Stem cells, which have to divide regularly to regenerate tissues with new cells, can
produce telomerase, but not the amount required to counteract the shortening of telomeres that accumulates with ageing: over time, the tissues have fewer fresh cells and they lose their regenerative capacity.
In their research project in 2012, the researchers substantially delayed the ageing of mice by enabling their cells to
produce telomerase once again for a period of time.
Stem cells, which have to divide regularly to regenerate tissues with new cells, can
produce telomerase, but not the amount required to counteract the shortening of telomeres that accumulates with aging: over time, the tissues have fewer fresh cells and they lose their regenerative capacity.
In their research project in 2012, the researchers substantially delayed the aging of mice by enabling their cells to
produce telomerase once again for a period of time.
Not exact matches
Sometimes
telomerase is a good guy because it helps
produce immune cells and stops telomeres from shortening, but it can also make cells immortal, which prompts them to turn malignant.
The protein
produced by this gene protects the chromosome ends of the DNA from damage, and controls telomere maintenance by the
telomerase enzyme.
In the paper that is now published, they make the stem cells in the bone marrow to
produce more
telomerase, thus enabling them to repair their excessively shortened telomeres.
The second animal model attempts to reproduce hereditary aplastic anemia, which is
produced by mutations associated with the telomeres and
telomerase.
The limitation may be that normal cells do not
produce active
telomerase, which can rebuild the telomeres and keep cells from becoming senescent.
The second animal model attempts to reproduce hereditary aplastic anaemia, which is
produced by mutations associated with the telomeres and
telomerase.
From the same group studied above, Dr. Ornish measured the activity of an enzyme
produced by genes,
telomerase, believed to be involved in slowing the aging process.