Sentences with phrase «produce amyloid»

These dogs also produce amyloid in organs such as the kidneys affecting their function.

There are some data that suggest the pathogens themselves can produce amyloid precursor protein (APP), which is processed into amyloid - β by the cell (2).

Those whose brains could produce amyloid - beta showed an advantage in resisting infections.

He and his colleagues showed that nerve cells engineered to produce amyloid - beta were better able than other cells to stand up to the infectious Candida albicans, a fungus.

The new strategy targets an enzyme that helps produce amyloid - β.

Not exact matches

«Because brain cells release amyloid beta during activity, we think if the brain cells can't rest the way they're supposed to and get that deep sleep, they produce a relative excess of amyloid,» Dr. Yo - El Ju of Washington University, an author of that study, told Reuters.

IN BRIEF Scientists have new evidence that suggests that THC inhibits the formation of amyloid plaques by blocking the enzyme in the brain that produces them.

The amygdala, it turns out, does not produce much alpha secretase, and even with the help of AF267B could not make enough to block the formation of beta - amyloid.

RIDE THE WAVES Compared with a mouse that received random brain stimulation (right), a mouse stimulated to produce more gamma waves (left) had less amyloid - beta (green) in its hippocampus.

That's because the boosted mice produced normal — rather than high — levels of the amyloid precursor proteins from which plaques are made.

The study, published in Nature Communications, shows that membralin regulates the cell's machinery for producing beta - amyloid (or amyloid beta, Aβ), the protein that causes neurons to die in Alzheimer's disease.

Lu and his colleagues chose to work with the bacterium E. coli because it naturally produces biofilms that contain so - called «curli fibers» — amyloid proteins that help E. coli attach to surfaces.

Next, the scientists tested their hypothesis in the widely studied worm Caenorhabditis elegans, and found that a strain genetically engineered to produce excess amyloid in their guts survived up to 3 days longer after an exposure to Salmonella and yeast than typical worms.

It not only prevented the buildup of amyloid beta (Aß), a sticky protein linked to Alzheimer's, but it also does not appear to produce the dangerous side effects of earlier versions tested in humans.

First, the researchers used mice that had been genetically modified to produce excess amounts of the human version of ß amyloid — a common Alzheimer's disease model.

«That might allow more amyloid beta to infiltrate the brain, supplementing what is produced by the brain itself and accelerating the deterioration.»

For example, antibodies targeting amyloid - β peptide (Aβ) produce inflammation in the brain in some patients.

Besides the brain, amyloid - beta is produced in blood platelets, blood vessels and muscles, and its precursor protein is found in several other organs.

UBC Psychiatry Professor Dr. Weihong Song and Neurology Professor Yan - Jiang Wang at Third Military Medical University in Chongqing attached normal mice, which don't naturally develop Alzheimer's disease, to mice modified to carry a mutant human gene that produces high levels of a protein called amyloid - beta.

People with Type 2 diabetes have an excess of a protein called islet amyloid polypeptide, or IAPP, and the accumulation of this protein is linked to the loss of insulin - producing pancreatic beta cells.

Some Alzheimer's researchers have cited evidence indicating that free - floating amyloid helps produce the corrupted p - tau via a chain of reactions that centers around GSK3 (Glycogen synthase kinase 3), an enzyme that arms tau with phosphorous, turning it into a potential biochemical assassin.

«The body produces a lot of amyloids after an injury, so in some circumstances, they may be performing a guardian function,» says study co-author and Stanford neurologist Lawrence Steinman.

b - secretase acts like a pair of molecular scissors, snipping a piece off a large protein to produce b - amyloid, a smaller protein that builds up in plaques in the brains of Alzheimer's patients and is thought to kill neurons.

That variety cropped up in a different part of the brain than the other strains, and it also produced clumps of proteins akin to the amyloid plaques found in sporadic Creutzfeldt - Jakob disease, a fatal brain disease of unknown origin that usually affects those over age 55.

The cells also produce a hormone called islet amyloid polypeptide, or IAPP.

«Our previous work showed that compared to APOE3, the apolipoprotein produced by the APOE4 gene does not bind well to amyloid - beta and so does not clear the neurotoxin from the brain.»

And more direct evidence for its role in making plaques is the fact that cells produced more beta amyloid if they contained certain mutated forms of nicastrin, the researchers report in the 7 September issue of Nature.

Amyloid is the umbrella term for protein fragments that are produced by the body and that ultimately lead to the demise of nerve cells.

All of this promoted the idea that amyloid - beta plaques weren't waste products in the brain, but rather were produced by an active immune defense system.

However, when Sup35 misfolds into its prion state, it forms amyloid fibers similar to those found in Alzheimer's patients and causes the cell's protein - producing machinery to go drastically awry.

By measuring the amount of labeled beta - amyloid by mass spectroscopy over time, the researchers were able to calculate how fast it was produced in the participants» brains and then how fast it was cleared.

If the classic approach on leeching amyloid - beta out of the brain was producing only colossal failure, they said, why not zero in on a key genetic trigger linked to a well - defined risk of developing the disease?

In addition, amyloid - β, produced by nearby neurons, may be an antimicrobial peptide that gets recruited to fight the pathogen; the peptide surrounds and seals off the pathogen (4).

They found that participants who slept very little produced more of the protein amyloid beta, which is linked to Alzheimer's.

The RTM hypothesis is that the immune systems of people who reach the ages at which AS, beta - amyloid, and other pathological aggregates begin to accumulate would generate antibodies against their abnormal form, and that people who remain free of these specific diseases might be producing antibodies that are particularly effective at keeping these aggregates at bay.

In this study, creatures that had been genetically engineered to produce high levels of amyloid beta were able to fight off infections from Salmonella and other microorganisms quickly and successfully.

One way the brain eliminates the amyloid - beta typically produced by cell activity in the brain is by moving it to the spinal fluid for disposing of.

The spiking pattern and the kind of amyloid - beta produced association could revolve around a protein known as presenilin.

Amyloid - beta was produced at the same average rate by both groups, but in the Alzheimer's group there was an average drop in the clearance rates of about 30 %.

The main constituents of extracellular amyloid plaque, amyloid β40, 42, is produced by the cleavage of amyloid precursor protein (APP).»

There are other theories as to why amyloid accumulates in the cat's pancreas, some associate it with a compound called IAPP which the pancreatic ß cells secrete in the process of producing insulin.

While amyloidosis may present itself as a symptom of another medical condition, for those suffering from amyloid disease, the cause will be due to issues within the actual bone marrow whereby abnormal antibodies are produced forming amyloid.