Sentences with phrase «produced dystrophin»

That was enough for the muscle to carry some weight, and one injection produced dystrophin for 3 months, the group reports in the 6 July online Nature Medicine.

Duchenne muscular dystrophy is caused by problems with the body's ability to produce dystrophin, a long protein chain that binds the interior of a muscle fiber to its surrounding support structure.

Patients suffering from Duchenne muscular dystrophy are unable to produce dystrophin.

Not exact matches

Once the UCLA researchers had produced iPS cells that were free from Duchenne mutations, they differentiated the iPS cells into cardiac muscle and skeletal muscle cells and then transplanted the skeletal muscle cells into mice that had a genetic mutation in the dystrophin gene.

Mice treated with antisense RNA (bottom) produced more dystrophin — colored red in this image — than did control mice (top).

In the current study, Dr. Rudnicki and his team discovered that muscle stem cells also express the dystrophin protein, and without this protein, they produce ten-fold fewer muscle precursor cells, which in - turn generate fewer functional muscle fibres.

Dr. Eric Olson (right) shows the dystrophin protein (red) produced in gene - edited heart muscle cells taken from a DMD patient's blood.

Children with DMD have a mutation that cripples the body's ability to produce a protein called dystrophin, which helps absorb the shock or energy that's created when a muscle contracts.

Once they were able to isolate skeletal muscle cells using the newly identified surface markers, the research team matured those cells in the lab to create dystrophin - producing muscle fibers.

Muscles from mice treated with modified human stem cells show human dystrophin - producing muscle fibers (yellow) integrated among mouse muscle fibers (red).