Not exact matches
Both types of
yeasts are a single
cell fungus that breaks down the starches
in wheat flour through the
process of fermentation to create sugar that gives off carbon dioxide gas that makes the bread rise.
Yoshinori Ohsumi, the most recent prizewinner, used baker's
yeast to identify genes crucial
in autophagy, the
process by which
cells recycle their components.
The retrograde response pathway is specific to the
yeast used
in the study and supplies key amino acids to the
cell by changing the metabolic
process of the mitochondria.
Autophagy is the «self - eating»
process of consuming the portion of intracellular proteins
in the
cells of eukaryotes such as
yeast, humans and plants.
Autophagy is the «self - eating»
process of consuming unwanted elements
in the
cells of eukaryotes such as
yeast, humans and plants.
The budding
yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular
processes, with the functions of many proteins important
in the
cell cycle and signaling networks found
in human biology having first been discovered
in yeast.
To date,
yeast has taught scientists a lot about
cell division and DNA repair,
processes that go wrong
in cancer.
Aurora kinases are enzymes that control mitosis, the
process of
cell division, and were first discovered
in the 1990s
in yeast, flies and frogs.
Progeria and lamin A
processing in mammalian
cells; ubiquitin - proteasome mediated protein quality control
in yeast.
Ohsumi eventually showed that the same
processes he observed
in yeast cells occur
in human
cells.
Susan Lindquist, PhD, professor of molecular genetics and
cell biology, and colleagues showed that an improperly folded protein
in yeast cells clumps together and then corrupts other, healthy molecules of the same protein to do likewise,
in a
process much like the «seeding» of a crystal.
«Although we first became aware of prions because they cause several bizarre neurological diseases, the discovery that something so awesomely similar happens
in organisms as different as humans and
yeast makes us suspect that there is a fundamental, common biochemical
process at work here,» said study director Susan Lindquist, PhD, professor of molecular genetics and
cell biology and an investigator
in the Howard Hughes Medical Institute at the University of Chicago.
In lab cultures of human and
yeast cells, the scientists stopped the harmful clumping of FUS proteins by exposing them to phosphorylation, a
process that makes precise changes to the amino acid building blocks of proteins, increasing their negative electric charge.
By combining the fission
yeast, mouse, and human systems with the latest genomic, genetic,
cell biological, and biochemical approaches, we seek to determine how condensin and cohesin organize the functional 3D genome structures and participate
in various biological
processes, including transcriptional regulation and chromosomal dynamics, and how they contribute to oncogenic
processes.