Priority will be given to studies that evaluate combinations of agents that induce immune deviation and / or regulation,
produce effector cell depletion or exhaustion, to achieve durable clinical remission of disease.
Not exact matches
The orbital remodeling in TED is likely induced by infiltrating T lymphocytes and mast
cells, which activate orbital fibroblast
effector cells to either proliferate and form scar -
producing cells called myofibroblasts or turn into pro-inflammatory fat
cells.
His group showed that a small number of stem -
cell like CD8 T
cells - called «memory»
cells - were enough to
produce and repeatedly replenish all of the T -
effector cells needed to fight the disease.
These include examinations of the effect of antigen structure on the spectrum of cytokines
produced after either in vivo or in vitro stimulation, as well as the ability to anergize Vα14 iNKT
cells in terms of cytokine production and
effector function by prior antigen challenge.