physics — to live processes in human disease.»
Not exact matches
One virus - particle doesn't change color, but as it procreates mutations in that process can make the resulting child - virus differ from the parent - virus, so that the child - virus is capable of infecting a human as well as the original host thereby opening the possibility for a new human disease.
«These new insights into the complexities of epigenetic regulation are contributing to our basic understanding of this process in human health and disease and gives us new vision for how to go about targeting errors in DNA methylation with innovative drug therapies.»
Human tissue grown in the laboratory offers a critical model for understanding the disease process.
«The discovery of HDMP in humans means that for the first time we are seeing an important mechanism in the process which causes the disease.
A joint work by EPFL, ETH Zürich and the CHUV has identified a pathological process that takes place in both mice and humans towards one of the most common diseases that people face in the industrialized world: type 2 diabetes.
The study of these highly unusual but devastating prion diseases has to date been thwarted by a lack of animal models that faithfully mimic the disease processes in humans.
Therefore, it is essential that we learn how specific types of chemical modifications normally regulate RNA function in our cells, in order to understand how dysregulation of this process contributes to human disease, says Cristian Bellodi.
And, just like in humans, a dose of antibiotics — at times used to ward off hive diseases — might disrupt the process, she warns.
The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
Focusing on antibiotics that have been used to counter infectious disease of humans, Walsh provides an up - to - date analysis of how these small molecules interfere with crucial processes in bacteria.
Further studies of processes in which GTPBP3 is involved will help towards the understanding of human diseases that are linked to mitochondrial DNA expression and to develop new therapies.
In addition, more checks and processing have to be in place due to the risk of diseases that can be transmitted from mammals to humans.&raquIn addition, more checks and processing have to be in place due to the risk of diseases that can be transmitted from mammals to humans.&raquin place due to the risk of diseases that can be transmitted from mammals to humans.»
«Single enzyme's far - reaching influence in human biology, disease: Enzyme Fam20C chemically modifies more than 100 different secreted proteins, thus directing numerous cellular processes.»
«Estrogens perform important biological functions not only in sexual development and reproduction, but also in modulating many other processes impacting health and diseases in human and animals,» Beinhauer said.
As noted in the study by Crimmins and lead author Morgan E. Levine, assistant professor at the Yale Center for Research on Aging: «A deceleration of the human aging process, whether accomplished through environment or biomedical intervention, would push the timing of aging - related disease and disability incidence closer to the end of life.»
Among them, novel genes like RHEBL1, AMHR2, PSMG1, or AGER were identified that have never before been linked to general aging processes and lifespan, but are known to directly contribute to the development of aging - associated diseases like cancer or Alzheimer's disease in humans.
«We have also tested this process in human cells taken from diseased lung tissue, and we see very similar results.»
That is when studies finally convinced scientists that the minuscule RNA snippets they had taken to calling «microRNA» were regulating cellular and genetic processes throughout the human body and were critical factors in the determination of health and disease.
An international team of researchers reached a major milestone in decoding the human genome by linking genes across all chromosome of many individual people to specific tissues and disease processes.
There are an estimated 400 - 500 kinases in the human genome, with literally dozens being activated during disease processes.
The team believes this evaporative cooling process might be used to some degree by all mushroom - producing fungi, including those that cause disease in plants, animals, and humans.
«Aberrant splicing in humans may lead to various complex diseases and also underlies the development of some forms of cancer and the onset of neurodegenerative diseases, so a better understanding of the process can add important information for our fight against these diseases.»
But researchers believe that G4 structures can inhibit certain processes in the cells, including DNA replication, and have tied them to the development of cancer and neurodegenerative diseases in humans.
Their study, carried out in rats, sheds new light on pathological processes that could underlie disease progression in humans.
Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.
«We believe it is the first example illustrating the process of a developing human heart chamber in vitro,» said Kevin Healy, a UC Berkeley professor of bioengineering, who is co-senior author of the study with Dr. Bruce Conklin, a senior investigator at the Gladstone Institute of Cardiovascular Disease and a professor of medical genetics and cellular and molecular pharmacology at UC San Francisco.
«Comparing human, chimpanzee and bonobo cells can give us clues to understand biological processes, such as infection, diseases, brain evolution, adaptation or genetic diversity,» says senior research associate Iñigo Narvaiza, who led the study with senior staff scientist Carol Marchetto at the Salk Institute in La Jolla.
In the process, the ENCODE project is reinventing the vocabulary with which biologists study, discuss and understand human inheritance and disease.
«We would also now like to broaden this research to see how much this process may play a similar role in other major human diseases.»
Through his role in the UM Center for Genome Technology, part of the Miller School of Medicine, Dr. Hedges is actively involved in the incorporation of novel genomic technologies into the process of searching for the genetic variation underlying human disease risk.
This discovery provides a significant opportunity not only to enhance our understanding of how miRNAs regulate a variety of biological processes in an important model species for studying human diseases, but can lead to further, similar research into the role that miRNAs play in animal domestication.
In a Philadelphia Inquirer op - ed, he wrote that such eternal life was in our reach because «Being able to decode the human genome allows us to develop detailed models of how major diseases, such as heart disease and cancer, progress, and gives us the tools to reprogram those processes away from disease.&raquIn a Philadelphia Inquirer op - ed, he wrote that such eternal life was in our reach because «Being able to decode the human genome allows us to develop detailed models of how major diseases, such as heart disease and cancer, progress, and gives us the tools to reprogram those processes away from disease.&raquin our reach because «Being able to decode the human genome allows us to develop detailed models of how major diseases, such as heart disease and cancer, progress, and gives us the tools to reprogram those processes away from disease.»
Mark Albers uses the olfactory system of mice and humans to help understand the early events of neurodegeneration in order to find ways to intervene early in the disease process before symptoms appear and distinguish early pathologic events from changes produced by aging.
The technique, carried out in living human cells and fruit flies, should help reveal how irregularities in protein synthesis contribute to developmental abnormalities and human disease processes including those involved in Alzheimer's disease and other memory - related disorders.
Delegates at this year's Insigneo Showcase (May 5, 2016 at The Octagon Centre in Sheffield) will hear how in silico medicine — computer simulations of the human body and its disease processes — can help improve diagnosis and prognosis for conditions like Parkinson's and pulmonary vascular disease.
Microbes have a profound effect on many human physiological processes, such as digestion and drug metabolism, and play a vital role in disease susceptibility.
«If this same alternative ubiquitination process occurs in humans, perhaps an engineered ubiquitin - editing protein could be developed to target and control processes critical to the development of many diseases, including infection,» Luo said.
Lipton went on to state, «It will be important to see if HIV / AIDS acts similarly on stem cells for other organs in the human body, as this may impact on the disease process as a whole.»
While translational research has traditionally moved basic immunology knowledge forward into clinical application, varying clinical presentations of human immune - related disease processes, as well as variability in therapeutic outcomes, have provided opportunities for discovery of novel mechanistic hypotheses directly from patients.
This mouse model for AIDS dementia mimics several features of the disease process found in humans.
«We believe it is the first example illustrating the process of a developing human heart chamber in vitro,» said Kevin Healy, PhD, a UC Berkeley professor of bioengineering, who is co-senior author of the study with Bruce Conklin, MD, a senior investigator at the Gladstone Institute of Cardiovascular Disease and a professor of medical genetics and cellular and molecular pharmacology at UC San Francisco.
«This means disease - causing bacteria in chickens are at risk of sickening humans and transferring their resistance genes in the process.
The results may indicate which genes are important for survival in the Huntington's and Parkinson's disease processes in humans.
Since they confer regulation on the majority of human genes, it is not surprising that microRNAs are involved in numerous biological processes, including cardiovascular, immunological, neurodegenerative, and psychiatric diseases and cancer.
It is based on the scientific understanding and high - throughput analyses of human immune responses to disease - related proteins in selected populations including elderly with the capability to stay healthy during the aging process.
To speed the identification of genes related to human diseases and to aid in the understanding of basic biological processes, the Howard Hughes Medical Institute (HHMI) and the Washington University...
«Although we first became aware of prions because they cause several bizarre neurological diseases, the discovery that something so awesomely similar happens in organisms as different as humans and yeast makes us suspect that there is a fundamental, common biochemical process at work here,» said study director Susan Lindquist, PhD, professor of molecular genetics and cell biology and an investigator in the Howard Hughes Medical Institute at the University of Chicago.
Loss of NEU1 also accelerated the disease process in mice bred to mimic early - onset Alzheimer's in humans.