Sentences with phrase «processing factor levels»

Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.

Not exact matches

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sfactors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sfactors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sFactors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

The U.S. federal sentencing process is a point - based system, where the nature of the offences, mitigating factors and other elements are plugged into a sort of mathematical equation to arrive at a numerical «offence level» score.

Factors that could cause actual results to differ include general business and economic conditions and the state of the solar industry; governmental support for the deployment of solar power; future available supplies of high - purity silicon; demand for end - use products by consumers and inventory levels of such products in the supply chain; changes in demand from significant customers; changes in demand from major markets such as Japan, the U.S., India and China; changes in customer order patterns; changes in product mix; capacity utilization; level of competition; pricing pressure and declines in average selling prices; delays in new product introduction; delays in utility - scale project approval process; delays in utility - scale project construction; delays in the completion of project sales; continued success in technological innovations and delivery of products with the features customers demand; shortage in supply of materials or capacity requirements; availability of financing; exchange rate fluctuations; litigation and other risks as described in the Company's SEC filings, including its annual report on Form 20 - F filed on April 27, 2017.

Factors that could cause actual results to differ include general business and economic conditions and the state of the solar industry; governmental support for the deployment of solar power; future available supplies of high - purity silicon; demand for end - use products by consumers and inventory levels of such products in the supply chain; changes in demand from significant customers; changes in demand from major markets such as Japan, the U.S., India and China; changes in customer order patterns; changes in product mix; capacity utilization; level of competition; pricing pressure and declines in average selling prices; delays in new product introduction; delays in utility - scale project approval process; delays in utility - scale project construction; continued success in technological innovations and delivery of products with the features customers demand; shortage in supply of materials or capacity requirements; availability of financing; exchange rate fluctuations; litigation and other risks as described in the Company's SEC filings, including its annual report on Form 20 - F filed on April 20, 2016.

Factors that could cause actual results to differ include general business and economic conditions and the state of the solar industry; governmental support for the deployment of solar power; future available supplies of high - purity silicon; demand for end - use products by consumers and inventory levels of such products in the supply chain; changes in demand from significant customers; changes in demand from major markets such as Japan, the U.S., India and China; changes in customer order patterns; changes in product mix; capacity utilization; level of competition; pricing pressure and declines in average selling prices; delays in new product introduction; delays in utility - scale project approval process; delays in utility - scale project construction; cancelation of utility - scale feed - in - tariff contracts in Japan; continued success in technological innovations and delivery of products with the features customers demand; shortage in supply of materials or capacity requirements; availability of financing; exchange rate fluctuations; litigation and other risks as described in the Company's SEC filings, including its annual report on Form 20 - F filed on April 27, 2017.

This process is taking into account the facilities as a huge part, current talent level, as well as some other factors.

Association of a protein biomarker with any given disease process, for example, needs to be assessed in terms of disease - independent, confounding factors that may modulate protein expression levels among different individuals.

They found that the mice can develop damage to the optic nerve despite normal pressure in the eye following KPro surgery and identified TNFa and IL - 1 as inflammatory factors involved in this process, with high levels of TNFa mediating the damage to the optic nerve.

On a molecular level this process is controlled by a wide range of factors, ensuring that the right number of undifferentiated progenitor cells differentiate into skin cells and make their way to replace the old damaged ones.

In addition, the poor quality of the standard U.S. diet — including high levels of red and processed meat and low levels of fruits and vegetables — is a major factor in a number of preventable diseases.

Erosion tends to be a long - term ongoing process due to many factors (sea level changes, subsidence, natural or human - induced sediment source modifications).

However, future island vulnerability is a complex and arguably island - specific issue and will be influenced by various interacting factors that include the rate of reef growth, the rate of sea - level rise, reef evolutionary stage and thus accommodation space, island geomorphology, and the contemporary relationship between islands and their surrounding process and sedimentary regimes (Perry et al., 2011).

Further research focused on one particular part of the process called splicing factor 1 (SFA - 1), and found that increasing the levels of this component extended the lifespan of the worms.

«In a young, healthy individual, hypoxia — low oxygen levels — triggers the body to make factors that help coordinate the growth of new blood vessels but this process doesn't work as well as we age,» says Gregg Semenza, M.D., Ph.D., professor of pediatrics and genetic medicine and director of the vascular biology program at the Johns Hopkins Institute for Cell Engineering.

These risks and uncertainties include, among others, those relating to our ability to obtain financing and to form collaborative relationships, uncertainty regarding potential future deterioration in the market for auction rate securities which could result in additional permanent impairment charges, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

LAMP2A: The A variant of lysosome - associated membrane protein 2 is a receptor involved in the cellular maintenance processes of autophagy, but levels decrease with age, and in at least some species this appears to be one of the factors involved in the age - related decline of autophagy.

These risks and uncertainties include, among others, those relating to our ability to obtain sufficient financing to continue as a going concern, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, our ability to form collaborative relationships, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

These risks and uncertainties include, among others, those relating to our ability to obtain sufficient financing to continue as a going concern, the outcome of the review of the continued listing of our common stock on The Nasdaq Stock Market, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, our ability to form collaborative relationships, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

Overlaying social factors, levels of agricultural runoff, local pollution and upwelling, a natural ocean process that brings more corrosive deep ocean water to the surface, helps tease out regional differences in vulnerability.

A new study confirms that this was not Floridians» imaginations: From 2011 to at least 2015, the rate of sea level rise across the southeastern US shot up by a factor of six, from 3 - 4 millimeters a year to 20, and a combination of oceanic and atmospheric processes seem to be responsible.

At a basic level, the physical stress of the activity triggers the release of a protein called BDNF, or brain - derived neurotrophic factor, a growth factor that supports the health of neurons and plays a role in mental processing and memory.

Since refined grains can spike insulin levels and are a highly processed carbohydrate, our increased consumption may be partially to blame for the rising rates of diabetes and obesity (though of course other factors come into play here as well).

Animal - based protein powders are highly processed, unnatural, and elevate levels of cancer - promoting hormones, methionine and insulin - like growth factor - 1 (IGF - 1) in the body.

Oxidative stress is harmful to the body at a cellular level, so much so that it is thought to be a central factor in the aging process itself.1 These suppositories contain epigallocatechin -3-gallate (EGCG), known for being one of the most potent catechins present in green tea.2

It is likely that a combination of several factors (e.g. age - related changes at the level of gene expression, infectious agents, toxic compounds, and head trauma) affects the neuronal milieu and initiates neuropathological processes leading to the formation of toxic tau and amyloid β species, reduction of synaptic plasticity, and neuronal loss resulting in development of sporadic AD.»

Soy consumption can also lead directly and indirectly to heavy metal toxicity — directly, because soy products are often processed or packaged in aluminum or processed with fluoridated water, and indirectly, because soy foods contribute to low levels of cysteine, zinc, pantothenic acid and other factors needed for detoxification.

This sets off a chain reaction of imbalance and damage at the cellular level referred to as oxidative stress - a condition thought to be a core factor in the aging process itself!

In addition, stress (both physical and mental), environment, poor foods (sugary, processed, or fast food), high blood - insulin levels (type - 2 diabetes), hormonal imbalance (estrogen and menopause) and obesity (leptin, adiponectin and other dietary hormone imbalance) are just a few of the factors that promote chronic inflammation.

The combination of the specific, irrigated grass of the Northern Great Plains, the timing of the grazing, the climate, and the extraction process are all important to ensure the maximum level of X Factor in Green Pasture Butter Oil.

After adjusting for confounding factors, hose who ate the highest levels of whole foods were the least likely to report symptoms of depression, while those who ate the highest levels of highly processed foods were most likely to report depression.

The actual effect on the body may differ, since body's own acidity level is a product of other factors and processes, such as the rate of mineral absorption, presence of other metabolites, and body's own acid / alkaline regulatory actions, based on the selective excretion or mobilization of acidic / alkaline substances.

As your HGH levels decrease, your levels of insulin - like growth factor - 1 (IGF - 1) also decrease, which is an important part of what drives your body's aging process.

The capture of the risk factor data is part of a comprehensive intake process that also involves determining how far a student is from graduation based on the number of course credits they arrive with, and every student is placed into classes based on their competency level as determined by pre-enrollment testing.

Although Berkeley's student assignment plan allows parents to rank - order their first - choice, second - choice, and third - choice schools, it considers a number of factors in the actual assignment process, including the parent's level of education, income, and primary language spoken at home.

Factors such as whether the district had appointed a district - level science teacher on «special assignment» to assist other instructors, developed professional learning communities around science, and completed most aspects of Common Core implementation were considered in the selection process.

Notwithstanding the effects of individual - level factors on postsecondary education decisions, research has found that what high schools do to help their students navigate the college - going process has significant implications on their students» postsecondary outcomes (Hill, 2008, McDonough, 1997).

The phase - in process could occur by subject, grade level, or school, and the implementation timeline will certainly be affected by a number of factors, including access to technology and funding.

Dr. McCann has more than 15 years of experience designing and implementing evaluation studies for federal, state, and local - level contracts with a general focus on examining factors that influence school improvement processes and practices.

During the process of creating an investor policy statement (IPS), factors such as required rate of return, acceptable risk levels, legal and liquidity requirements, taxes, time horizon and unique circumstances are analyzed to settle on a strategic mix of assets to include in an investor's portfolio.

The LibertyQ U.S. Large Cap Equity Index utilizes a multi-factor selection process that is designed to select equity securities from the Russell 1000 ® Index that have exposure to four investment style - factors: quality, value, momentum and low volatility — while seeking a lower level of risk and higher risk - adjusted performance than the Russell 1000 ® Index over the long term.

This process is normal at low levels but can be accelerated by several factors.

Situations that lead to insufficient enzyme levels include advanced age, strenuous exercise, illness, stress, processed food, genetic factors or antibiotic use.

Like the original game, the basic narrative is very much your typical «up - and - coming heroes stop evil and save the world in the process» framework in a simplistic sense, but how the story introduces factors such as war, religion, or child assassins into the mix elevates the narrative to a more mature level.

A lot of the techniques and a lot of the types of things that I would do to make multiplayer levels work and be successful in previous titles just don't work because of the systemic process and, frankly, what the engine is capable of — like the high dynamic range lighting and the weather factors and everything else and the sheer density of objects that you actually put into the environment in the game.

by removing the influence of exogenous factors like el Nino, volcanic eruptions, and solar variation (or at least, approximations of their influence) we can reduce the noise level in temperature time series (and reduce the level of autocorrelation in the process).

Detailed impacts, however, will vary strongly from region to region and coast to coast and therefore can not be easily generalized, as changing mean and extreme coastal water levels depend on a combination of near shore and offshore processes, related to climatic but also non-climatic anthropogenic factors, such as natural land movement arising from tectonics, volcanism or compaction; land subsidence due to anthropogenic extraction of underground resources; and changes in coastal morphology resulting from sediment transport induced by natural and / or anthropogenic factors.

My doubts on the level of improvement are based on the suspicion that the limiting factor is deeper in the data that can be collected, not so much in the methods used in processing it.

There is no intrinsic constraint on live crown area for trees of this size other than the resources the organism is able to devote to this process (except for factors like average stand height and their effect upon exposure at the individual tree level).

This finding suggests that internal community - level processes — more so than external climatic factors — are driving forest dynamics.