No one wants to
produce affected puppies, and no wants to increase the number of carriers in the breed.
This means that each parent must carry an abnormal gene and that two parents who are not affected themselves may
produce affected puppies.
However, if he were ever to be bred, his owners would want to make sure his mate wasn't also a carrier, as this could
produce affected puppies.
Researchers have identified the gene mutation that causes NEwS, and a DNA test is now available that allows breeders to avoid
producing affected puppies by never breeding two dogs to each other if they are both carriers of the abnormal gene.
If we have a dog that is a carrier for one or both disorders then we must breed to a clear dog to avoid
producing any affected puppies.
Right now, the only way to identify a carrier is if it happens to be bred to another carrier, and
produces an affected puppy.
There are several DNA tests to help guide breeders using these lines, so that they can avoid
producing affected puppies.
An eye disease called pigmentary uveitis is of emerging concern in the breed, and while it is believed to have a genetic basis, at this time there are no satisfactory tools that breeders can use to be certain to avoid
producing affected puppies.
If they ever produce an affected, we KNOW with certainty that they are a Carrier, and so is the other parent
they produced an affected puppy with.
The ideal use of DNA tests is to prevent
producing affected puppies, while at the same time maintaining genetic diversity and gradually decreasing the prevalence of the disease gene (s) in the breed.
This dog will be affected and will always pass on the defective gene,
producing all affected puppies.
Identification of the mutation (s) that cause JRD will permit development of a genetic test so that breeders can avoid
producing affected puppies, and early identification of affected dogs without clinical signs may also lead to more effective therapeutic intervention.
Not exact matches
Carrier dogs should only be mated to clear dogs so as to avoid
producing BFJE
affected puppies.
To date we have received samples from 12 dogs known to have
produced CHG
affected puppies, what we call obligate carriers, and every one has come up as a carrier on the laboratory test.
As long as a carrier is bred to a clear all the
puppies produced will either be clear or a carrier and either way none of the
puppies will ever exhibit symptoms or become
affected for these two disorders.
Therefore, we only test
puppies that we are holding on to longer as show prospects and since we have already taken the precautions in which dogs we have paired together before the breeding we will only be
producing clear or carriers and therefore none of our
puppies will ever be
affected by these disorders specifically.
Her other mates were probably not carriers, so 50 % of the
puppies were normal, 50 % were carriers, but no
affected dogs were ever
produced.
On average, 50 % of such a litter will be clear and 50 % carriers; there can be no
affected puppies produced from such a mating.
This then setup the situation where for the first time, Cyd was bred to a carrier, and
affected puppies were
produced.
Many sires, both
affected and unaffected,
produce far more offspring than the recommended limit of 105
puppies, which makes it quite difficult to measure the effect of preventive actions, and to control inherited diseases, such as distichiasis, within a population.
Breeding two carriers can
produce affected animals which cause suffering and death in young
puppies.
If a
puppy has TSCA, Toy Sheltie Club of America, registration papers, all genetic testing has been done by the breeder and the pairing has been confirmed suitable (will not
produce an «
affected»
puppy) by the TSCA.
This mode of inheritance means that one
affected dog crossed with one normal dog will
produce puppies of which half, on average, will have the disease.
Breeding Is Safe — No
Affected puppies will be
produced.
Although the disease is rare in general, within an
affected line it is important to control the gene frequency so as to prevent
producing puppies affected with the disease.
This was problematic as many
affected dogs do not actually develop signs of the disease until they are getting on in years, and have already
produced puppies.
While no breeder can guarantee that he or she will never
produce a
puppy affected with an eye disease, the frequency of these diseases could be reduced if breeders would take action, both individually and cooperatively.
Again, there is no test available to determine if a Beagle will be
affected by or carry the gene (s) for IVDD, so Beagle breeders should avoid breeding dogs who are known to have IVDD or
produce puppies affected with IVDD.
Breeding Is Safe - No
Affected puppies will be
produced.
Due to random assortment of gametes and the relatively small litter size, the actual percentage of
puppies affected with NAD
produced in Carrier to Carrier mating often deviates from the expected 25 %.
This ensures that if a potential breeding dog is a carrier of a specific disease - carrying gene that safety measures are put in place to prevent
producing puppies affected by it.
To avoid
producing NAD -
affected puppies, breeders are encouraged to test their dogs before they are bred, and to refrain from breeding two carriers to each other.
However, by using the new DNA test, breeders can test their breeding stock, and, based upon this test, breed appropriately to prevent
affected puppies from being
produced.
A carrier, if bred to another carrier, will
produce on average one
affected puppy, two carriers, and one clear
puppy for every four
puppies produced.
By using the new DNA test, breeders can test their breeding stock, and, based upon this test, breed appropriately to prevent
affected puppies from being
produced.
To avoid
producing GM1 -
affected puppies, breeders are encouraged to test their dogs before they are bred, and to refrain from breeding two carriers to each other.
While this act may intend to regulate high volume or internet sales of dogs or
puppies, the bill as currently written will
affect breeders who may co-own a number of dogs that may
produce fifty (50) or more
puppies in a year under existing USDA dog dealer regulations.
Expected average results based on at least 16
puppies: An
AFFECTED parent will aslways
produce CARRIER offspring.
Expected average results based on at least 16
puppies: CARRIER to CARRIER breedings will
produce 25 %
AFFECTED offspring, 25 % NORMAL offspring, and 50 % CARRIER offspring.
To avoid
producing SDCA1 -
affected puppies, breeders are encouraged to test their dogs before they are bred, and to refrain from breeding two carriers to each other.
The sire of this dog was one of the animals that had
produced RD
affected puppies, and was inferred as having at least one copy of mutant allele 1 based on examination of the remainder of the littermates of the carrier dog that was identified.