Sentences with phrase «produced by mutations»

The second animal model attempts to reproduce hereditary aplastic anaemia, which is produced by mutations associated with the telomeres and telomerase.

By contrast, the neoantigen vaccine is custom - made for each patient using antigens produced by mutations unique to the patient's cancer and only present on cancer cells, thus bypassing the nature immune tolerance process.

The second animal model attempts to reproduce hereditary aplastic anemia, which is produced by mutations associated with the telomeres and telomerase.

Targeted cancer treatments are designed to attack molecules produced by mutations, but if the targeted mutation occurs on an evolutionary branch and not the trunk, the treatment will fail as other branches dominate and treatment resistant cells spread.

This epimutation is produced by a mutation in an adjacent gene.

The Liverpool - led team found that this colour change was produced by a mutation in the cortex gene, which occurred during the mid 1800s, just before the first reported sighting of black peppered moths.

Not exact matches

All evolution happens by mutations which produce changes which may be more or less advantageous to the bearer.

The other relies on mutation to produce variation that can be accepted or rejected by nature, so it takes much longer.

The notion that purely random mutation preserved in the population by natural selection would produce a gradual change, which over time would create the complexity of life we now observe (phyletic gradualism).

It was previously shown by others that a rare disease called generalized pustular psoriasis (in which the skin erupts into pustules) was caused by a genetic mutation that resulted in unrestrained activity of a protein normally produced in our skin, called IL - 36.

It has multiple hosts and can evolve by mutation but also reassortment (when two closely related strains infect the same host and exchange gene segments, producing new strains — a process distinct from mutation, when the RNA of a virus is miscoded during replication).

Using high - throughput DNA sequencing, the researchers located mutations in bacterial genes that resisted the toxicity of growth inhibitors produced by bacterial viruses.

Years after her ordeal, which she survived, scientists led by Jean - Laurent Casanova discovered that it could be explained by a rare mutation she carries that prevented her from producing a protein, interferon, that helps fight off the virus.

People with the mutation also need to be monitored by an endocrinologist, because many will suffer from a condition in which their adrenal glands fail to produce enough of a stress hormone that is needed to fight infections.

Gantz and Bier developed a method they call mutagenic chain reaction (MCR) that autocatalytically produces homozygous mutations.

«By measuring the oxygen - binding properties of these engineered hemoglobins, we discovered that the same individual mutations produced an increased oxygen - affinity in some combinations and they produced a decreased oxygen - affinity in other combinations.

The disease is caused by a genetic mutation that prevents a protein required to keep muscle cells intact from being produced.

Unless an animal can recombine the DNA they already have, they will produce an offspring with an identical set of chromosomes, in which any genetic weakness, such as disease susceptibility or physical mutation, would have no chance to be overridden by outside genetic material from a mate.

The first written record of tomatoes — from Spain in the 1500s — confirms that this mutation, which enlarges tomatoes by producing compartments known as locules, existed back in the same yellow tomatoes that gave Italians the word pomodoro, or golden apple.

Neoantigens are molecules on cell's surfaces that are produced by DNA mutations that are present in cancer cells but not in normal cells, making neoantigens ideal targets for immune therapy against cancer, say the scientists.

Here we use a stochastic, two - sex computational model implemented by computer simulation to show how male mating preference for younger females could lead to the accumulation of mutations deleterious to female fertility and thus produce a menopausal period.

Eventually, simulations produced mutation - selection balance (or alternatively, fixation) in which the introduction of new mutations was balanced by the elimination, through stochastic deaths, of existing mutations.

Mutations in a deubiquitinating enzyme of S. cerevisiae, which arose during the evolution of an aneuploid isolate, leads to improved proliferation of many aneuploid strains, likely by promoting degradation of aberrant proteins produced in perturbed stoichiometric ratios [11].

IRB Barcelona has named Joan Font - Burgada (Caldes de Montbui, Barcelona, 1977) winner of the 2018 IRB Barcelona Alumni of Excellence Award «for his important contributions to understand the development of cancer, in particular, why cancers evolve with mutations that are poorly immunogenic, and also for the identification of special hepatic reparative cells with low propensity to produce cancer,» states the report by the jury — a body formed by senior IRB Barcelona researchers with expertise across several fields of research.

Around 1:100 HIV patients, however, are protected by a mutation that prevents them from producing CCR5.

The effects of disrupting the «silent» genes revealed in these studies may be masked by the activity of related genes, or because their mutations produce defects that are not readily apparent in casual observation under normal laboratory conditions.

Programmable nucleases, ZFN, TALEN and RGENs enable gene knockout in cultured cells and organisms by producing site - specific DNA double - strand breaks, whose repair via error - prone non-homologous end joining (NHEJ) or microhomology - mediated end joining (MMEJ) gives rise to frameshift mutations.

They then identified damaging mutations in the children that would disable the protein produced by a particular gene or alter the protein's function.

«But our research showed that the Tau produced by neurons from people with the Tau mutation is different; so it is red - flagged by the cell and targeted for destruction.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Each MPN is a different condition, but they are thought to be caused by an abnormal cancer stem cell that may have acquired genetic mutations that make it unable to produce blood cells normally

LA JOLLA, CA — Researchers at the Salk Institute for Biological Studies have developed a way to use patients» own cells to potentially cure sickle cell disease and many other disorders caused by mutations in a gene that helps produce blood hemoglobin.

Interestingly, it has been reported that mice with a mutation in Kap1 were obese and had behavioral problems, and the lower expression of Kap1 that we have found in the blastocysts produced by IVC could also be related to the behavior problem reported in mice generated by IVC [43].

Over time however, mutations in these genes occur as a result of constant exposure to reactive oxygen species produced by oxidative phosphorylation, the mitochondrial energy generation process.

Although the splice - site mutation was predicted to produce a stable internally deleted protein, this was not supported by expression studies in lymphoblastoid cells.

Researchers have identified the gene mutation that causes NEwS, and a DNA test is now available that allows breeders to avoid producing affected puppies by never breeding two dogs to each other if they are both carriers of the abnormal gene.

Drugs that may be pumped out by the protein that the MDR1 is responsible for producing, but appear to be safely tolerated by dogs with the MDR1 mutation: <

In summary, Doberman pinscher breeders are now in the advantageous position of being able to begin eliminating one of the significant diseases in their breed, because of the discovery of the mutation producing vWD in this breed, and the development of a vWD DNA test by VetGen.

A genetic test has recently been developed for cerebellar ataxia, which causes a progressive decline in muscle coordination, first appearing between ages 3 and 5 years; now, by identifying dogs with the mutation, breeders can avoid producing it in their bloodlines.

A DNA test is now available and may be used by breeders to decrease frequency of the mutation in the breeding stock and to avoid producing affected progeny.

However, dog owners should know that the doses of US - produced heartworm preventive agents recommended by manufacturers and approved by the Food and Drug Administration are safe for dogs with the mutation.

He produced these pictures by cropping car advertisements, piecing together a collage of forms to create sexy yet disturbing mutations of the original automobile.