Not exact matches
The AR - V7 variant is formed when an androgen receptor loses the end part
of the receptor, called the C - terminal end; this is deleted due to an error in RNA
processing in
tumour cells, leaving only the beginning part
of the receptor, the N - terminal end.
Tumours grow through a
process of Darwinian evolution, where cancer
cells develop an advantageous mutation that allows them to survive and multiply, producing a population
of cells which can mutate further.
The
process was so effective that 20 days later, the
cell culture showed no evidence
of any revival, suggesting that the
tumour cells had been destroyed.
According to Eckmann, «The special thing about these
processes is that they involve known molecules with very long evolutionary histories, previously receiving attention as suppressors
of tumour formation within the context
of normal
cell division.
«Shutting off vital
tumour growth
processes can lead to the death
of human brain
tumour - initiating
cells.
As well as looking for variations in the genome
of different people's
tumours, they also looked at the biological
processes at work in the
cells.
Samples
of tumours from bowel cancer patients given different doses
of resveratrol showed that even lower doses can get into cancer
cells and potentially affect
processes involved in
tumour growth.
Cell migration is highly coordinated and occurs in processes such as embryonic development, wound healing, the formation of new blood vessels, and tumour cell invas
Cell migration is highly coordinated and occurs in
processes such as embryonic development, wound healing, the formation
of new blood vessels, and
tumour cell invas
cell invasion.
Cancer
tumours manipulate a natural
cell process to promote their survival suggesting that controlling this mechanism could stop progress
of the disease, according to new research led by the University
of Oxford.
Initially, the Geneva researchers observed the vascularisation
processes of human
tumour cells from different
cell lines.
Cancer arises from the transformation
of normal
cells into
tumour cells in a multistage
process that generally progresses from a pre-cancerous lesion to a malignant
tumour.
We have identified a number
of key transcription factors that are deregulated during this
process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in
tumour cells.
Her group has developed pre-clinical models
of metastatic disease that are used to identify genes, both in the
tumour cells and in the
tumour micro-environment that regulate the
process of metastasis to specific organs such as bone, liver, lung and brain.
Understanding the
processes that restrain mutant
cells from developing into
tumours, and how they are breached when cancers do form will guide the development
of strategies to reduce the chance
of cancer development in individuals who have acquired a high level
of mutations.
Many in vivo
processes, including morphogenesis or
tumour maturation, involve small populations
of cells within a spatially restricted region.
Functional imaging using in vivo confocal microscopy which allows the analysis
of vaso - activity phenomena during hypoxia,
of ischaemia reperfusion events, or
of homing
cells in pathologic
processes, such as
tumours or inflammatory diseases.
As well as epilepsy he has developed B12 malabsoroption, two mast
cell tumours, allergic dermatitis, partial laryngeal parlaysis, and apparently is also missing the spiny
process of his sacrum.